Formulation Of Solid Self-Emulsifying Drug Delivery System Using Mixedtocotrienols As The Model Drug
The present study was conducted to develop and evaluate the formulation of a solid self-emulsifying system for enhancing the oral bioavailability of a poorly water-soluble liquid active compound, namely tocotrienols. A suitable solid carrier with high liquid holding capacity was selected. Various...
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my-usm-ep.539662022-08-10T07:14:03Z Formulation Of Solid Self-Emulsifying Drug Delivery System Using Mixedtocotrienols As The Model Drug 2020-04 Lee, You Zhuan RS1-441 Pharmacy and materia medica The present study was conducted to develop and evaluate the formulation of a solid self-emulsifying system for enhancing the oral bioavailability of a poorly water-soluble liquid active compound, namely tocotrienols. A suitable solid carrier with high liquid holding capacity was selected. Various properties of several solid self-emulsifying formulations including emulsification efficiency, emulsion droplet size, desorption and powder flow properties were investigated. A solid selfemulsifying formulation with the desired properties was successfully developed, using magnesium aluminosilicate (Neusilin US2) as the solid carrier, containing 65 to 70% TRF and 30 to 35% surfactants (poloxamer and Labrasol) with sodium lauryl sulphate as wetting agent. The formulation showed good self-emulsification efficiency with stable emulsion formed, demonstrated excellent powder flowability, complete desorption of tocotrienols from carrier, and small emulsion droplet size of 210 to 303 nm. Subsequent in vivo studies using Sprague-Dawley rats showed that the formulation with a combination of surfactants (poloxamer and Labrasol) had a faster rate of absorption compared to using only single surfactant (either poloxamer or Labrasol). In a following in vivo study, the solid self-emulsifying preparation with combined surfactants (D4) showed enhanced oral bioavailability (3.4 to 3.8 times higher) compared to the non self-emulsifying oily liquid preparation when administered at fasted state in rats. The formulation which was in a dry powder form was further developed into a hard gelatin capsule dosage form, containing 100 mg tocotrienols in each capsule. 2020-04 Thesis http://eprints.usm.my/53966/ http://eprints.usm.my/53966/1/LEE%20YOU%20ZHUAN.pdf application/pdf en public phd doctoral Perpustakaan Hamzah Sendut Pusat Pengajian Sains Farmasi |
| institution |
Universiti Sains Malaysia |
| collection |
USM Institutional Repository |
| language |
English |
| topic |
RS1-441 Pharmacy and materia medica |
| spellingShingle |
RS1-441 Pharmacy and materia medica Lee, You Zhuan Formulation Of Solid Self-Emulsifying Drug Delivery System Using Mixedtocotrienols As The Model Drug |
| description |
The present study was conducted to develop and evaluate the formulation of a
solid self-emulsifying system for enhancing the oral bioavailability of a poorly
water-soluble liquid active compound, namely tocotrienols. A suitable solid carrier
with high liquid holding capacity was selected. Various properties of several solid
self-emulsifying formulations including emulsification efficiency, emulsion droplet
size, desorption and powder flow properties were investigated. A solid selfemulsifying
formulation with the desired properties was successfully developed,
using magnesium aluminosilicate (Neusilin US2) as the solid carrier, containing 65
to 70% TRF and 30 to 35% surfactants (poloxamer and Labrasol) with sodium lauryl
sulphate as wetting agent. The formulation showed good self-emulsification
efficiency with stable emulsion formed, demonstrated excellent powder flowability,
complete desorption of tocotrienols from carrier, and small emulsion droplet size of
210 to 303 nm. Subsequent in vivo studies using Sprague-Dawley rats showed that
the formulation with a combination of surfactants (poloxamer and Labrasol) had a
faster rate of absorption compared to using only single surfactant (either poloxamer
or Labrasol). In a following in vivo study, the solid self-emulsifying preparation with
combined surfactants (D4) showed enhanced oral bioavailability (3.4 to 3.8 times
higher) compared to the non self-emulsifying oily liquid preparation when
administered at fasted state in rats. The formulation which was in a dry powder form
was further developed into a hard gelatin capsule dosage form, containing 100 mg
tocotrienols in each capsule. |
| format |
Thesis |
| qualification_name |
Doctor of Philosophy (PhD.) |
| qualification_level |
Doctorate |
| author |
Lee, You Zhuan |
| author_facet |
Lee, You Zhuan |
| author_sort |
Lee, You Zhuan |
| title |
Formulation Of Solid Self-Emulsifying
Drug Delivery System Using Mixedtocotrienols
As The Model Drug |
| title_short |
Formulation Of Solid Self-Emulsifying
Drug Delivery System Using Mixedtocotrienols
As The Model Drug |
| title_full |
Formulation Of Solid Self-Emulsifying
Drug Delivery System Using Mixedtocotrienols
As The Model Drug |
| title_fullStr |
Formulation Of Solid Self-Emulsifying
Drug Delivery System Using Mixedtocotrienols
As The Model Drug |
| title_full_unstemmed |
Formulation Of Solid Self-Emulsifying
Drug Delivery System Using Mixedtocotrienols
As The Model Drug |
| title_sort |
formulation of solid self-emulsifying
drug delivery system using mixedtocotrienols
as the model drug |
| granting_institution |
Perpustakaan Hamzah Sendut |
| granting_department |
Pusat Pengajian Sains Farmasi |
| publishDate |
2020 |
| url |
http://eprints.usm.my/53966/1/LEE%20YOU%20ZHUAN.pdf |
| _version_ |
1747822266451755008 |