Synthesis, Characterization And Anti-Mycobacterial Activity Of New 1,3,4-Oxadiazole Derivatives

A total of 20 new 2-alkylbenzysulfanyl-5-substituted-1,3,4-oxadiazoles derivatives (5a-j and 6a-j) were synthesized in four-step reaction pathways from carboxylic acid analogues as the starting materials, with moderate (40%) to excellent yields (92 %). These compounds continued a wide range of subst...

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Main Author:	Hasmaruddin, Nurul Syazana
Format:	Thesis
Language:	English
Published:	2020
Subjects:	QD1-65 General Including alchemy
Online Access:	http://eprints.usm.my/55580/1/NURUL%20SYAZANA%20HASMARUDDIN%20cut.pdf
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spelling	my-usm-ep.555802022-11-09T07:21:33Z Synthesis, Characterization And Anti-Mycobacterial Activity Of New 1,3,4-Oxadiazole Derivatives 2020-03 Hasmaruddin, Nurul Syazana QD1-65 General Including alchemy A total of 20 new 2-alkylbenzysulfanyl-5-substituted-1,3,4-oxadiazoles derivatives (5a-j and 6a-j) were synthesized in four-step reaction pathways from carboxylic acid analogues as the starting materials, with moderate (40%) to excellent yields (92 %). These compounds continued a wide range of substituents including electron donating as well as electron-withdrawing groups. All these compounds were characterized using Fourier Transform Infrared (FT-IR) and Nuclear Magnetic Resonance (NMR) spectroscopy and elemental analysis. Some of the synthesized compounds were assayed for anti-mycobacterial activity against surrogate tuberculosis organisms (Mycobacterium smegmatis and Mycobacterium tuberculosis H3Ra). Fourteen compounds exhibited inhibition against M. smegmatis with MIC values in the range of 25-1600 μg/mL. Results of anti-mycobacterial assay against M. smegmatis showed that only 5c and 5d had good inhibition with MIC and MBC values of 78 μM and 68 μM, respectively. Some of the compounds showed moderate to weak inhibition. Interaction study of the respective compounds 5c and 5d with isoniazid against M. smegmatis using the checkerboard method produced an additive interaction. The time-kill assay on the combination of compounds 5c and 5d with INH against M. smegmatis produced a higher killing rate compared to drug INH at the end of the period of study which are 88.22 % and 77.10 %, respectively. Therefore, compounds 5c and 5d are potential anti-tuberculosis drug candidates. 2020-03 Thesis http://eprints.usm.my/55580/ http://eprints.usm.my/55580/1/NURUL%20SYAZANA%20HASMARUDDIN%20cut.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Kimia
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	QD1-65 General Including alchemy
spellingShingle	QD1-65 General Including alchemy Hasmaruddin, Nurul Syazana Synthesis, Characterization And Anti-Mycobacterial Activity Of New 1,3,4-Oxadiazole Derivatives
description	A total of 20 new 2-alkylbenzysulfanyl-5-substituted-1,3,4-oxadiazoles derivatives (5a-j and 6a-j) were synthesized in four-step reaction pathways from carboxylic acid analogues as the starting materials, with moderate (40%) to excellent yields (92 %). These compounds continued a wide range of substituents including electron donating as well as electron-withdrawing groups. All these compounds were characterized using Fourier Transform Infrared (FT-IR) and Nuclear Magnetic Resonance (NMR) spectroscopy and elemental analysis. Some of the synthesized compounds were assayed for anti-mycobacterial activity against surrogate tuberculosis organisms (Mycobacterium smegmatis and Mycobacterium tuberculosis H3Ra). Fourteen compounds exhibited inhibition against M. smegmatis with MIC values in the range of 25-1600 μg/mL. Results of anti-mycobacterial assay against M. smegmatis showed that only 5c and 5d had good inhibition with MIC and MBC values of 78 μM and 68 μM, respectively. Some of the compounds showed moderate to weak inhibition. Interaction study of the respective compounds 5c and 5d with isoniazid against M. smegmatis using the checkerboard method produced an additive interaction. The time-kill assay on the combination of compounds 5c and 5d with INH against M. smegmatis produced a higher killing rate compared to drug INH at the end of the period of study which are 88.22 % and 77.10 %, respectively. Therefore, compounds 5c and 5d are potential anti-tuberculosis drug candidates.
format	Thesis
qualification_level	Master's degree
author	Hasmaruddin, Nurul Syazana
author_facet	Hasmaruddin, Nurul Syazana
author_sort	Hasmaruddin, Nurul Syazana
title	Synthesis, Characterization And Anti-Mycobacterial Activity Of New 1,3,4-Oxadiazole Derivatives
title_short	Synthesis, Characterization And Anti-Mycobacterial Activity Of New 1,3,4-Oxadiazole Derivatives
title_full	Synthesis, Characterization And Anti-Mycobacterial Activity Of New 1,3,4-Oxadiazole Derivatives
title_fullStr	Synthesis, Characterization And Anti-Mycobacterial Activity Of New 1,3,4-Oxadiazole Derivatives
title_full_unstemmed	Synthesis, Characterization And Anti-Mycobacterial Activity Of New 1,3,4-Oxadiazole Derivatives
title_sort	synthesis, characterization and anti-mycobacterial activity of new 1,3,4-oxadiazole derivatives
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Kimia
publishDate	2020
url	http://eprints.usm.my/55580/1/NURUL%20SYAZANA%20HASMARUDDIN%20cut.pdf
_version_	1776101095729266688

Synthesis, Characterization And Anti-Mycobacterial Activity Of New 1,3,4-Oxadiazole Derivatives

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