Impact Of Traditional Prognostic Factor And Chemotherapy Schedule Modification On Breast Cancer Patients: A 5 Year Retrospective Study In A District Specialist Hospital In The State Of Perak

Chemotherapy schedule modifications are done in clinical practice due to treatment complications or the patients preference. Multiple clinical studies have established the negative prognostic impact of dose delay on survival rates. This study aims to investigate the prevalence and reason for chemoth...

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Main Author:	Gunasekaran, Gobi Hariyanayagam
Format:	Thesis
Language:	English
Published:	2021
Subjects:	RS1-441 Pharmacy and materia medica
Online Access:	http://eprints.usm.my/52695/1/GOBI%20HARIYANAYAGAM%20AL%20GUNASEKARAN%20-%20TESIS24.pdf
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id	my-usm-ep.52695
record_format	uketd_dc
spelling	my-usm-ep.526952022-05-31T17:57:53Z Impact Of Traditional Prognostic Factor And Chemotherapy Schedule Modification On Breast Cancer Patients: A 5 Year Retrospective Study In A District Specialist Hospital In The State Of Perak 2021-10 Gunasekaran, Gobi Hariyanayagam RS1-441 Pharmacy and materia medica Chemotherapy schedule modifications are done in clinical practice due to treatment complications or the patients preference. Multiple clinical studies have established the negative prognostic impact of dose delay on survival rates. This study aims to investigate the prevalence and reason for chemotherapy schedule modification with the impact of schedule modification on the Overall Survival (OS) of the breast cancer patient. This retrospective cohort study was done among breast cancer patients receiving chemotherapy from 2013 to 2017 and was followed until 31 Dec 2018. Medical records of patients with cancer were reviewed. Inclusion criteria involved the female patients over eighteen years old, primary carcinoma of the breast, received Anthracycline or Taxane based chemotherapy regimen and completed more than two cycles of chemotherapy. Patients were categorised into three categories of no schedule modification, with schedule modification, and incomplete schedule. The Kaplan-Meier were used to test for survival differences in the univariate setting, and the Cox regression model was used in the multivariate setting. This study aims to measure the prevalence, OS rates, and Hazard Risk (HR) of these three treatment categories. Among 171 patients receiving chemotherapy, 28 (16.4%) had no schedule modification, 118 (69.0%) had schedule modification, and the remaining 25 (14.6%) had an incomplete schedule with OS of 75.0%, 59.3%, and 52.0%, respectively 2021-10 Thesis http://eprints.usm.my/52695/ http://eprints.usm.my/52695/1/GOBI%20HARIYANAYAGAM%20AL%20GUNASEKARAN%20-%20TESIS24.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Farmasi
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RS1-441 Pharmacy and materia medica
spellingShingle	RS1-441 Pharmacy and materia medica Gunasekaran, Gobi Hariyanayagam Impact Of Traditional Prognostic Factor And Chemotherapy Schedule Modification On Breast Cancer Patients: A 5 Year Retrospective Study In A District Specialist Hospital In The State Of Perak
description	Chemotherapy schedule modifications are done in clinical practice due to treatment complications or the patients preference. Multiple clinical studies have established the negative prognostic impact of dose delay on survival rates. This study aims to investigate the prevalence and reason for chemotherapy schedule modification with the impact of schedule modification on the Overall Survival (OS) of the breast cancer patient. This retrospective cohort study was done among breast cancer patients receiving chemotherapy from 2013 to 2017 and was followed until 31 Dec 2018. Medical records of patients with cancer were reviewed. Inclusion criteria involved the female patients over eighteen years old, primary carcinoma of the breast, received Anthracycline or Taxane based chemotherapy regimen and completed more than two cycles of chemotherapy. Patients were categorised into three categories of no schedule modification, with schedule modification, and incomplete schedule. The Kaplan-Meier were used to test for survival differences in the univariate setting, and the Cox regression model was used in the multivariate setting. This study aims to measure the prevalence, OS rates, and Hazard Risk (HR) of these three treatment categories. Among 171 patients receiving chemotherapy, 28 (16.4%) had no schedule modification, 118 (69.0%) had schedule modification, and the remaining 25 (14.6%) had an incomplete schedule with OS of 75.0%, 59.3%, and 52.0%, respectively
format	Thesis
qualification_level	Master's degree
author	Gunasekaran, Gobi Hariyanayagam
author_facet	Gunasekaran, Gobi Hariyanayagam
author_sort	Gunasekaran, Gobi Hariyanayagam
title	Impact Of Traditional Prognostic Factor And Chemotherapy Schedule Modification On Breast Cancer Patients: A 5 Year Retrospective Study In A District Specialist Hospital In The State Of Perak
title_short	Impact Of Traditional Prognostic Factor And Chemotherapy Schedule Modification On Breast Cancer Patients: A 5 Year Retrospective Study In A District Specialist Hospital In The State Of Perak
title_full	Impact Of Traditional Prognostic Factor And Chemotherapy Schedule Modification On Breast Cancer Patients: A 5 Year Retrospective Study In A District Specialist Hospital In The State Of Perak
title_fullStr	Impact Of Traditional Prognostic Factor And Chemotherapy Schedule Modification On Breast Cancer Patients: A 5 Year Retrospective Study In A District Specialist Hospital In The State Of Perak
title_full_unstemmed	Impact Of Traditional Prognostic Factor And Chemotherapy Schedule Modification On Breast Cancer Patients: A 5 Year Retrospective Study In A District Specialist Hospital In The State Of Perak
title_sort	impact of traditional prognostic factor and chemotherapy schedule modification on breast cancer patients: a 5 year retrospective study in a district specialist hospital in the state of perak
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Farmasi
publishDate	2021
url	http://eprints.usm.my/52695/1/GOBI%20HARIYANAYAGAM%20AL%20GUNASEKARAN%20-%20TESIS24.pdf
_version_	1747822205460283392

Impact Of Traditional Prognostic Factor And Chemotherapy Schedule Modification On Breast Cancer Patients: A 5 Year Retrospective Study In A District Specialist Hospital In The State Of Perak

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