Properties Of Bioactive Glass Reinforced Polyurethane Scaffold By Solvent Casting/Particulate Leaching Method

The properties of polyurethane-Bioglass® (PU-BG) scaffolds have been optimized using solvent casting/particulate leaching (SC/PL) method. Processing parameters such as polymer solution concentration (15, 16, 17, 18 and 19 wt/vol%), leaching agent concentration with ratio between PU and NaCl (1:3, 1:...

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Main Author:	Suhaimin, Intan Syazana
Format:	Thesis
Language:	English
Published:	2019
Subjects:	T Technology
Online Access:	http://eprints.usm.my/55186/1/Properties%20Of%20Bioactive%20Glass%20Reinforced%20Polyurethane%20Scaffold%20By%20Solvent%20CastingParticulate%20Leaching%20Method_Intan%20Syazana%20Suhaimin_B1_2019_ESAR.pdf
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spelling	my-usm-ep.551862022-10-06T07:14:46Z Properties Of Bioactive Glass Reinforced Polyurethane Scaffold By Solvent Casting/Particulate Leaching Method 2019-08-01 Suhaimin, Intan Syazana T Technology TN Mining Engineering. Metallurgy The properties of polyurethane-Bioglass® (PU-BG) scaffolds have been optimized using solvent casting/particulate leaching (SC/PL) method. Processing parameters such as polymer solution concentration (15, 16, 17, 18 and 19 wt/vol%), leaching agent concentration with ratio between PU and NaCl (1:3, 1:4, 1:5, 1:6 and 1:7), leaching agent composition by percentage of NaCl/NaHCO3 (100/0, 85/15, 75/25, 65/35, 55/45 and 45/55) and percentage of Bioglass® (0, 10, 20, 30 40 and 50 wt%) were investigated to obtain the desired properties of PU-BG scaffolds. The scaffolds were characterized using field emission scanning electron microscopic (FESEM), porosity test, fourier transform infrared (FTIR), compression test, inductively coupled plasma (ICP) and degradation test. The optimum parameters to fabricate PU-BG scaffold were found to be 19 wt/vol % of polymer solution concentration, 1:6 ratio (PU: NaCl) of leaching agent concentration and leaching agent composition between 65% NaCl and 35% NaHCO3. The optimization process was able to fabricate the composite scaffold with the thickness more than 20 mm without the formation of undesirable dense layer. Besides, the PU-BG scaffolds were observed with well interconnected porous structure with the pore size spanning over a wide range and adequate porosity for the bone tissue application. The results demonstrated that, the increased in percentage of Bioglass® from 0 wt% to 50 wt% was found to improve the compressive strength as well as induced and accelerated an apatite formation during in-vitro test. 2019-08 Thesis http://eprints.usm.my/55186/ http://eprints.usm.my/55186/1/Properties%20Of%20Bioactive%20Glass%20Reinforced%20Polyurethane%20Scaffold%20By%20Solvent%20CastingParticulate%20Leaching%20Method_Intan%20Syazana%20Suhaimin_B1_2019_ESAR.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Kejuruteraan Bahan dan Sumber Mineral
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	T Technology T Technology
spellingShingle	T Technology T Technology Suhaimin, Intan Syazana Properties Of Bioactive Glass Reinforced Polyurethane Scaffold By Solvent Casting/Particulate Leaching Method
description	The properties of polyurethane-Bioglass® (PU-BG) scaffolds have been optimized using solvent casting/particulate leaching (SC/PL) method. Processing parameters such as polymer solution concentration (15, 16, 17, 18 and 19 wt/vol%), leaching agent concentration with ratio between PU and NaCl (1:3, 1:4, 1:5, 1:6 and 1:7), leaching agent composition by percentage of NaCl/NaHCO3 (100/0, 85/15, 75/25, 65/35, 55/45 and 45/55) and percentage of Bioglass® (0, 10, 20, 30 40 and 50 wt%) were investigated to obtain the desired properties of PU-BG scaffolds. The scaffolds were characterized using field emission scanning electron microscopic (FESEM), porosity test, fourier transform infrared (FTIR), compression test, inductively coupled plasma (ICP) and degradation test. The optimum parameters to fabricate PU-BG scaffold were found to be 19 wt/vol % of polymer solution concentration, 1:6 ratio (PU: NaCl) of leaching agent concentration and leaching agent composition between 65% NaCl and 35% NaHCO3. The optimization process was able to fabricate the composite scaffold with the thickness more than 20 mm without the formation of undesirable dense layer. Besides, the PU-BG scaffolds were observed with well interconnected porous structure with the pore size spanning over a wide range and adequate porosity for the bone tissue application. The results demonstrated that, the increased in percentage of Bioglass® from 0 wt% to 50 wt% was found to improve the compressive strength as well as induced and accelerated an apatite formation during in-vitro test.
format	Thesis
qualification_level	Master's degree
author	Suhaimin, Intan Syazana
author_facet	Suhaimin, Intan Syazana
author_sort	Suhaimin, Intan Syazana
title	Properties Of Bioactive Glass Reinforced Polyurethane Scaffold By Solvent Casting/Particulate Leaching Method
title_short	Properties Of Bioactive Glass Reinforced Polyurethane Scaffold By Solvent Casting/Particulate Leaching Method
title_full	Properties Of Bioactive Glass Reinforced Polyurethane Scaffold By Solvent Casting/Particulate Leaching Method
title_fullStr	Properties Of Bioactive Glass Reinforced Polyurethane Scaffold By Solvent Casting/Particulate Leaching Method
title_full_unstemmed	Properties Of Bioactive Glass Reinforced Polyurethane Scaffold By Solvent Casting/Particulate Leaching Method
title_sort	properties of bioactive glass reinforced polyurethane scaffold by solvent casting/particulate leaching method
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Kejuruteraan Bahan dan Sumber Mineral
publishDate	2019
url	http://eprints.usm.my/55186/1/Properties%20Of%20Bioactive%20Glass%20Reinforced%20Polyurethane%20Scaffold%20By%20Solvent%20CastingParticulate%20Leaching%20Method_Intan%20Syazana%20Suhaimin_B1_2019_ESAR.pdf
_version_	1747822318880555008

Properties Of Bioactive Glass Reinforced Polyurethane Scaffold By Solvent Casting/Particulate Leaching Method

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