Association between vitamin d and obesity related adipokines with breast cancer occurrence among women patients in Kelantan

Breast cancer is a common carcinoma diagnosed among women worldwide as well as Malaysia. Numerous studies reported the association between vitamin D and obesity related adipokines with breast cancer development, yet the possible roles of these risk factors remain scarce. Hence, the objective of t...

Full description

Saved in:

Bibliographic Details
Main Author:	Zahali, Zunura'in
Format:	Thesis
Language:	English
Published:	2022
Subjects:	R Medicine
Online Access:	http://eprints.usm.my/54671/1/ZUNURA%27IN%20BINTI%20ZAHALI-FINAL%20THESIS%20S-SKD000314%28R%29%20PWD_-24%20pages.pdf
Tags:	Add Tag No Tags, Be the first to tag this record!

id	my-usm-ep.54671
record_format	uketd_dc
spelling	my-usm-ep.546712022-09-14T06:58:29Z Association between vitamin d and obesity related adipokines with breast cancer occurrence among women patients in Kelantan 2022-06 Zahali, Zunura'in R Medicine Breast cancer is a common carcinoma diagnosed among women worldwide as well as Malaysia. Numerous studies reported the association between vitamin D and obesity related adipokines with breast cancer development, yet the possible roles of these risk factors remain scarce. Hence, the objective of this study was to determine the association between serum vitamin D and obesity related adipokines (HMW adiponectin and visfatin) with the development of breast cancer. This study was carried out in Kelantan, Malaysia from July 2014 until June 2017. A case-control study was conducted as a baseline recruitment and continued with follow-up of breast cancer women at 18 months post-diagnosis. At baseline 78 newly-diagnosed breast cancer patients and 85 healthy women aged 21 to 59 years old enrolled in this study. Data collection consisted of socio-demographics, reproductives history, anthropometrics and blood pressure measurement, as well as clinical biochemistry analysis. Multiple logistic regression analysis showed that cotinine (OR = 1.22; 95% CI: 1.02, 1.48), waist circumference (WC) (OR = 1.10; 95% CI: 1.02, 1.20), trigliseride (TG) (OR = 4.93; 95% CI: 1.83, 13.2) and fasting glucose (OR = 1.90; 95% CI: 1.25, 2.89) were significantly associated with increased risk of breast cancer. Serum vitamin D (OR = 0.89; 95% CI: 0.83, 0.95) and high molecular weight (HMW) adiponectin (OR = 0.76, 95% CI: 0.59, 0.98) were significantly related with decreased risk of breast cancer development. However, there was no significant association between Vitamin D receptor (VDR) polymorphism (FokI, BsmI and TaqI) with breast cancer was observed. 2022-06 Thesis http://eprints.usm.my/54671/ http://eprints.usm.my/54671/1/ZUNURA%27IN%20BINTI%20ZAHALI-FINAL%20THESIS%20S-SKD000314%28R%29%20PWD_-24%20pages.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	R Medicine
spellingShingle	R Medicine Zahali, Zunura'in Association between vitamin d and obesity related adipokines with breast cancer occurrence among women patients in Kelantan
description	Breast cancer is a common carcinoma diagnosed among women worldwide as well as Malaysia. Numerous studies reported the association between vitamin D and obesity related adipokines with breast cancer development, yet the possible roles of these risk factors remain scarce. Hence, the objective of this study was to determine the association between serum vitamin D and obesity related adipokines (HMW adiponectin and visfatin) with the development of breast cancer. This study was carried out in Kelantan, Malaysia from July 2014 until June 2017. A case-control study was conducted as a baseline recruitment and continued with follow-up of breast cancer women at 18 months post-diagnosis. At baseline 78 newly-diagnosed breast cancer patients and 85 healthy women aged 21 to 59 years old enrolled in this study. Data collection consisted of socio-demographics, reproductives history, anthropometrics and blood pressure measurement, as well as clinical biochemistry analysis. Multiple logistic regression analysis showed that cotinine (OR = 1.22; 95% CI: 1.02, 1.48), waist circumference (WC) (OR = 1.10; 95% CI: 1.02, 1.20), trigliseride (TG) (OR = 4.93; 95% CI: 1.83, 13.2) and fasting glucose (OR = 1.90; 95% CI: 1.25, 2.89) were significantly associated with increased risk of breast cancer. Serum vitamin D (OR = 0.89; 95% CI: 0.83, 0.95) and high molecular weight (HMW) adiponectin (OR = 0.76, 95% CI: 0.59, 0.98) were significantly related with decreased risk of breast cancer development. However, there was no significant association between Vitamin D receptor (VDR) polymorphism (FokI, BsmI and TaqI) with breast cancer was observed.
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Zahali, Zunura'in
author_facet	Zahali, Zunura'in
author_sort	Zahali, Zunura'in
title	Association between vitamin d and obesity related adipokines with breast cancer occurrence among women patients in Kelantan
title_short	Association between vitamin d and obesity related adipokines with breast cancer occurrence among women patients in Kelantan
title_full	Association between vitamin d and obesity related adipokines with breast cancer occurrence among women patients in Kelantan
title_fullStr	Association between vitamin d and obesity related adipokines with breast cancer occurrence among women patients in Kelantan
title_full_unstemmed	Association between vitamin d and obesity related adipokines with breast cancer occurrence among women patients in Kelantan
title_sort	association between vitamin d and obesity related adipokines with breast cancer occurrence among women patients in kelantan
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2022
url	http://eprints.usm.my/54671/1/ZUNURA%27IN%20BINTI%20ZAHALI-FINAL%20THESIS%20S-SKD000314%28R%29%20PWD_-24%20pages.pdf
_version_	1747822289990189056

Association between vitamin d and obesity related adipokines with breast cancer occurrence among women patients in Kelantan

Similar Items