Synthesis And Characterisation Of N-Doped Graphene Quantum Dots/Titanium Dioxide Nanocomposite As Photosensitiser In Photodynamic Therapy For Breast Cancer Treatment

Titanium dioxide nanoparticles (TiO2 NPs) have been proven to be a potential candidate in cancer therapy, particularly in the application of photodynamic therapy (PDT). However, the application of TiO2 NPs is limited due to the fast recombination rate of electron (e-)/hole (h+) pairs attributed to t...

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Main Author:	Ramachandran, Pravena
Format:	Thesis
Language:	English
Published:	2021
Subjects:	QD1-999 Chemistry
Online Access:	http://eprints.usm.my/52488/1/PRAVENA%20AP%20RAMACHANDRAN.pdf
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id	my-usm-ep.52488
record_format	uketd_dc
spelling	my-usm-ep.524882022-05-10T07:27:07Z Synthesis And Characterisation Of N-Doped Graphene Quantum Dots/Titanium Dioxide Nanocomposite As Photosensitiser In Photodynamic Therapy For Breast Cancer Treatment 2021-03 Ramachandran, Pravena QD1-999 Chemistry Titanium dioxide nanoparticles (TiO2 NPs) have been proven to be a potential candidate in cancer therapy, particularly in the application of photodynamic therapy (PDT). However, the application of TiO2 NPs is limited due to the fast recombination rate of electron (e-)/hole (h+) pairs attributed to their wider bandgap energy. Thus, surface modification is explored to shift the absorption edge to a longer light wavelength to allow penetration into deep-seated tumours. In this study, TiO2 NPs conjugated with N-doped graphene quantum dots composites (N-GQDs/TiO2 NCs) to extend the light absorption properties of TiO2 to longer near-infrared (NIR) wavelengths. A facile one-pot hydrothermal method was employed to synthesise N-GQDs with an average particle size of 4.40 ± 1.5 nm at optimum conditions with molar ratio citric acid (CA):ethylenediamine (EDA) (1:1) at 180 °C for 4 h and primary amine (EDA) as the N-precursors. The blue emissive N-GQDs have photoluminescence (PL) quantum yield of 80.2 %, exhibited excitation-independent PL emission at 442 nm, with an excitation wavelength of 340 nm. Whereas, the anatase TiO2 NPs were synthesised using microwave-assisted synthesis in the aqueous phase with an average particle size of 11.46 ± 2.8 nm, a small crystallite size (12.2 nm) and low bandgap energy (2.93 eV). 2021-03 Thesis http://eprints.usm.my/52488/ http://eprints.usm.my/52488/1/PRAVENA%20AP%20RAMACHANDRAN.pdf application/pdf en public masters Perpustakaan Hamzah Sendut Pusat Pengajian Sains Kimia
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	QD1-999 Chemistry
spellingShingle	QD1-999 Chemistry Ramachandran, Pravena Synthesis And Characterisation Of N-Doped Graphene Quantum Dots/Titanium Dioxide Nanocomposite As Photosensitiser In Photodynamic Therapy For Breast Cancer Treatment
description	Titanium dioxide nanoparticles (TiO2 NPs) have been proven to be a potential candidate in cancer therapy, particularly in the application of photodynamic therapy (PDT). However, the application of TiO2 NPs is limited due to the fast recombination rate of electron (e-)/hole (h+) pairs attributed to their wider bandgap energy. Thus, surface modification is explored to shift the absorption edge to a longer light wavelength to allow penetration into deep-seated tumours. In this study, TiO2 NPs conjugated with N-doped graphene quantum dots composites (N-GQDs/TiO2 NCs) to extend the light absorption properties of TiO2 to longer near-infrared (NIR) wavelengths. A facile one-pot hydrothermal method was employed to synthesise N-GQDs with an average particle size of 4.40 ± 1.5 nm at optimum conditions with molar ratio citric acid (CA):ethylenediamine (EDA) (1:1) at 180 °C for 4 h and primary amine (EDA) as the N-precursors. The blue emissive N-GQDs have photoluminescence (PL) quantum yield of 80.2 %, exhibited excitation-independent PL emission at 442 nm, with an excitation wavelength of 340 nm. Whereas, the anatase TiO2 NPs were synthesised using microwave-assisted synthesis in the aqueous phase with an average particle size of 11.46 ± 2.8 nm, a small crystallite size (12.2 nm) and low bandgap energy (2.93 eV).
format	Thesis
qualification_level	Master's degree
author	Ramachandran, Pravena
author_facet	Ramachandran, Pravena
author_sort	Ramachandran, Pravena
title	Synthesis And Characterisation Of N-Doped Graphene Quantum Dots/Titanium Dioxide Nanocomposite As Photosensitiser In Photodynamic Therapy For Breast Cancer Treatment
title_short	Synthesis And Characterisation Of N-Doped Graphene Quantum Dots/Titanium Dioxide Nanocomposite As Photosensitiser In Photodynamic Therapy For Breast Cancer Treatment
title_full	Synthesis And Characterisation Of N-Doped Graphene Quantum Dots/Titanium Dioxide Nanocomposite As Photosensitiser In Photodynamic Therapy For Breast Cancer Treatment
title_fullStr	Synthesis And Characterisation Of N-Doped Graphene Quantum Dots/Titanium Dioxide Nanocomposite As Photosensitiser In Photodynamic Therapy For Breast Cancer Treatment
title_full_unstemmed	Synthesis And Characterisation Of N-Doped Graphene Quantum Dots/Titanium Dioxide Nanocomposite As Photosensitiser In Photodynamic Therapy For Breast Cancer Treatment
title_sort	synthesis and characterisation of n-doped graphene quantum dots/titanium dioxide nanocomposite as photosensitiser in photodynamic therapy for breast cancer treatment
granting_institution	Perpustakaan Hamzah Sendut
granting_department	Pusat Pengajian Sains Kimia
publishDate	2021
url	http://eprints.usm.my/52488/1/PRAVENA%20AP%20RAMACHANDRAN.pdf
_version_	1747822186864836608

Synthesis And Characterisation Of N-Doped Graphene Quantum Dots/Titanium Dioxide Nanocomposite As Photosensitiser In Photodynamic Therapy For Breast Cancer Treatment

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