A randomized controlled trial of parenteral glutamine in newborns receiving total parenteral nutrition (TPN) in Hospital Universiti Sains Malaysia (HUSM)

Glutamine is a conditionally essential amino acid. Addition of glutamine in TPN of critically ill adults causes a reduction of complications such as infection. In neonates however, no clear benefits of addition of glutamine to TPN were shown in a limited number of studies, mainly performed in hig...

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Main Author:	Mohamad Ikram, Ilias
Format:	Thesis
Language:	English
Published:	2008
Subjects:	R Medicine (General)
Online Access:	http://eprints.usm.my/52258/1/CHE%20ISMAIL%20BIN%20CHE%20LAH%20-%2024%20pages.pdf
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id	my-usm-ep.52258
record_format	uketd_dc
spelling	my-usm-ep.522582022-04-11T03:54:08Z A randomized controlled trial of parenteral glutamine in newborns receiving total parenteral nutrition (TPN) in Hospital Universiti Sains Malaysia (HUSM) 2008 Mohamad Ikram, Ilias R Medicine (General) Glutamine is a conditionally essential amino acid. Addition of glutamine in TPN of critically ill adults causes a reduction of complications such as infection. In neonates however, no clear benefits of addition of glutamine to TPN were shown in a limited number of studies, mainly performed in high income countries To determine whether the addition of glutamine to standard TPN in neonates in HUSM, Malaysia improves selected neonatal outcomes This was a double blinded randomized controlled trial. Babies admitted to the NICU during the 1-year study period, requiring TPN were eligible for inclusion. Subjects were randomized either to receive glutamine added TPN (intervention) or standard TPN (control). Primary outcome measures included time taken to reach full enteral nutrition, incidence of sepsis and NEC, time taken to achieve extubation, and time to discharge from NICU Out of 270 subjects included in the study 132 were randomized to the intervention group and 138 to the control group. There were no significant differences between the two groups in terms of baseline data. The median time taken to reach full enteral nutrition was similar for both intervention and control group (6 days in each group, p= 0.52). The time taken to achieve extubation was also similar in both groups (2 days in each group, p=O. 76). The incidence of necrotising enterocolitis in the intervention group was slightly lower than for the control group but the difference was not significant (5.8% vs. 7.1% , p=O. 68). The incidence of clinical sepsis and culture proven sepsis was also not significantly different in the intervention and the control group (15.7% vs10.2%,p=0.2J and 16.5% vs 15.7%, p=0.38 respectively). Sub-group analysis for preterm and term babies for the same outcomes also showed no statistically significant differences Addition of glutamine to TPN for neonates was not shown to improve outcome. 2008 Thesis http://eprints.usm.my/52258/ http://eprints.usm.my/52258/1/CHE%20ISMAIL%20BIN%20CHE%20LAH%20-%2024%20pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	R Medicine (General)
spellingShingle	R Medicine (General) Mohamad Ikram, Ilias A randomized controlled trial of parenteral glutamine in newborns receiving total parenteral nutrition (TPN) in Hospital Universiti Sains Malaysia (HUSM)
description	Glutamine is a conditionally essential amino acid. Addition of glutamine in TPN of critically ill adults causes a reduction of complications such as infection. In neonates however, no clear benefits of addition of glutamine to TPN were shown in a limited number of studies, mainly performed in high income countries To determine whether the addition of glutamine to standard TPN in neonates in HUSM, Malaysia improves selected neonatal outcomes This was a double blinded randomized controlled trial. Babies admitted to the NICU during the 1-year study period, requiring TPN were eligible for inclusion. Subjects were randomized either to receive glutamine added TPN (intervention) or standard TPN (control). Primary outcome measures included time taken to reach full enteral nutrition, incidence of sepsis and NEC, time taken to achieve extubation, and time to discharge from NICU Out of 270 subjects included in the study 132 were randomized to the intervention group and 138 to the control group. There were no significant differences between the two groups in terms of baseline data. The median time taken to reach full enteral nutrition was similar for both intervention and control group (6 days in each group, p= 0.52). The time taken to achieve extubation was also similar in both groups (2 days in each group, p=O. 76). The incidence of necrotising enterocolitis in the intervention group was slightly lower than for the control group but the difference was not significant (5.8% vs. 7.1% , p=O. 68). The incidence of clinical sepsis and culture proven sepsis was also not significantly different in the intervention and the control group (15.7% vs10.2%,p=0.2J and 16.5% vs 15.7%, p=0.38 respectively). Sub-group analysis for preterm and term babies for the same outcomes also showed no statistically significant differences Addition of glutamine to TPN for neonates was not shown to improve outcome.
format	Thesis
qualification_level	Master's degree
author	Mohamad Ikram, Ilias
author_facet	Mohamad Ikram, Ilias
author_sort	Mohamad Ikram, Ilias
title	A randomized controlled trial of parenteral glutamine in newborns receiving total parenteral nutrition (TPN) in Hospital Universiti Sains Malaysia (HUSM)
title_short	A randomized controlled trial of parenteral glutamine in newborns receiving total parenteral nutrition (TPN) in Hospital Universiti Sains Malaysia (HUSM)
title_full	A randomized controlled trial of parenteral glutamine in newborns receiving total parenteral nutrition (TPN) in Hospital Universiti Sains Malaysia (HUSM)
title_fullStr	A randomized controlled trial of parenteral glutamine in newborns receiving total parenteral nutrition (TPN) in Hospital Universiti Sains Malaysia (HUSM)
title_full_unstemmed	A randomized controlled trial of parenteral glutamine in newborns receiving total parenteral nutrition (TPN) in Hospital Universiti Sains Malaysia (HUSM)
title_sort	randomized controlled trial of parenteral glutamine in newborns receiving total parenteral nutrition (tpn) in hospital universiti sains malaysia (husm)
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2008
url	http://eprints.usm.my/52258/1/CHE%20ISMAIL%20BIN%20CHE%20LAH%20-%2024%20pages.pdf
_version_	1747822154201694208

A randomized controlled trial of parenteral glutamine in newborns receiving total parenteral nutrition (TPN) in Hospital Universiti Sains Malaysia (HUSM)

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