Risk of coronary heart disease in type 2 diabetes mellitus patients in Kelantan
Introduction: Type 2 diabetes mellitus (T2DM) has become a major health problem worldwide and this disease leads to a wide range of complications, including coronary heart disease (CHD). The research findings obtained are expected to help in management of T2DM patients, in order to decrease the r...
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| Format: | Thesis |
| Language: | English |
| Published: |
2011
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| Subjects: | |
| Online Access: | http://eprints.usm.my/52319/1/NURUL%20AKMAR%20BINTI%20GHANI-24%20pages.pdf |
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| Summary: | Introduction: Type 2 diabetes mellitus (T2DM) has become a major health problem
worldwide and this disease leads to a wide range of complications, including coronary
heart disease (CHD). The research findings obtained are expected to help in management
of T2DM patients, in order to decrease the risk of developing CHD, as well as other
diabetic complications.
Objectives: To determine the survival probabilities and identify the risk factors of
developing CHD among T2DM patients in Kelantan
Methods: A total of 249 T20M patients attending diabetic clinics in Kelantan who
fulfilled the inclusion criteria were included in the analysis. The study design was
retrospective record review. The patients' CHO status were determined based on
documented diagnosis by medical officer and electrocardiograph (ECG) reading. Kaplan
Meier Product Limit Estimates, Simple and Multiple Cox regressions were performed to
determine the statistically significant risk factors of developing CHO among T20M
patients in Kelantan.
Results: Overall survival probabilities of developing CHO in T20M patients in Kelantan
was 79.2% (95% CI: 69.0%, 86.4%). The 10 year survival probabilities of developing
CHO in T20M patients was 82.2 (95% CI: 84.0%, 92.8%). Significant differences of
survival probabilities of developing CHD using Log Rank test were found in
hypertension and stroke. The significant prognostic factors found in this study were stroke [Adjusted HR: 3.72 (95% CI: l.41, 9.77), P=0.008] and hypertension [Adjusted
HR: 3.84 (95% CI: 0.91, 16.15), P=0.066].
Conclusions: Overall survival rate of developing CHO in T20M patients obtained in this
study was approximately equivalent to other studies. The findings revealed that stroke
and hypertension were the prognostic factors of developing CHO among T20M patients
in Kelantan. |
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