The outcome of breast cancer based on the expression of c-erbb2 , estrogen receptor and progesterone receptor: kelantan experience 2002-2004
Breast cancer in the most common cancer among Malaysian women. There are many prognostic factors contributing to the disease and the outcome of the patients. Hence, a retrospective study was carried out aiming to observe the outcome of breast cancer patient in terms of overall survival with relat...
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| Main Author: | |
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| Format: | Thesis |
| Language: | English |
| Published: |
2010
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| Subjects: | |
| Online Access: | http://eprints.usm.my/56245/1/DR%20MOHARZUDI%20MOHAMED%20-%20e.pdf |
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| Summary: | Breast cancer in the most common cancer among Malaysian women. There are many
prognostic factors contributing to the disease and the outcome of the patients. Hence, a
retrospective study was carried out aiming to observe the outcome of breast cancer
patient in terms of overall survival with relation to estrogen receptor (ER), progesterone
receptor (PR) and c erbB-2 expression. In addition, patient's age, histological subtype,
tumor grade, tumor size and lymph node involvement were also analyzed against overall
survival, ER, PR and c erbB-2 expression.
115 cases of breast cancer diagnosed in three years, 2002 to 2004, were reviewed. It was
found that ER and PR status were positive in 45.2% and 48.7% respectively while
39.1% showed c erbB-2 overexpression. There was significant association between ER
status with tumour grade, tumour size, and PR status. Significant association was also
found between PR status with tumour grade. There was significant association between c
erbB-2 status with tumour grade and lymph nodes involvement. Univariate analysis
showed shorter overall survival in patients with lymph node positive status, ER
negativity, and c-erbB-2 oncoprotein overexpression. In multivariate prognostic analysis,
c erbB-2 status was the strongest independent prognostic factor and ER status was the
second most significant independent prognostic factor for overall survival. However,
lymph node status was not a significant independent prognostic factor. From these
finding, it was concluded that c erbB-2 and ER status was the strongest prognostic factors
contributing to the outcome of breast cancer patients. |
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