Pluronic F-127 Coated Zinc Oxide Nanoparticles Cytotoxicity And Their Photodynamic Therapy Towards Human Rt4 Urinary Bladder Cancer Cell Lines

Bladder cancer is the most common malignancy of the urinary system and one of the ten most common cancers that can affect the whole-body. Photodynamic therapy (PDT) holds promising applications in cancer treatment with high selectivity and minimum side effects. However, the current clinically approv...

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Main Author:	Soud Abuelsamen, Abdulsalam Ali
Format:	Thesis
Language:	English
Published:	2019
Subjects:	QC1 Physics (General)
Online Access:	http://eprints.usm.my/55670/1/24%20Pages%20from%20Abdulsalam%20Ali.pdf
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id	my-usm-ep.55670
record_format	uketd_dc
spelling	my-usm-ep.556702022-11-16T03:34:36Z Pluronic F-127 Coated Zinc Oxide Nanoparticles Cytotoxicity And Their Photodynamic Therapy Towards Human Rt4 Urinary Bladder Cancer Cell Lines 2019-11 Soud Abuelsamen, Abdulsalam Ali QC1 Physics (General) Bladder cancer is the most common malignancy of the urinary system and one of the ten most common cancers that can affect the whole-body. Photodynamic therapy (PDT) holds promising applications in cancer treatment with high selectivity and minimum side effects. However, the current clinically approved photosensitizers have several drawbacks with limited tumour selectivity that affects the healthy normal cells. Zinc oxide nanoparticles (ZnO NPs) have exhibited promising potential in various biomedical applications including cancer therapy. In this study, for the first time, the potential of bare and Pluronic coated ZnO NPs as photosensitizers for effective photodynamic therapy against bladder cancer RT4 cell line were systematically investigated. The FESEM and TEM results revealed that Pluronic F-127 coated ZnO NPs had an average size of 80 nm whereby the Pluronic F-127 coating layer thickness ranged from 3 nm to 7 nm. 2019-11 Thesis http://eprints.usm.my/55670/ http://eprints.usm.my/55670/1/24%20Pages%20from%20Abdulsalam%20Ali.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Pusat Pengajian Sains Fizik
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	QC1 Physics (General)
spellingShingle	QC1 Physics (General) Soud Abuelsamen, Abdulsalam Ali Pluronic F-127 Coated Zinc Oxide Nanoparticles Cytotoxicity And Their Photodynamic Therapy Towards Human Rt4 Urinary Bladder Cancer Cell Lines
description	Bladder cancer is the most common malignancy of the urinary system and one of the ten most common cancers that can affect the whole-body. Photodynamic therapy (PDT) holds promising applications in cancer treatment with high selectivity and minimum side effects. However, the current clinically approved photosensitizers have several drawbacks with limited tumour selectivity that affects the healthy normal cells. Zinc oxide nanoparticles (ZnO NPs) have exhibited promising potential in various biomedical applications including cancer therapy. In this study, for the first time, the potential of bare and Pluronic coated ZnO NPs as photosensitizers for effective photodynamic therapy against bladder cancer RT4 cell line were systematically investigated. The FESEM and TEM results revealed that Pluronic F-127 coated ZnO NPs had an average size of 80 nm whereby the Pluronic F-127 coating layer thickness ranged from 3 nm to 7 nm.
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Soud Abuelsamen, Abdulsalam Ali
author_facet	Soud Abuelsamen, Abdulsalam Ali
author_sort	Soud Abuelsamen, Abdulsalam Ali
title	Pluronic F-127 Coated Zinc Oxide Nanoparticles Cytotoxicity And Their Photodynamic Therapy Towards Human Rt4 Urinary Bladder Cancer Cell Lines
title_short	Pluronic F-127 Coated Zinc Oxide Nanoparticles Cytotoxicity And Their Photodynamic Therapy Towards Human Rt4 Urinary Bladder Cancer Cell Lines
title_full	Pluronic F-127 Coated Zinc Oxide Nanoparticles Cytotoxicity And Their Photodynamic Therapy Towards Human Rt4 Urinary Bladder Cancer Cell Lines
title_fullStr	Pluronic F-127 Coated Zinc Oxide Nanoparticles Cytotoxicity And Their Photodynamic Therapy Towards Human Rt4 Urinary Bladder Cancer Cell Lines
title_full_unstemmed	Pluronic F-127 Coated Zinc Oxide Nanoparticles Cytotoxicity And Their Photodynamic Therapy Towards Human Rt4 Urinary Bladder Cancer Cell Lines
title_sort	pluronic f-127 coated zinc oxide nanoparticles cytotoxicity and their photodynamic therapy towards human rt4 urinary bladder cancer cell lines
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Fizik
publishDate	2019
url	http://eprints.usm.my/55670/1/24%20Pages%20from%20Abdulsalam%20Ali.pdf
_version_	1776101105102487552

Pluronic F-127 Coated Zinc Oxide Nanoparticles Cytotoxicity And Their Photodynamic Therapy Towards Human Rt4 Urinary Bladder Cancer Cell Lines

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