Risk of coronary heart disease in type 2 diabetes mellitus patients in Kelantan

Introduction: Type 2 diabetes mellitus (T2DM) has become a major health problem worldwide and this disease leads to a wide range of complications, including coronary heart disease (CHD). The research findings obtained are expected to help in management of T2DM patients, in order to decrease the r...

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Main Author:	Ghani, Nurul Akmar
Format:	Thesis
Language:	English
Published:	2011
Subjects:	R Medicine
Online Access:	http://eprints.usm.my/52319/1/NURUL%20AKMAR%20BINTI%20GHANI-24%20pages.pdf
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id	my-usm-ep.52319
record_format	uketd_dc
spelling	my-usm-ep.523192022-04-14T04:08:13Z Risk of coronary heart disease in type 2 diabetes mellitus patients in Kelantan 2011 Ghani, Nurul Akmar R Medicine Introduction: Type 2 diabetes mellitus (T2DM) has become a major health problem worldwide and this disease leads to a wide range of complications, including coronary heart disease (CHD). The research findings obtained are expected to help in management of T2DM patients, in order to decrease the risk of developing CHD, as well as other diabetic complications. Objectives: To determine the survival probabilities and identify the risk factors of developing CHD among T2DM patients in Kelantan Methods: A total of 249 T20M patients attending diabetic clinics in Kelantan who fulfilled the inclusion criteria were included in the analysis. The study design was retrospective record review. The patients' CHO status were determined based on documented diagnosis by medical officer and electrocardiograph (ECG) reading. Kaplan Meier Product Limit Estimates, Simple and Multiple Cox regressions were performed to determine the statistically significant risk factors of developing CHO among T20M patients in Kelantan. Results: Overall survival probabilities of developing CHO in T20M patients in Kelantan was 79.2% (95% CI: 69.0%, 86.4%). The 10 year survival probabilities of developing CHO in T20M patients was 82.2 (95% CI: 84.0%, 92.8%). Significant differences of survival probabilities of developing CHD using Log Rank test were found in hypertension and stroke. The significant prognostic factors found in this study were stroke [Adjusted HR: 3.72 (95% CI: l.41, 9.77), P=0.008] and hypertension [Adjusted HR: 3.84 (95% CI: 0.91, 16.15), P=0.066]. Conclusions: Overall survival rate of developing CHO in T20M patients obtained in this study was approximately equivalent to other studies. The findings revealed that stroke and hypertension were the prognostic factors of developing CHO among T20M patients in Kelantan. 2011 Thesis http://eprints.usm.my/52319/ http://eprints.usm.my/52319/1/NURUL%20AKMAR%20BINTI%20GHANI-24%20pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	R Medicine
spellingShingle	R Medicine Ghani, Nurul Akmar Risk of coronary heart disease in type 2 diabetes mellitus patients in Kelantan
description	Introduction: Type 2 diabetes mellitus (T2DM) has become a major health problem worldwide and this disease leads to a wide range of complications, including coronary heart disease (CHD). The research findings obtained are expected to help in management of T2DM patients, in order to decrease the risk of developing CHD, as well as other diabetic complications. Objectives: To determine the survival probabilities and identify the risk factors of developing CHD among T2DM patients in Kelantan Methods: A total of 249 T20M patients attending diabetic clinics in Kelantan who fulfilled the inclusion criteria were included in the analysis. The study design was retrospective record review. The patients' CHO status were determined based on documented diagnosis by medical officer and electrocardiograph (ECG) reading. Kaplan Meier Product Limit Estimates, Simple and Multiple Cox regressions were performed to determine the statistically significant risk factors of developing CHO among T20M patients in Kelantan. Results: Overall survival probabilities of developing CHO in T20M patients in Kelantan was 79.2% (95% CI: 69.0%, 86.4%). The 10 year survival probabilities of developing CHO in T20M patients was 82.2 (95% CI: 84.0%, 92.8%). Significant differences of survival probabilities of developing CHD using Log Rank test were found in hypertension and stroke. The significant prognostic factors found in this study were stroke [Adjusted HR: 3.72 (95% CI: l.41, 9.77), P=0.008] and hypertension [Adjusted HR: 3.84 (95% CI: 0.91, 16.15), P=0.066]. Conclusions: Overall survival rate of developing CHO in T20M patients obtained in this study was approximately equivalent to other studies. The findings revealed that stroke and hypertension were the prognostic factors of developing CHO among T20M patients in Kelantan.
format	Thesis
qualification_level	Master's degree
author	Ghani, Nurul Akmar
author_facet	Ghani, Nurul Akmar
author_sort	Ghani, Nurul Akmar
title	Risk of coronary heart disease in type 2 diabetes mellitus patients in Kelantan
title_short	Risk of coronary heart disease in type 2 diabetes mellitus patients in Kelantan
title_full	Risk of coronary heart disease in type 2 diabetes mellitus patients in Kelantan
title_fullStr	Risk of coronary heart disease in type 2 diabetes mellitus patients in Kelantan
title_full_unstemmed	Risk of coronary heart disease in type 2 diabetes mellitus patients in Kelantan
title_sort	risk of coronary heart disease in type 2 diabetes mellitus patients in kelantan
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2011
url	http://eprints.usm.my/52319/1/NURUL%20AKMAR%20BINTI%20GHANI-24%20pages.pdf
_version_	1747822162531581952

Risk of coronary heart disease in type 2 diabetes mellitus patients in Kelantan

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