Post operative morbidity and 3 years survival rate in diabetic and non diabetic patients undergoing coronary artery bypass grafting in Hospital Universiti Sains Malaysia

Diabetes mellitus is a risk factor for development of coronary artery disease and also being linked to worse outcomes after coronary artery bypass grafting (CABG). The purpose of the study is to evaluate the post operative morbidity and survival rate at 3 years following CABG in patients with dia...

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Main Author:	Ikhwan Sani, Mohamad
Format:	Thesis
Language:	English
Published:	2009
Subjects:	R Medicine (General)
Online Access:	http://eprints.usm.my/53950/1/DR%20IKHWAN%20SANI%20BIN%20MOHAMAD%2024%20pages.pdf
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spelling	my-usm-ep.539502022-08-10T03:06:26Z Post operative morbidity and 3 years survival rate in diabetic and non diabetic patients undergoing coronary artery bypass grafting in Hospital Universiti Sains Malaysia 2009 Ikhwan Sani, Mohamad R Medicine (General) Diabetes mellitus is a risk factor for development of coronary artery disease and also being linked to worse outcomes after coronary artery bypass grafting (CABG). The purpose of the study is to evaluate the post operative morbidity and survival rate at 3 years following CABG in patients with diabetes mellitus compared to non diabetics. This study was done on 205 patients who underwent elective isolated CABG in Cardiothoracic Uni4 Hospital Universiti Sains Malaysi~ Kubang Kerian from January 2002 to December 2005. Our study group were divided into diabetes and non diabetes. 90 patients (43.9%) were diabetics and 115 (56.1%) were non diabetics. There were 169 (82.4%) male patients and 36 (17.6%) female patients. Patients' age ranged from 39 to 77 years old. The data showed that diabetic patients had poorer ejection fraction (59% vs 62%, p= 0.03) and preoperative renal failure (25.6% vs 16.6%, p=0.02). There were no significant difference in term of other comorbidities between diabetes and non diabetes group , which were hypertension, chronic obstructive airway disease (COAD), smoking status, cerebrovascular accident (CV A), and hyperlipidaemia (HPL). Intraoperative findings showed no significant findings between both groups which include cardiopulmonary bypass (CPB) time, amount of cardioplegia, aortic cross clamped time and number of bypass performed. Post operative outcome revealed that diabetic patients had higher risk of developing harvested site infection (61.1% vs 23.5%, p<O.OOI) and post operative renal failure (27.7% vs 7.8%, p<O.OO I). However, no significant differences were noted in other post operative complications, which were sternal wound infection, pneumonia, post operative bleeding, arrythmias and CV A. During follow up until 3 years post operatively, we found that diabetic patients were more frequently being readmitted due to cardiac causes (42.2% vs 27.8%, p=0.03). No differences in term of reoperation rate and recurrent angina post CABO. OveraJI mortality until 3 years post CABO was 15 patients where 10 patients died within 30 days. We reported that no significant outcome between both groups in term of 30 days mortality and 3 years survival rate. As conclusion, this study supported the evidence that diabetes mellitus were the significant prognostic factors for some post CABO complications especiaJiy harvested site infection and post operative renal failure. However, it is difficult to really determine either the disease contribute to post operative death or not in view of smaJJ overall number of mortality . 2009 Thesis http://eprints.usm.my/53950/ http://eprints.usm.my/53950/1/DR%20IKHWAN%20SANI%20BIN%20MOHAMAD%2024%20pages.pdf application/pdf en public masters Pusat Pengajian Sains Perubatan PPSP, Universiti Sains Malaysia
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	R Medicine (General)
spellingShingle	R Medicine (General) Ikhwan Sani, Mohamad Post operative morbidity and 3 years survival rate in diabetic and non diabetic patients undergoing coronary artery bypass grafting in Hospital Universiti Sains Malaysia
description	Diabetes mellitus is a risk factor for development of coronary artery disease and also being linked to worse outcomes after coronary artery bypass grafting (CABG). The purpose of the study is to evaluate the post operative morbidity and survival rate at 3 years following CABG in patients with diabetes mellitus compared to non diabetics. This study was done on 205 patients who underwent elective isolated CABG in Cardiothoracic Uni4 Hospital Universiti Sains Malaysi~ Kubang Kerian from January 2002 to December 2005. Our study group were divided into diabetes and non diabetes. 90 patients (43.9%) were diabetics and 115 (56.1%) were non diabetics. There were 169 (82.4%) male patients and 36 (17.6%) female patients. Patients' age ranged from 39 to 77 years old. The data showed that diabetic patients had poorer ejection fraction (59% vs 62%, p= 0.03) and preoperative renal failure (25.6% vs 16.6%, p=0.02). There were no significant difference in term of other comorbidities between diabetes and non diabetes group , which were hypertension, chronic obstructive airway disease (COAD), smoking status, cerebrovascular accident (CV A), and hyperlipidaemia (HPL). Intraoperative findings showed no significant findings between both groups which include cardiopulmonary bypass (CPB) time, amount of cardioplegia, aortic cross clamped time and number of bypass performed. Post operative outcome revealed that diabetic patients had higher risk of developing harvested site infection (61.1% vs 23.5%, p<O.OOI) and post operative renal failure (27.7% vs 7.8%, p<O.OO I). However, no significant differences were noted in other post operative complications, which were sternal wound infection, pneumonia, post operative bleeding, arrythmias and CV A. During follow up until 3 years post operatively, we found that diabetic patients were more frequently being readmitted due to cardiac causes (42.2% vs 27.8%, p=0.03). No differences in term of reoperation rate and recurrent angina post CABO. OveraJI mortality until 3 years post CABO was 15 patients where 10 patients died within 30 days. We reported that no significant outcome between both groups in term of 30 days mortality and 3 years survival rate. As conclusion, this study supported the evidence that diabetes mellitus were the significant prognostic factors for some post CABO complications especiaJiy harvested site infection and post operative renal failure. However, it is difficult to really determine either the disease contribute to post operative death or not in view of smaJJ overall number of mortality .
format	Thesis
qualification_level	Master's degree
author	Ikhwan Sani, Mohamad
author_facet	Ikhwan Sani, Mohamad
author_sort	Ikhwan Sani, Mohamad
title	Post operative morbidity and 3 years survival rate in diabetic and non diabetic patients undergoing coronary artery bypass grafting in Hospital Universiti Sains Malaysia
title_short	Post operative morbidity and 3 years survival rate in diabetic and non diabetic patients undergoing coronary artery bypass grafting in Hospital Universiti Sains Malaysia
title_full	Post operative morbidity and 3 years survival rate in diabetic and non diabetic patients undergoing coronary artery bypass grafting in Hospital Universiti Sains Malaysia
title_fullStr	Post operative morbidity and 3 years survival rate in diabetic and non diabetic patients undergoing coronary artery bypass grafting in Hospital Universiti Sains Malaysia
title_full_unstemmed	Post operative morbidity and 3 years survival rate in diabetic and non diabetic patients undergoing coronary artery bypass grafting in Hospital Universiti Sains Malaysia
title_sort	post operative morbidity and 3 years survival rate in diabetic and non diabetic patients undergoing coronary artery bypass grafting in hospital universiti sains malaysia
granting_institution	Pusat Pengajian Sains Perubatan
granting_department	PPSP, Universiti Sains Malaysia
publishDate	2009
url	http://eprints.usm.my/53950/1/DR%20IKHWAN%20SANI%20BIN%20MOHAMAD%2024%20pages.pdf
_version_	1747822265718800384

Post operative morbidity and 3 years survival rate in diabetic and non diabetic patients undergoing coronary artery bypass grafting in Hospital Universiti Sains Malaysia

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