Pharmacokinetic And Pharmacodynamic Modeling Of Mitragynine In PainTolerance

Mitragyna speciosa, also known as ‘Ketum’or ‘Biak-biak’ in Malaysia and Kratom in Thailand, is a native plant to Southeast Asia. It has a long history of folk medicine use in Southeast Asia and recently has gained popularity in Western countries. Mitragynine (MG) is the principal alkaloid found in t...

全面介紹

Saved in:
書目詳細資料
主要作者: Ramachandram, Dinesh Sangarran
格式: Thesis
語言:English
出版: 2020
主題:
在線閱讀:http://eprints.usm.my/52605/1/Pages%20from%20DINESH%20SANGARRAN%20AL%20RAMACHANDRAM%20-%20TESIS.pdf
標簽: 添加標簽
沒有標簽, 成為第一個標記此記錄!
id my-usm-ep.52605
record_format uketd_dc
spelling my-usm-ep.526052022-05-26T07:11:37Z Pharmacokinetic And Pharmacodynamic Modeling Of Mitragynine In PainTolerance 2020-11 Ramachandram, Dinesh Sangarran RM300-666 Drugs and their actions Mitragyna speciosa, also known as ‘Ketum’or ‘Biak-biak’ in Malaysia and Kratom in Thailand, is a native plant to Southeast Asia. It has a long history of folk medicine use in Southeast Asia and recently has gained popularity in Western countries. Mitragynine (MG) is the principal alkaloid found in the leaves of Mitragyna speciosa and has been reported to be responsible for the plant’s therapeutic actions. Pain relief is among many self-reported beneficial kratom effects. However, there have not been any controlled clinical studies reported on the analgesic property of Ketum employed a standardized formulation. The objective of this study is to evaluate the PKPD of mitragynine in human subjects. In view of this, work was undertaken in Universiti Sains Malaysia to scientifically assess the pain relief effects of Ketum decoction in a randomized, double-blind, placebo- controlled study. Ketum and placebo decoctions were prepared and standardized as a formulation to be administered to the subjects in the clinical study. 2020-11 Thesis http://eprints.usm.my/52605/ http://eprints.usm.my/52605/1/Pages%20from%20DINESH%20SANGARRAN%20AL%20RAMACHANDRAM%20-%20TESIS.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Penyelidikan Dadah Dan Ubat-Ubatan
institution Universiti Sains Malaysia
collection USM Institutional Repository
language English
topic RM300-666 Drugs and their actions
spellingShingle RM300-666 Drugs and their actions
Ramachandram, Dinesh Sangarran
Pharmacokinetic And Pharmacodynamic Modeling Of Mitragynine In PainTolerance
description Mitragyna speciosa, also known as ‘Ketum’or ‘Biak-biak’ in Malaysia and Kratom in Thailand, is a native plant to Southeast Asia. It has a long history of folk medicine use in Southeast Asia and recently has gained popularity in Western countries. Mitragynine (MG) is the principal alkaloid found in the leaves of Mitragyna speciosa and has been reported to be responsible for the plant’s therapeutic actions. Pain relief is among many self-reported beneficial kratom effects. However, there have not been any controlled clinical studies reported on the analgesic property of Ketum employed a standardized formulation. The objective of this study is to evaluate the PKPD of mitragynine in human subjects. In view of this, work was undertaken in Universiti Sains Malaysia to scientifically assess the pain relief effects of Ketum decoction in a randomized, double-blind, placebo- controlled study. Ketum and placebo decoctions were prepared and standardized as a formulation to be administered to the subjects in the clinical study.
format Thesis
qualification_level Master's degree
author Ramachandram, Dinesh Sangarran
author_facet Ramachandram, Dinesh Sangarran
author_sort Ramachandram, Dinesh Sangarran
title Pharmacokinetic And Pharmacodynamic Modeling Of Mitragynine In PainTolerance
title_short Pharmacokinetic And Pharmacodynamic Modeling Of Mitragynine In PainTolerance
title_full Pharmacokinetic And Pharmacodynamic Modeling Of Mitragynine In PainTolerance
title_fullStr Pharmacokinetic And Pharmacodynamic Modeling Of Mitragynine In PainTolerance
title_full_unstemmed Pharmacokinetic And Pharmacodynamic Modeling Of Mitragynine In PainTolerance
title_sort pharmacokinetic and pharmacodynamic modeling of mitragynine in paintolerance
granting_institution Universiti Sains Malaysia
granting_department Pusat Penyelidikan Dadah Dan Ubat-Ubatan
publishDate 2020
url http://eprints.usm.my/52605/1/Pages%20from%20DINESH%20SANGARRAN%20AL%20RAMACHANDRAM%20-%20TESIS.pdf
_version_ 1747822198853206016