Validation Of Sgrq-Cm, Risk Factors Of Lung Functions Deterioration And Economic Evaluation In Patients With Chronic Obstructive Pulmonary Disease

Health status and FEV1 decline are two important factors of the GOLD (Global initiative for chronic Obstructive Lung Disease) multidimensional assessment system. This approach uses symptoms based on health status assessment tools, degree of airflow limitation (FEV1) and risk based on exacerbation fr...

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Main Author:	Rehman, Anees Ur
Format:	Thesis
Language:	English
Published:	2020
Subjects:	RS1-441 Pharmacy and materia medica
Online Access:	http://eprints.usm.my/54103/1/ANEES%20UR%20REHMAN.pdf
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id	my-usm-ep.54103
record_format	uketd_dc
spelling	my-usm-ep.541032022-08-16T02:10:02Z Validation Of Sgrq-Cm, Risk Factors Of Lung Functions Deterioration And Economic Evaluation In Patients With Chronic Obstructive Pulmonary Disease 2020-12 Rehman, Anees Ur RS1-441 Pharmacy and materia medica Health status and FEV1 decline are two important factors of the GOLD (Global initiative for chronic Obstructive Lung Disease) multidimensional assessment system. This approach uses symptoms based on health status assessment tools, degree of airflow limitation (FEV1) and risk based on exacerbation frequency to classify patients according to disease severity into four groups GOLD A to D and propose optimum pharmacotherapy. Worsening of health status (increase in symptoms load), decline in FEV1 or increase in exacerbation frequency can result in progression of disease from lower to higher group. COPD is also associated with considerable economic burden on the individual and society. Thus, objectives of the current study were to assess the economic burden of COPD, validate the Malaysian version of St George's Respiratory COPD specific questionnaire (SGRQ-CM) as health status assessment tool and find the risk factors of FEV1 decline in COPD patients. This was a longitudinal prospective cohort including 367 COPD patients from Penang Hospital. Validity, reliability, responsiveness and MCID (minimum clinical important difference) of the of the Malaysian version of SGRQ-C was assessed to be used in population of Malaysia. Univariate and multivariate Cox regression with robust variance were performed to estimate relative risk (RR) for different factors on decline in FEV1 after one year of follow up. Activity-Based Costing, bottom-up approach was used to calculate direct cost, while, indirect costs of the patients were assessed using the Work Productivity and Activity Impairment Questionnaire. 2020-12 Thesis http://eprints.usm.my/54103/ http://eprints.usm.my/54103/1/ANEES%20UR%20REHMAN.pdf application/pdf en public phd doctoral Perpustakaan Hamzah Sendut Pusat Pengajian Sains Farmasi
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RS1-441 Pharmacy and materia medica
spellingShingle	RS1-441 Pharmacy and materia medica Rehman, Anees Ur Validation Of Sgrq-Cm, Risk Factors Of Lung Functions Deterioration And Economic Evaluation In Patients With Chronic Obstructive Pulmonary Disease
description	Health status and FEV1 decline are two important factors of the GOLD (Global initiative for chronic Obstructive Lung Disease) multidimensional assessment system. This approach uses symptoms based on health status assessment tools, degree of airflow limitation (FEV1) and risk based on exacerbation frequency to classify patients according to disease severity into four groups GOLD A to D and propose optimum pharmacotherapy. Worsening of health status (increase in symptoms load), decline in FEV1 or increase in exacerbation frequency can result in progression of disease from lower to higher group. COPD is also associated with considerable economic burden on the individual and society. Thus, objectives of the current study were to assess the economic burden of COPD, validate the Malaysian version of St George's Respiratory COPD specific questionnaire (SGRQ-CM) as health status assessment tool and find the risk factors of FEV1 decline in COPD patients. This was a longitudinal prospective cohort including 367 COPD patients from Penang Hospital. Validity, reliability, responsiveness and MCID (minimum clinical important difference) of the of the Malaysian version of SGRQ-C was assessed to be used in population of Malaysia. Univariate and multivariate Cox regression with robust variance were performed to estimate relative risk (RR) for different factors on decline in FEV1 after one year of follow up. Activity-Based Costing, bottom-up approach was used to calculate direct cost, while, indirect costs of the patients were assessed using the Work Productivity and Activity Impairment Questionnaire.
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Rehman, Anees Ur
author_facet	Rehman, Anees Ur
author_sort	Rehman, Anees Ur
title	Validation Of Sgrq-Cm, Risk Factors Of Lung Functions Deterioration And Economic Evaluation In Patients With Chronic Obstructive Pulmonary Disease
title_short	Validation Of Sgrq-Cm, Risk Factors Of Lung Functions Deterioration And Economic Evaluation In Patients With Chronic Obstructive Pulmonary Disease
title_full	Validation Of Sgrq-Cm, Risk Factors Of Lung Functions Deterioration And Economic Evaluation In Patients With Chronic Obstructive Pulmonary Disease
title_fullStr	Validation Of Sgrq-Cm, Risk Factors Of Lung Functions Deterioration And Economic Evaluation In Patients With Chronic Obstructive Pulmonary Disease
title_full_unstemmed	Validation Of Sgrq-Cm, Risk Factors Of Lung Functions Deterioration And Economic Evaluation In Patients With Chronic Obstructive Pulmonary Disease
title_sort	validation of sgrq-cm, risk factors of lung functions deterioration and economic evaluation in patients with chronic obstructive pulmonary disease
granting_institution	Perpustakaan Hamzah Sendut
granting_department	Pusat Pengajian Sains Farmasi
publishDate	2020
url	http://eprints.usm.my/54103/1/ANEES%20UR%20REHMAN.pdf
_version_	1747822274544664576

Validation Of Sgrq-Cm, Risk Factors Of Lung Functions Deterioration And Economic Evaluation In Patients With Chronic Obstructive Pulmonary Disease

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