Synthesis, Characterization And Properties Of Chitosan-Poly (Methacrylic Acid-Co-N-Isopropylacrylamide) Hydrogel For Drug Delivery

The application of chitosan has received enormous attention in medical field particularly in drug delivery. In this study, chitosan with two monomers, methacrylic acid (MAA) and N-isopropylacrylamide (NIPAM) were prepared by emulsion polymerization to form a chitosan-poly(methacrylic acid-co-N-isopr...

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Main Author:	Md Rasib, Siti Zalifah
Format:	Thesis
Language:	English
Published:	2019
Subjects:	T Technology
Online Access:	http://eprints.usm.my/56156/1/Synthesis%2C%20Characterization%20And%20Properties%20Of%20Chitosan-Poly%20%28Methacrylic%20Acid-Co-N-Isopropylacrylamide%29%20Hydrogel%20For%20Drug%20Delivery_Siti%20Zalifah%20Md%20Rasib.pdf
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spelling	my-usm-ep.561562022-12-29T09:06:37Z Synthesis, Characterization And Properties Of Chitosan-Poly (Methacrylic Acid-Co-N-Isopropylacrylamide) Hydrogel For Drug Delivery 2019-05-01 Md Rasib, Siti Zalifah T Technology TN Mining Engineering. Metallurgy The application of chitosan has received enormous attention in medical field particularly in drug delivery. In this study, chitosan with two monomers, methacrylic acid (MAA) and N-isopropylacrylamide (NIPAM) were prepared by emulsion polymerization to form a chitosan-poly(methacrylic acid-co-N-isopropylacrylamide) (chitosan-p(MAA-co-NIPAM)) hydrogel as a drug carrier. Hydrogels were characterized using Fourier Transform Infrared (FTIR) Spectroscopy, Carbon-13 Nuclear Magnetic Resonance (13C-NMR), Field Emission Scanning Electron Microscope (FESEM), particle size analysis and Dynamic Light Scattering (DLS). The effect of stimuli responsive (pH and temperature), hydrolysis, drug loading, in-vitro drug release and cytotoxicity was investigated. The finding found that chitosan-p(MAA-co-NIPAM) hydrogel synthesized using surfactant (Span 80) successfully achieved particle size less than 500 nm. The cationic surface charge of synthesis hydrogel passed the stability requirement to avoid aggregation in blood system above 30 mV at pH 3 to 5 and potentially enhanced cellular internalization drug delivery up to pH 6. The release of Rifampicin drug was controlled by combination of diffusion and swelling as the drug released was prolonged to 72 hours indicating that the hydrogel responded to the pH and temperature environment. High viability cell from cytotoxicity assessment demonstrated that the hydrogels are human/animal friendly biomaterials. Thus, it can be concluded that chitosan-p(MAA-co-NIPAM) hydrogels are feasible as controlled drug delivery carrier. 2019-05 Thesis http://eprints.usm.my/56156/ http://eprints.usm.my/56156/1/Synthesis%2C%20Characterization%20And%20Properties%20Of%20Chitosan-Poly%20%28Methacrylic%20Acid-Co-N-Isopropylacrylamide%29%20Hydrogel%20For%20Drug%20Delivery_Siti%20Zalifah%20Md%20Rasib.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Pusat Pengajian Kejuruteraan Bahan dan Sumber Mineral
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	T Technology T Technology
spellingShingle	T Technology T Technology Md Rasib, Siti Zalifah Synthesis, Characterization And Properties Of Chitosan-Poly (Methacrylic Acid-Co-N-Isopropylacrylamide) Hydrogel For Drug Delivery
description	The application of chitosan has received enormous attention in medical field particularly in drug delivery. In this study, chitosan with two monomers, methacrylic acid (MAA) and N-isopropylacrylamide (NIPAM) were prepared by emulsion polymerization to form a chitosan-poly(methacrylic acid-co-N-isopropylacrylamide) (chitosan-p(MAA-co-NIPAM)) hydrogel as a drug carrier. Hydrogels were characterized using Fourier Transform Infrared (FTIR) Spectroscopy, Carbon-13 Nuclear Magnetic Resonance (13C-NMR), Field Emission Scanning Electron Microscope (FESEM), particle size analysis and Dynamic Light Scattering (DLS). The effect of stimuli responsive (pH and temperature), hydrolysis, drug loading, in-vitro drug release and cytotoxicity was investigated. The finding found that chitosan-p(MAA-co-NIPAM) hydrogel synthesized using surfactant (Span 80) successfully achieved particle size less than 500 nm. The cationic surface charge of synthesis hydrogel passed the stability requirement to avoid aggregation in blood system above 30 mV at pH 3 to 5 and potentially enhanced cellular internalization drug delivery up to pH 6. The release of Rifampicin drug was controlled by combination of diffusion and swelling as the drug released was prolonged to 72 hours indicating that the hydrogel responded to the pH and temperature environment. High viability cell from cytotoxicity assessment demonstrated that the hydrogels are human/animal friendly biomaterials. Thus, it can be concluded that chitosan-p(MAA-co-NIPAM) hydrogels are feasible as controlled drug delivery carrier.
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Md Rasib, Siti Zalifah
author_facet	Md Rasib, Siti Zalifah
author_sort	Md Rasib, Siti Zalifah
title	Synthesis, Characterization And Properties Of Chitosan-Poly (Methacrylic Acid-Co-N-Isopropylacrylamide) Hydrogel For Drug Delivery
title_short	Synthesis, Characterization And Properties Of Chitosan-Poly (Methacrylic Acid-Co-N-Isopropylacrylamide) Hydrogel For Drug Delivery
title_full	Synthesis, Characterization And Properties Of Chitosan-Poly (Methacrylic Acid-Co-N-Isopropylacrylamide) Hydrogel For Drug Delivery
title_fullStr	Synthesis, Characterization And Properties Of Chitosan-Poly (Methacrylic Acid-Co-N-Isopropylacrylamide) Hydrogel For Drug Delivery
title_full_unstemmed	Synthesis, Characterization And Properties Of Chitosan-Poly (Methacrylic Acid-Co-N-Isopropylacrylamide) Hydrogel For Drug Delivery
title_sort	synthesis, characterization and properties of chitosan-poly (methacrylic acid-co-n-isopropylacrylamide) hydrogel for drug delivery
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Kejuruteraan Bahan dan Sumber Mineral
publishDate	2019
url	http://eprints.usm.my/56156/1/Synthesis%2C%20Characterization%20And%20Properties%20Of%20Chitosan-Poly%20%28Methacrylic%20Acid-Co-N-Isopropylacrylamide%29%20Hydrogel%20For%20Drug%20Delivery_Siti%20Zalifah%20Md%20Rasib.pdf
_version_	1776101140348272640

Synthesis, Characterization And Properties Of Chitosan-Poly (Methacrylic Acid-Co-N-Isopropylacrylamide) Hydrogel For Drug Delivery

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