The clinical and radiological characterizations of allergic phenotype in chronic rhinosinusitis with nasal polyps

Objectives: Allergic phenotype has recently been described as a subset of chronic rhinosinusitis with polyps (CRSwNP) and without polyps (CRSsNP). Our aim is to explain the clinical characterizations with symptoms and endoscopic Lund Kennedy scoring as well as radiological characterizations with...

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Main Author:	Vengathajalam, Selvamalar
Format:	Thesis
Language:	English
Published:	2020
Subjects:	R Medicine
Online Access:	http://eprints.usm.my/54033/1/Selvamalar-24%20pages.pdf
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spelling	my-usm-ep.540332022-08-14T07:04:13Z The clinical and radiological characterizations of allergic phenotype in chronic rhinosinusitis with nasal polyps 2020 Vengathajalam, Selvamalar R Medicine Objectives: Allergic phenotype has recently been described as a subset of chronic rhinosinusitis with polyps (CRSwNP) and without polyps (CRSsNP). Our aim is to explain the clinical characterizations with symptoms and endoscopic Lund Kennedy scoring as well as radiological characterizations with Lund Mackay scoring of patients with the allergic phenotype of CRSwNP. The importance of this study is to determine the association of allergy and CCAD to CRSwNP that will aid in further understanding of the pathophysiology of the disease and managing the patients accordingly. Methods: A cross-sectional studyon patients diagnosed with CRSwNP who had both allergology and radiological assessments. Theoverall nasal symptoms score including 3 rhinologic problems, with relevance to allergy (need to blow nose, sneezing, and runny nose), Lund Kennedy (LK) endoscopic scoring, Lund Mackay (LM) scoring of computed tomography (CT) scan of the paranasal sinuses (PNS), central compartment atopic disease (CCAD) features, skin prick test (SPT) and level of specific IgE were assessed. Results: There was no difference in overall symptoms score but there was a higher allergy symptoms burden in atopy and CCAD groups. There was significant difference in the endoscopic and CT PNS scores between atopy and non-atopy as well as CCAD and non CCAD. CCAD has a significantly association with atopy and has a higher endoscopic and CT PNS scores. Conclusions: Atopy and its radiological phenotype, the CCAD must be properly assessed in patients with CRSwNP as they may determine the clinical and radiological severity. Patients with atopy and CCAD have more polypoidal involvement of the middle turbinates, additional symptoms burden and higher endoscopic and CT PNS scoring proving that there is an association between allergy and CRSwNP. 2020 Thesis http://eprints.usm.my/54033/ http://eprints.usm.my/54033/1/Selvamalar-24%20pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	R Medicine
spellingShingle	R Medicine Vengathajalam, Selvamalar The clinical and radiological characterizations of allergic phenotype in chronic rhinosinusitis with nasal polyps
description	Objectives: Allergic phenotype has recently been described as a subset of chronic rhinosinusitis with polyps (CRSwNP) and without polyps (CRSsNP). Our aim is to explain the clinical characterizations with symptoms and endoscopic Lund Kennedy scoring as well as radiological characterizations with Lund Mackay scoring of patients with the allergic phenotype of CRSwNP. The importance of this study is to determine the association of allergy and CCAD to CRSwNP that will aid in further understanding of the pathophysiology of the disease and managing the patients accordingly. Methods: A cross-sectional studyon patients diagnosed with CRSwNP who had both allergology and radiological assessments. Theoverall nasal symptoms score including 3 rhinologic problems, with relevance to allergy (need to blow nose, sneezing, and runny nose), Lund Kennedy (LK) endoscopic scoring, Lund Mackay (LM) scoring of computed tomography (CT) scan of the paranasal sinuses (PNS), central compartment atopic disease (CCAD) features, skin prick test (SPT) and level of specific IgE were assessed. Results: There was no difference in overall symptoms score but there was a higher allergy symptoms burden in atopy and CCAD groups. There was significant difference in the endoscopic and CT PNS scores between atopy and non-atopy as well as CCAD and non CCAD. CCAD has a significantly association with atopy and has a higher endoscopic and CT PNS scores. Conclusions: Atopy and its radiological phenotype, the CCAD must be properly assessed in patients with CRSwNP as they may determine the clinical and radiological severity. Patients with atopy and CCAD have more polypoidal involvement of the middle turbinates, additional symptoms burden and higher endoscopic and CT PNS scoring proving that there is an association between allergy and CRSwNP.
format	Thesis
qualification_level	Master's degree
author	Vengathajalam, Selvamalar
author_facet	Vengathajalam, Selvamalar
author_sort	Vengathajalam, Selvamalar
title	The clinical and radiological characterizations of allergic phenotype in chronic rhinosinusitis with nasal polyps
title_short	The clinical and radiological characterizations of allergic phenotype in chronic rhinosinusitis with nasal polyps
title_full	The clinical and radiological characterizations of allergic phenotype in chronic rhinosinusitis with nasal polyps
title_fullStr	The clinical and radiological characterizations of allergic phenotype in chronic rhinosinusitis with nasal polyps
title_full_unstemmed	The clinical and radiological characterizations of allergic phenotype in chronic rhinosinusitis with nasal polyps
title_sort	clinical and radiological characterizations of allergic phenotype in chronic rhinosinusitis with nasal polyps
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2020
url	http://eprints.usm.my/54033/1/Selvamalar-24%20pages.pdf
_version_	1747822272323780608

The clinical and radiological characterizations of allergic phenotype in chronic rhinosinusitis with nasal polyps

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