Neuroprotective Effects Of Xanthone-Enriched Fraction Garcinia Mangostana And Alpha-Mangostin In Chronic Cerebral Hypoperfusion Rats
In this study, the protective effect of xanthone enriched fraction of G. mangostana (XEFGM) and α-MG were evaluated in an animal model of VaD induced by chronic cerebral hypoperfusion also known as- two vessel occlusion (2VO). In the first part of this study, XEFGM (25, 50, and 100 mg/kg) and α-MG (...
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2021
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my-usm-ep.533332022-07-13T07:29:18Z Neuroprotective Effects Of Xanthone-Enriched Fraction Garcinia Mangostana And Alpha-Mangostin In Chronic Cerebral Hypoperfusion Rats 2021-02 Tiang, Ning RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry In this study, the protective effect of xanthone enriched fraction of G. mangostana (XEFGM) and α-MG were evaluated in an animal model of VaD induced by chronic cerebral hypoperfusion also known as- two vessel occlusion (2VO). In the first part of this study, XEFGM (25, 50, and 100 mg/kg) and α-MG (25 and 50 mg/kg) were administrated to 2VO rats and the rats were then subjected to behavioral test for learning and reference memory evaluation. The result suggested that, 50 mg/kg of α-MG treated 2VO significantly improved spatial learning and reference memory in Morris water maze test. 2021-02 Thesis http://eprints.usm.my/53333/ http://eprints.usm.my/53333/1/TIANG%20NING%20-%20TESIS.pdf%20cut.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Penyelidikan Dadah dan Ubat-ubatan (Centre for Drug Research) |
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Universiti Sains Malaysia |
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USM Institutional Repository |
| language |
English |
| topic |
RC0321 Neuroscience Biological psychiatry Neuropsychiatry |
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RC0321 Neuroscience Biological psychiatry Neuropsychiatry Tiang, Ning Neuroprotective Effects Of Xanthone-Enriched Fraction Garcinia Mangostana And Alpha-Mangostin In Chronic Cerebral Hypoperfusion Rats |
| description |
In this study, the protective effect of xanthone enriched fraction of G. mangostana (XEFGM) and α-MG were evaluated in an animal model of VaD induced by chronic cerebral hypoperfusion also known as- two vessel occlusion (2VO). In the first part of this study, XEFGM (25, 50, and 100 mg/kg) and α-MG (25 and 50 mg/kg) were administrated to 2VO rats and the rats were then subjected to behavioral test for learning and reference memory evaluation. The result suggested that, 50 mg/kg of α-MG treated 2VO significantly improved spatial learning and reference memory in Morris water maze test. |
| format |
Thesis |
| qualification_level |
Master's degree |
| author |
Tiang, Ning |
| author_facet |
Tiang, Ning |
| author_sort |
Tiang, Ning |
| title |
Neuroprotective Effects Of Xanthone-Enriched Fraction Garcinia Mangostana And Alpha-Mangostin In Chronic Cerebral Hypoperfusion Rats |
| title_short |
Neuroprotective Effects Of Xanthone-Enriched Fraction Garcinia Mangostana And Alpha-Mangostin In Chronic Cerebral Hypoperfusion Rats |
| title_full |
Neuroprotective Effects Of Xanthone-Enriched Fraction Garcinia Mangostana And Alpha-Mangostin In Chronic Cerebral Hypoperfusion Rats |
| title_fullStr |
Neuroprotective Effects Of Xanthone-Enriched Fraction Garcinia Mangostana And Alpha-Mangostin In Chronic Cerebral Hypoperfusion Rats |
| title_full_unstemmed |
Neuroprotective Effects Of Xanthone-Enriched Fraction Garcinia Mangostana And Alpha-Mangostin In Chronic Cerebral Hypoperfusion Rats |
| title_sort |
neuroprotective effects of xanthone-enriched fraction garcinia mangostana and alpha-mangostin in chronic cerebral hypoperfusion rats |
| granting_institution |
Universiti Sains Malaysia |
| granting_department |
Pusat Penyelidikan Dadah dan Ubat-ubatan (Centre for Drug Research) |
| publishDate |
2021 |
| url |
http://eprints.usm.my/53333/1/TIANG%20NING%20-%20TESIS.pdf%20cut.pdf |
| _version_ |
1747822235880521728 |