Synthesis And Characterisation Of New Dispiro Pyrrolidines As Cholinesterase Inhibitors

Spiro compounds are widely known for their diverse biological activities and become an important target by researchers to study and to produce synthetically. Alzheimer’s disease known as a neurodegenerative disorder with its number of cases reported increases every year worldwide. With available tre...

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Main Author:	Mohamed Yusoff, Nadia
Format:	Thesis
Language:	English
Published:	2019
Subjects:	QD1-999 Chemistry
Online Access:	http://eprints.usm.my/55728/1/24%20Pages%20from%20Nadia%20Mohamed%20Yusoff.pdf
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id	my-usm-ep.55728
record_format	uketd_dc
spelling	my-usm-ep.557282022-11-23T04:30:09Z Synthesis And Characterisation Of New Dispiro Pyrrolidines As Cholinesterase Inhibitors 2019-12 Mohamed Yusoff, Nadia QD1-999 Chemistry Spiro compounds are widely known for their diverse biological activities and become an important target by researchers to study and to produce synthetically. Alzheimer’s disease known as a neurodegenerative disorder with its number of cases reported increases every year worldwide. With available treatments that are only able to slow down the symptoms, there is an urgent need to continue developing more efficient drugs in targeting the cholinesterase enzymes activities inhibition. In this study, three dienones derivatives, 3,5-bis(arylidene)-1-phenylethyl-4-piperidone (19-21) and fifteen new spiro heterocycles are known as dispiro pyrrolidines (22-24) were successfully synthesised afforded in good yield with a range of 85.4-94.6 and 81.3-98.1 %, respectively. 2019-12 Thesis http://eprints.usm.my/55728/ http://eprints.usm.my/55728/1/24%20Pages%20from%20Nadia%20Mohamed%20Yusoff.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Kimia
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	QD1-999 Chemistry
spellingShingle	QD1-999 Chemistry Mohamed Yusoff, Nadia Synthesis And Characterisation Of New Dispiro Pyrrolidines As Cholinesterase Inhibitors
description	Spiro compounds are widely known for their diverse biological activities and become an important target by researchers to study and to produce synthetically. Alzheimer’s disease known as a neurodegenerative disorder with its number of cases reported increases every year worldwide. With available treatments that are only able to slow down the symptoms, there is an urgent need to continue developing more efficient drugs in targeting the cholinesterase enzymes activities inhibition. In this study, three dienones derivatives, 3,5-bis(arylidene)-1-phenylethyl-4-piperidone (19-21) and fifteen new spiro heterocycles are known as dispiro pyrrolidines (22-24) were successfully synthesised afforded in good yield with a range of 85.4-94.6 and 81.3-98.1 %, respectively.
format	Thesis
qualification_level	Master's degree
author	Mohamed Yusoff, Nadia
author_facet	Mohamed Yusoff, Nadia
author_sort	Mohamed Yusoff, Nadia
title	Synthesis And Characterisation Of New Dispiro Pyrrolidines As Cholinesterase Inhibitors
title_short	Synthesis And Characterisation Of New Dispiro Pyrrolidines As Cholinesterase Inhibitors
title_full	Synthesis And Characterisation Of New Dispiro Pyrrolidines As Cholinesterase Inhibitors
title_fullStr	Synthesis And Characterisation Of New Dispiro Pyrrolidines As Cholinesterase Inhibitors
title_full_unstemmed	Synthesis And Characterisation Of New Dispiro Pyrrolidines As Cholinesterase Inhibitors
title_sort	synthesis and characterisation of new dispiro pyrrolidines as cholinesterase inhibitors
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Kimia
publishDate	2019
url	http://eprints.usm.my/55728/1/24%20Pages%20from%20Nadia%20Mohamed%20Yusoff.pdf
_version_	1776101109423669248

Synthesis And Characterisation Of New Dispiro Pyrrolidines As Cholinesterase Inhibitors

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