Protective Effects Of Apocynin And Catalase In Oxidative Stress Of Renal Failure, Hypertension And Hypotension Rat Models

Protective Effects Of Apocynin And Catalase In Oxidative Stress Of Renal Failure, Hypertension And Hypotension Rat Models

Oxidative stress is involved in the pathogenesis of several renal and cardiovascular diseases. In many of these diseases, there is an enhanced expression of nicotinamide adenine dinucleotide oxidase (NADPH oxidase or Nox) leading to the production of superoxide anion (O2-) and accumulation of hydrog...

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Main Author: Tan, Yong Chia
Format: Thesis
Language:English
Published: 2020
Subjects:
RS1-441 Pharmacy and materia medica
Online Access:http://eprints.usm.my/52387/1/Pages%20from%20Final%20Thesis%20Submission%20-Tan%20Yong%20Chia%20P-FD%200001-10%28R%29.pdf
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spelling my-usm-ep.523872022-04-22T02:24:22Z Protective Effects Of Apocynin And Catalase In Oxidative Stress Of Renal Failure, Hypertension And Hypotension Rat Models 2020-11 Tan, Yong Chia RS1-441 Pharmacy and materia medica Oxidative stress is involved in the pathogenesis of several renal and cardiovascular diseases. In many of these diseases, there is an enhanced expression of nicotinamide adenine dinucleotide oxidase (NADPH oxidase or Nox) leading to the production of superoxide anion (O2-) and accumulation of hydrogen peroxide (H2O2) during disease progression. This study investigated the effects of apocynin, an NADPH oxidase inhibitor, and catalase, an H2O2 scavenger, on impaired renal function and haemodynamic in cyclosporine A (CsA), L-NAME and L-arginine Wistar-Kyoto rat models. Rats received CsA (25 mg/kg/day p.o.), L-NAME (15 mg/kg/day p.o.) and L- arginine (12.5 mg/ml p.o.) respectively and were assigned to the vehicle, apocynin (2.5 mmol/L p.o.), catalase (10,000 U/kg/day i.p.) or a combination of apocynin and catalase for 14 days. Renal function and haemodynamic, and plasma oxidative stress markers were measured. In addition, histological study and molecular expression of NADPH oxidase 4 (Nox 4) mRNA were assessed at the end of the treatment period. 2020-11 Thesis http://eprints.usm.my/52387/ http://eprints.usm.my/52387/1/Pages%20from%20Final%20Thesis%20Submission%20-Tan%20Yong%20Chia%20P-FD%200001-10%28R%29.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Pusat Pengajian Sains Farmasi
institution Universiti Sains Malaysia
collection USM Institutional Repository
language English
topic RS1-441 Pharmacy and materia medica
spellingShingle RS1-441 Pharmacy and materia medica
Tan, Yong Chia
Protective Effects Of Apocynin And Catalase In Oxidative Stress Of Renal Failure, Hypertension And Hypotension Rat Models
description Oxidative stress is involved in the pathogenesis of several renal and cardiovascular diseases. In many of these diseases, there is an enhanced expression of nicotinamide adenine dinucleotide oxidase (NADPH oxidase or Nox) leading to the production of superoxide anion (O2-) and accumulation of hydrogen peroxide (H2O2) during disease progression. This study investigated the effects of apocynin, an NADPH oxidase inhibitor, and catalase, an H2O2 scavenger, on impaired renal function and haemodynamic in cyclosporine A (CsA), L-NAME and L-arginine Wistar-Kyoto rat models. Rats received CsA (25 mg/kg/day p.o.), L-NAME (15 mg/kg/day p.o.) and L- arginine (12.5 mg/ml p.o.) respectively and were assigned to the vehicle, apocynin (2.5 mmol/L p.o.), catalase (10,000 U/kg/day i.p.) or a combination of apocynin and catalase for 14 days. Renal function and haemodynamic, and plasma oxidative stress markers were measured. In addition, histological study and molecular expression of NADPH oxidase 4 (Nox 4) mRNA were assessed at the end of the treatment period.
format Thesis
qualification_name Doctor of Philosophy (PhD.)
qualification_level Doctorate
author Tan, Yong Chia
author_facet Tan, Yong Chia
author_sort Tan, Yong Chia
title Protective Effects Of Apocynin And Catalase In Oxidative Stress Of Renal Failure, Hypertension And Hypotension Rat Models
title_short Protective Effects Of Apocynin And Catalase In Oxidative Stress Of Renal Failure, Hypertension And Hypotension Rat Models
title_full Protective Effects Of Apocynin And Catalase In Oxidative Stress Of Renal Failure, Hypertension And Hypotension Rat Models
title_fullStr Protective Effects Of Apocynin And Catalase In Oxidative Stress Of Renal Failure, Hypertension And Hypotension Rat Models
title_full_unstemmed Protective Effects Of Apocynin And Catalase In Oxidative Stress Of Renal Failure, Hypertension And Hypotension Rat Models
title_sort protective effects of apocynin and catalase in oxidative stress of renal failure, hypertension and hypotension rat models
granting_institution Universiti Sains Malaysia
granting_department Pusat Pengajian Sains Farmasi
publishDate 2020
url http://eprints.usm.my/52387/1/Pages%20from%20Final%20Thesis%20Submission%20-Tan%20Yong%20Chia%20P-FD%200001-10%28R%29.pdf
_version_ 1747822173352886272

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