Diagnostic accuracy of cytology smear and frozen section in glioma
Introduction: Glioma is the commonest primary malignant brain tumour and diagnosis is based on cytology smear, frozen section and histopathological examination. Intraoperative pathological diagnosis using either cytology smear, frozen section or combination of both, plays a crucial role in patient’s...
Saved in:
| Main Author: | |
|---|---|
| Format: | Thesis |
| Language: | English |
| Published: |
2020
|
| Subjects: | |
| Online Access: | http://eprints.usm.my/52574/1/Sarah%20Zulkarnain-24%20pages.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| id |
my-usm-ep.52574 |
|---|---|
| record_format |
uketd_dc |
| spelling |
my-usm-ep.525742022-05-24T04:27:10Z Diagnostic accuracy of cytology smear and frozen section in glioma 2020 Zulkarnain, Sarah R Medicine Introduction: Glioma is the commonest primary malignant brain tumour and diagnosis is based on cytology smear, frozen section and histopathological examination. Intraoperative pathological diagnosis using either cytology smear, frozen section or combination of both, plays a crucial role in patient’s future management and prognosis. This study aims to determine the accuracy of cytology smear and frozen section in glioma, and to compare the difference between both techniques. Methods: A cross-sectional study was conducted involving 22 cases of glioma diagnosed intraoperatively from January 2013 until August 2019 in Hospital Universiti Sains Malaysia. The selected tissues were processed for cytology smear and frozen section. The remaining tissues were proceeded for paraffin section. The diagnosis was categorized as either low-grade or high-grade glioma based on cellularity, nuclear pleomorphism, mitotic count, microvascular proliferation and necrosis. The sensitivity and specificity of the frozen section and cytology smears were determined based on paraffin section being as the gold standard. The accuracy of both techniques was compared using statistical analysis. Results: The overall sensitivity and specificity of cytology smear were 100% and 76.9%, respectively. Meanwhile, the sensitivity and specificity of frozen section were 100% and 84.6%. There was no significant difference in diagnostic accuracy between cytology smear and frozen section in glioma (p>0.05). Results: The overall sensitivity and specificity of cytology smear were 100% and 76.9%, respectively. Meanwhile, the sensitivity and specificity of frozen section were 100% and 84.6%. There was no significant difference in diagnostic accuracy between cytology smear and frozen section in glioma (p>0.05). 2020 Thesis http://eprints.usm.my/52574/ http://eprints.usm.my/52574/1/Sarah%20Zulkarnain-24%20pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan |
| institution |
Universiti Sains Malaysia |
| collection |
USM Institutional Repository |
| language |
English |
| topic |
R Medicine |
| spellingShingle |
R Medicine Zulkarnain, Sarah Diagnostic accuracy of cytology smear and frozen section in glioma |
| description |
Introduction: Glioma is the commonest primary malignant brain tumour and diagnosis is based on cytology smear, frozen section and histopathological examination. Intraoperative pathological diagnosis using either cytology smear, frozen section or combination of both, plays a crucial role in patient’s future management and prognosis. This study aims to determine the accuracy of cytology smear and frozen section in glioma, and to compare the difference between both techniques.
Methods: A cross-sectional study was conducted involving 22 cases of glioma diagnosed intraoperatively from January 2013 until August 2019 in Hospital Universiti Sains Malaysia. The selected tissues were processed for cytology smear and frozen section. The remaining tissues were proceeded for paraffin section. The diagnosis was categorized as either low-grade or high-grade glioma based on cellularity, nuclear pleomorphism, mitotic count, microvascular proliferation and necrosis. The sensitivity and specificity of the frozen section and cytology smears were determined based on paraffin section being as the gold standard. The accuracy of both techniques was compared using statistical analysis.
Results: The overall sensitivity and specificity of cytology smear were 100% and 76.9%, respectively. Meanwhile, the sensitivity and specificity of frozen section were 100% and 84.6%. There was no significant difference in diagnostic accuracy between cytology smear and frozen section in glioma (p>0.05).
Results: The overall sensitivity and specificity of cytology smear were 100% and 76.9%, respectively. Meanwhile, the sensitivity and specificity of frozen section were 100% and 84.6%. There was no significant difference in diagnostic accuracy between cytology smear and frozen section in glioma (p>0.05). |
| format |
Thesis |
| qualification_level |
Master's degree |
| author |
Zulkarnain, Sarah |
| author_facet |
Zulkarnain, Sarah |
| author_sort |
Zulkarnain, Sarah |
| title |
Diagnostic accuracy of cytology smear and frozen section in glioma |
| title_short |
Diagnostic accuracy of cytology smear and frozen section in glioma |
| title_full |
Diagnostic accuracy of cytology smear and frozen section in glioma |
| title_fullStr |
Diagnostic accuracy of cytology smear and frozen section in glioma |
| title_full_unstemmed |
Diagnostic accuracy of cytology smear and frozen section in glioma |
| title_sort |
diagnostic accuracy of cytology smear and frozen section in glioma |
| granting_institution |
Universiti Sains Malaysia |
| granting_department |
Pusat Pengajian Sains Perubatan |
| publishDate |
2020 |
| url |
http://eprints.usm.my/52574/1/Sarah%20Zulkarnain-24%20pages.pdf |
| _version_ |
1747822193467719680 |