$Single Agent And Synergistic Activity Of Latex C-Serum With Led Red Light In Cancer Cell Lines$

Single Agent And Synergistic Activity Of Latex C-Serum With Led Red Light In Cancer Cell Lines

Hevea brasiliensis rubber latex dialysed C-serum supernatant (DCS) sub-fraction has been reported to possess potential anti-proliferation activities against specific human breast (MDA-MB-231) and liver (HepG2) cancer cell lines through autoschizis cell death pathway. Further investigations on DCS tr...

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Bibliographic Details
Main Author:	Yang, Kok Lee
Format:	Thesis
Language:	English
Published:	2021
Subjects:	QH1 Natural history (General - Including nature conservation geographical distribution)
Online Access:	http://eprints.usm.my/53332/1/YANG%20KOK%20LEE%20-%20TESIS.pdf%20cut.pdf
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id	my-usm-ep.53332
record_format	uketd_dc
spelling	my-usm-ep.533322022-07-13T02:04:26Z Single Agent And Synergistic Activity Of Latex C-Serum With Led Red Light In Cancer Cell Lines 2021-01 Yang, Kok Lee QH1 Natural history (General - Including nature conservation, geographical distribution) Hevea brasiliensis rubber latex dialysed C-serum supernatant (DCS) sub-fraction has been reported to possess potential anti-proliferation activities against specific human breast (MDA-MB-231) and liver (HepG2) cancer cell lines through autoschizis cell death pathway. Further investigations on DCS treatment (concentrations ranged between 0 to 100 μg/mL) on anti-proliferative effect in this study have shown that IC50 of DCS was at 8.81 μg/mL and 22.12 μg/mL for DBTRG (human brain glioblastoma) and MKN74 (human gastric tubular adenocarcinoma), respectively. Although DCS showed specificity in cancer cell lines based on cell viability assays, its genotoxicity effects are important in view of its employment in human subjects if it would be developed into an anti-cancer drug. 2021-01 Thesis http://eprints.usm.my/53332/ http://eprints.usm.my/53332/1/YANG%20KOK%20LEE%20-%20TESIS.pdf%20cut.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Pusat Pengajian Sains Kajihayat (School of Biological Science)
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	QH1 Natural history (General - Including nature conservation geographical distribution)
spellingShingle	QH1 Natural history (General - Including nature conservation geographical distribution) Yang, Kok Lee Single Agent And Synergistic Activity Of Latex C-Serum With Led Red Light In Cancer Cell Lines
description	Hevea brasiliensis rubber latex dialysed C-serum supernatant (DCS) sub-fraction has been reported to possess potential anti-proliferation activities against specific human breast (MDA-MB-231) and liver (HepG2) cancer cell lines through autoschizis cell death pathway. Further investigations on DCS treatment (concentrations ranged between 0 to 100 μg/mL) on anti-proliferative effect in this study have shown that IC50 of DCS was at 8.81 μg/mL and 22.12 μg/mL for DBTRG (human brain glioblastoma) and MKN74 (human gastric tubular adenocarcinoma), respectively. Although DCS showed specificity in cancer cell lines based on cell viability assays, its genotoxicity effects are important in view of its employment in human subjects if it would be developed into an anti-cancer drug.
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Yang, Kok Lee
author_facet	Yang, Kok Lee
author_sort	Yang, Kok Lee
title	Single Agent And Synergistic Activity Of Latex C-Serum With Led Red Light In Cancer Cell Lines
title_short	Single Agent And Synergistic Activity Of Latex C-Serum With Led Red Light In Cancer Cell Lines
title_full	Single Agent And Synergistic Activity Of Latex C-Serum With Led Red Light In Cancer Cell Lines
title_fullStr	Single Agent And Synergistic Activity Of Latex C-Serum With Led Red Light In Cancer Cell Lines
title_full_unstemmed	Single Agent And Synergistic Activity Of Latex C-Serum With Led Red Light In Cancer Cell Lines
title_sort	single agent and synergistic activity of latex c-serum with led red light in cancer cell lines
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Kajihayat (School of Biological Science)
publishDate	2021
url	http://eprints.usm.my/53332/1/YANG%20KOK%20LEE%20-%20TESIS.pdf%20cut.pdf
_version_	1747822235635154944

Single Agent And Synergistic Activity Of Latex C-Serum With Led Red Light In Cancer Cell Lines

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