Hormone receptor status of breast cancers and other prognostic factors in two study centres

In Malaysia, breast cancer is the commonest cancer in all ethnic. Breast cancer in Malaysian women occurs in the younger age group compared with Western countries and the fourth most common cause of death among all cancers in Malaysia. Stage at presentation here is more advanced with tumor size b...

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Main Author:	Hassan, Mohammad Syauki
Format:	Thesis
Language:	English
Published:	2010
Subjects:	RG Gynecology and obstetrics
Online Access:	http://eprints.usm.my/53574/1/DR%20MOHAMMAD%20SYAUKI%20HASSAN-24%20pages.pdf
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id	my-usm-ep.53574
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spelling	my-usm-ep.535742022-07-25T07:28:49Z Hormone receptor status of breast cancers and other prognostic factors in two study centres 2010 Hassan, Mohammad Syauki RG Gynecology and obstetrics In Malaysia, breast cancer is the commonest cancer in all ethnic. Breast cancer in Malaysian women occurs in the younger age group compared with Western countries and the fourth most common cause of death among all cancers in Malaysia. Stage at presentation here is more advanced with tumor size being much larger and with either locally advanced or metastatic breast cancer. There was a higher proportion of hormone receptor-negative with higher grade tumour in Asian patients compared to Western countries raises questions whether a different pattern of breast cancer is seen in Asian. OBJECTIVES The aim of this study is to evaluate the age at presentation and hormone receptor status of breast cancers and its association with other established prognostic factors for example tumor size, lymph node status and tumour grade. METHODOLOGY This is a study of retrospective record review of 160 patients diagnosed from 1st January 2003 to 31st December 2008. List of name of patients have been obtained from cancer registry of Pathology Department in Hospital University Sains of Malaysia (HUSM) and Hospital Raja Perempuan Zainab II (HRPZ II). The data were obtained from medical records. Data were entered into data collection protocol and were analyzed using SPSS software version 12.0. RESULTS This study identifies the association between tumour size and lymph node involvement and staging of breast cancer at presentation. Majority breast cancer patients in this study were from 40 to 49 years old. Minority of patients had tumour size 2cm and below at presentation. The commonest stage at presentation of breast cancer was at stage II and grade III. Only 47.8% were ER (+)and 51.5% were PR (+)respectively. CONCLUSION This study cannot prove of association between young age and receptor status with advanced stage of breast cancer. Majority of patients presented with large size tumour with poorly differentiated histology, estrogen receptor-negative and lymph node metastases. 2010 Thesis http://eprints.usm.my/53574/ http://eprints.usm.my/53574/1/DR%20MOHAMMAD%20SYAUKI%20HASSAN-24%20pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RG Gynecology and obstetrics
spellingShingle	RG Gynecology and obstetrics Hassan, Mohammad Syauki Hormone receptor status of breast cancers and other prognostic factors in two study centres
description	In Malaysia, breast cancer is the commonest cancer in all ethnic. Breast cancer in Malaysian women occurs in the younger age group compared with Western countries and the fourth most common cause of death among all cancers in Malaysia. Stage at presentation here is more advanced with tumor size being much larger and with either locally advanced or metastatic breast cancer. There was a higher proportion of hormone receptor-negative with higher grade tumour in Asian patients compared to Western countries raises questions whether a different pattern of breast cancer is seen in Asian. OBJECTIVES The aim of this study is to evaluate the age at presentation and hormone receptor status of breast cancers and its association with other established prognostic factors for example tumor size, lymph node status and tumour grade. METHODOLOGY This is a study of retrospective record review of 160 patients diagnosed from 1st January 2003 to 31st December 2008. List of name of patients have been obtained from cancer registry of Pathology Department in Hospital University Sains of Malaysia (HUSM) and Hospital Raja Perempuan Zainab II (HRPZ II). The data were obtained from medical records. Data were entered into data collection protocol and were analyzed using SPSS software version 12.0. RESULTS This study identifies the association between tumour size and lymph node involvement and staging of breast cancer at presentation. Majority breast cancer patients in this study were from 40 to 49 years old. Minority of patients had tumour size 2cm and below at presentation. The commonest stage at presentation of breast cancer was at stage II and grade III. Only 47.8% were ER (+)and 51.5% were PR (+)respectively. CONCLUSION This study cannot prove of association between young age and receptor status with advanced stage of breast cancer. Majority of patients presented with large size tumour with poorly differentiated histology, estrogen receptor-negative and lymph node metastases.
format	Thesis
qualification_level	Master's degree
author	Hassan, Mohammad Syauki
author_facet	Hassan, Mohammad Syauki
author_sort	Hassan, Mohammad Syauki
title	Hormone receptor status of breast cancers and other prognostic factors in two study centres
title_short	Hormone receptor status of breast cancers and other prognostic factors in two study centres
title_full	Hormone receptor status of breast cancers and other prognostic factors in two study centres
title_fullStr	Hormone receptor status of breast cancers and other prognostic factors in two study centres
title_full_unstemmed	Hormone receptor status of breast cancers and other prognostic factors in two study centres
title_sort	hormone receptor status of breast cancers and other prognostic factors in two study centres
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2010
url	http://eprints.usm.my/53574/1/DR%20MOHAMMAD%20SYAUKI%20HASSAN-24%20pages.pdf
_version_	1747822250565828608

Hormone receptor status of breast cancers and other prognostic factors in two study centres

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