Prevalence of major adversecardiovascular events (MACEs) post angioplasty-HUSM Experience

The primary objective of this study was to determine the prevalence of major adverse cardiovascular events (MACEs) in patients undergoing PCI in our cardiology unit in Hospital Universiti Sains Malaysia (HUSM). The second objective was to have a baseline demographic and angiographic data of the pa...

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Main Author:	Ng Seng, Loong
Format:	Thesis
Language:	English
Published:	2008
Subjects:	R Medicine (General)
Online Access:	http://eprints.usm.my/52312/1/DR.%20NG%20SENG%20LOONG%20-%2024%20pages.pdf
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spelling	my-usm-ep.523122022-04-13T06:52:28Z Prevalence of major adversecardiovascular events (MACEs) post angioplasty-HUSM Experience 2008 Ng Seng, Loong R Medicine (General) The primary objective of this study was to determine the prevalence of major adverse cardiovascular events (MACEs) in patients undergoing PCI in our cardiology unit in Hospital Universiti Sains Malaysia (HUSM). The second objective was to have a baseline demographic and angiographic data of the patients who had undergone PCI aswell as comparison of association between independent variables with MACEs. Risk factor control in terms of diabetic and lipid control was also analysed during clinic follow-up A total of 240 patients who underwent coronary angioplasty with stent placements were recruited into this prospective cohort study 21 patients (8.9 %) had MACEs post PCI. 5 patients had drop out from the study during follow-up. 2 variables were significantly associated with MACEs post PCI using Chi-Square test including two vessel residual disease (p<O.OO 1) and right coronary artery disease(RCA) involvement (p=0.004). Multivariate analysis maintained the association of the 2 variables including two vessel residual disease (p=0.052, adjusted OR 2.55 95% Cl 0.99-6.58) and RCA involvement (p=0.026, adjusted OR 5.53 95% CI 1.22-24.96) Multivariate analysis also identified higher HbAl C had significant association with MACEs (p=O.Oll, adjusted OR 1.93~ 95% Cl1.16-3.20) Patients who were diabetics or had high LDL-Cholesterol (LDL-C) prior to coronary angioplasty had significant improvement in metabolic risk control including reduction in HbAIC (p=0.002) and LDL-C (p<O.OOI). Furthermore, 55.7% of our hyperlipidaemic patients managed to achieve targeted LDL-C of <2.6mmol/l Conclusion: This study has shown that the prevalence of MACEs in patients undergoing PCI was not high in HUSM. Residual two vessel disease, RCA involvement and higher HbAl C were highly predictive of increased risk for MACEs post PCI. This group of patients may benefit from earlier reangiographic studies, staged revascularization therapies and more aggressive control of metabolic risk factors. 2008 Thesis http://eprints.usm.my/52312/ http://eprints.usm.my/52312/1/DR.%20NG%20SENG%20LOONG%20-%2024%20pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	R Medicine (General)
spellingShingle	R Medicine (General) Ng Seng, Loong Prevalence of major adversecardiovascular events (MACEs) post angioplasty-HUSM Experience
description	The primary objective of this study was to determine the prevalence of major adverse cardiovascular events (MACEs) in patients undergoing PCI in our cardiology unit in Hospital Universiti Sains Malaysia (HUSM). The second objective was to have a baseline demographic and angiographic data of the patients who had undergone PCI aswell as comparison of association between independent variables with MACEs. Risk factor control in terms of diabetic and lipid control was also analysed during clinic follow-up A total of 240 patients who underwent coronary angioplasty with stent placements were recruited into this prospective cohort study 21 patients (8.9 %) had MACEs post PCI. 5 patients had drop out from the study during follow-up. 2 variables were significantly associated with MACEs post PCI using Chi-Square test including two vessel residual disease (p<O.OO 1) and right coronary artery disease(RCA) involvement (p=0.004). Multivariate analysis maintained the association of the 2 variables including two vessel residual disease (p=0.052, adjusted OR 2.55 95% Cl 0.99-6.58) and RCA involvement (p=0.026, adjusted OR 5.53 95% CI 1.22-24.96) Multivariate analysis also identified higher HbAl C had significant association with MACEs (p=O.Oll, adjusted OR 1.93~ 95% Cl1.16-3.20) Patients who were diabetics or had high LDL-Cholesterol (LDL-C) prior to coronary angioplasty had significant improvement in metabolic risk control including reduction in HbAIC (p=0.002) and LDL-C (p<O.OOI). Furthermore, 55.7% of our hyperlipidaemic patients managed to achieve targeted LDL-C of <2.6mmol/l Conclusion: This study has shown that the prevalence of MACEs in patients undergoing PCI was not high in HUSM. Residual two vessel disease, RCA involvement and higher HbAl C were highly predictive of increased risk for MACEs post PCI. This group of patients may benefit from earlier reangiographic studies, staged revascularization therapies and more aggressive control of metabolic risk factors.
format	Thesis
qualification_level	Master's degree
author	Ng Seng, Loong
author_facet	Ng Seng, Loong
author_sort	Ng Seng, Loong
title	Prevalence of major adversecardiovascular events (MACEs) post angioplasty-HUSM Experience
title_short	Prevalence of major adversecardiovascular events (MACEs) post angioplasty-HUSM Experience
title_full	Prevalence of major adversecardiovascular events (MACEs) post angioplasty-HUSM Experience
title_fullStr	Prevalence of major adversecardiovascular events (MACEs) post angioplasty-HUSM Experience
title_full_unstemmed	Prevalence of major adversecardiovascular events (MACEs) post angioplasty-HUSM Experience
title_sort	prevalence of major adversecardiovascular events (maces) post angioplasty-husm experience
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2008
url	http://eprints.usm.my/52312/1/DR.%20NG%20SENG%20LOONG%20-%2024%20pages.pdf
_version_	1747822160815063040

Prevalence of major adversecardiovascular events (MACEs) post angioplasty-HUSM Experience

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