The Evaluation Of The Toxic Effect Of And Its Paraquat Mechanism Of Action On Reproductive System Of Male Rats
Paraquat‘r") - PQ (1.1’ — dimethyl 4.4' - bipyridillium dichloride) is a nonselective contact herbicide. Its herbicidal and toxicological properties are dependent on the ability of the parent cation to undergo a single electron addition to form a free radical. The present study was cond...
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2007
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my-usm-ep.552452022-10-11T07:25:07Z The Evaluation Of The Toxic Effect Of And Its Paraquat Mechanism Of Action On Reproductive System Of Male Rats 2007-05 Zain, Anuar Md. RA1190-1270 Toxicology. Poisons Paraquat‘r") - PQ (1.1’ — dimethyl 4.4' - bipyridillium dichloride) is a nonselective contact herbicide. Its herbicidal and toxicological properties are dependent on the ability of the parent cation to undergo a single electron addition to form a free radical. The present study was conducted to evaluate the toxic effect of low dose of PO and its mechanism of action on the reproductive system of adult male rats. Two routes of administration were selected; oral and dermal which are the most common exposure routes in human being Groups of six male Sprague-Dawley rats (n=6) were orally gavaged in selected dose of 2mg/kg. 5mg/kg and 20mg/kg (1/80, 1/32 and 1/8 of oral LD50) and dermally applied in selected dose of 6mg/kg, 15mg/kg and 30mg/kg (1/15, 1/6. and 1/3 of dermal LD50) for five consecutive days separately and scheduled for 7, 28. 42, 84 and 105 days for oral, and 7, 14. 28 and 42 days for dermal applications in separate groups after the last dose, Body weight did not show any change in the treated groups compared to the control. 2007-05 Thesis http://eprints.usm.my/55245/ http://eprints.usm.my/55245/1/the%20evoluation%20of%20the%20toxic_copy.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan |
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Universiti Sains Malaysia |
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USM Institutional Repository |
| language |
English |
| topic |
RA1190-1270 Toxicology Poisons |
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RA1190-1270 Toxicology Poisons Zain, Anuar Md. The Evaluation Of The Toxic Effect Of And Its Paraquat Mechanism Of Action On Reproductive System Of Male Rats |
| description |
Paraquat‘r") - PQ (1.1’ — dimethyl 4.4' - bipyridillium dichloride) is a nonselective
contact herbicide. Its herbicidal and toxicological properties are
dependent on the ability of the parent cation to undergo a single electron
addition to form a free radical. The present study was conducted to evaluate
the toxic effect of low dose of PO and its mechanism of action on the
reproductive system of adult male rats. Two routes of administration were
selected; oral and dermal which are the most common exposure routes in
human being Groups of six male Sprague-Dawley rats (n=6) were orally
gavaged in selected dose of 2mg/kg. 5mg/kg and 20mg/kg (1/80, 1/32 and 1/8
of oral LD50) and dermally applied in selected dose of 6mg/kg, 15mg/kg and
30mg/kg (1/15, 1/6. and 1/3 of dermal LD50) for five consecutive days
separately and scheduled for 7, 28. 42, 84 and 105 days for oral, and 7, 14.
28 and 42 days for dermal applications in separate groups after the last dose,
Body weight did not show any change in the treated groups compared to the
control. |
| format |
Thesis |
| qualification_level |
Master's degree |
| author |
Zain, Anuar Md. |
| author_facet |
Zain, Anuar Md. |
| author_sort |
Zain, Anuar Md. |
| title |
The Evaluation Of The Toxic Effect Of And Its Paraquat Mechanism Of Action On
Reproductive System Of Male Rats |
| title_short |
The Evaluation Of The Toxic Effect Of And Its Paraquat Mechanism Of Action On
Reproductive System Of Male Rats |
| title_full |
The Evaluation Of The Toxic Effect Of And Its Paraquat Mechanism Of Action On
Reproductive System Of Male Rats |
| title_fullStr |
The Evaluation Of The Toxic Effect Of And Its Paraquat Mechanism Of Action On
Reproductive System Of Male Rats |
| title_full_unstemmed |
The Evaluation Of The Toxic Effect Of And Its Paraquat Mechanism Of Action On
Reproductive System Of Male Rats |
| title_sort |
evaluation of the toxic effect of and its paraquat mechanism of action on
reproductive system of male rats |
| granting_institution |
Universiti Sains Malaysia |
| granting_department |
Pusat Pengajian Sains Perubatan |
| publishDate |
2007 |
| url |
http://eprints.usm.my/55245/1/the%20evoluation%20of%20the%20toxic_copy.pdf |
| _version_ |
1747822320576102400 |