Tualang honey in head and neck cancer patients: effects on cancer related fatigue and quality of life

Introduction:Cancer related fatigue (CRF) is a problem experienced by head and neck cancer patients, especially those who underwent chemoradiation therapy.CRF may persist for years post chemoradiation therapy and significantly impair their quality of life (QOL).Tualang honey is rich in amino acid...

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Main Author:	Ramasamy, Viji
Format:	Thesis
Language:	English
Published:	2018
Subjects:	R Medicine RF Otorhinolaryngology
Online Access:	http://eprints.usm.my/56547/1/Dr.%20Viji%20Ramasamay-24%20pages.pdf
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spelling	my-usm-ep.565472023-08-22T07:11:40Z Tualang honey in head and neck cancer patients: effects on cancer related fatigue and quality of life 2018 Ramasamy, Viji R Medicine RC254-282 Neoplasms. Tumors. Oncology (including Cancer) RF Otorhinolaryngology Introduction:Cancer related fatigue (CRF) is a problem experienced by head and neck cancer patients, especially those who underwent chemoradiation therapy.CRF may persist for years post chemoradiation therapy and significantly impair their quality of life (QOL).Tualang honey is rich in amino acids, vitamins, minerals and enzymes. It is proven to have anti-inflammatory, antioxidant and anti-tumour properties. As CRF is related to inflammatory mediators, the effects of Tualang Honey may improve CRF.The aim of this study is to determine if Tualang honey has a role in improving CRF and quality of life among head and neck cancer patients post chemoradiation. Methodology: In this open labelled randomized clinical trial, 40 participants aged between 18 and 65 with head and neck cancer who completed radiotherapy and/or chemotherapy in Hospital USM, Kelantan Malaysia or Hospital Taiping were recruited and randomized into two groups; experimental group (Tualang honey) or control group (Vitamin C). They were prescribed with either daily oral Tualang honey 20mg or tablet vitamin C 100 mg for 8 weeks.Level of fatigue and quality of life were measured usingFACIT-Fatigue and FACT H&N questionnaires at baseline, 4 weeks and 8 weeks. The white cell countand C-reactive protein level were measured at baseline, 4 weeks and 8 weeks. Results: After four and eight weeks of treatment with Tualang honey or Vitamin C, the fatigue level for study group was better than in the control group, and the differences were statistically significant (p<0.05). Statistically significant improvements were seen on quality of life (p<0.05) for the study group at week 8, however, no significant improvements were seen in white cell count and C-reactive protein level between control and study group. Conclusion: Our study provided support for the use of Tualang honey to improve CRF and QOL. The positive results of this study warrant further studies in this field. 2018 Thesis http://eprints.usm.my/56547/ http://eprints.usm.my/56547/1/Dr.%20Viji%20Ramasamay-24%20pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	R Medicine R Medicine RF Otorhinolaryngology
spellingShingle	R Medicine R Medicine RF Otorhinolaryngology Ramasamy, Viji Tualang honey in head and neck cancer patients: effects on cancer related fatigue and quality of life
description	Introduction:Cancer related fatigue (CRF) is a problem experienced by head and neck cancer patients, especially those who underwent chemoradiation therapy.CRF may persist for years post chemoradiation therapy and significantly impair their quality of life (QOL).Tualang honey is rich in amino acids, vitamins, minerals and enzymes. It is proven to have anti-inflammatory, antioxidant and anti-tumour properties. As CRF is related to inflammatory mediators, the effects of Tualang Honey may improve CRF.The aim of this study is to determine if Tualang honey has a role in improving CRF and quality of life among head and neck cancer patients post chemoradiation. Methodology: In this open labelled randomized clinical trial, 40 participants aged between 18 and 65 with head and neck cancer who completed radiotherapy and/or chemotherapy in Hospital USM, Kelantan Malaysia or Hospital Taiping were recruited and randomized into two groups; experimental group (Tualang honey) or control group (Vitamin C). They were prescribed with either daily oral Tualang honey 20mg or tablet vitamin C 100 mg for 8 weeks.Level of fatigue and quality of life were measured usingFACIT-Fatigue and FACT H&N questionnaires at baseline, 4 weeks and 8 weeks. The white cell countand C-reactive protein level were measured at baseline, 4 weeks and 8 weeks. Results: After four and eight weeks of treatment with Tualang honey or Vitamin C, the fatigue level for study group was better than in the control group, and the differences were statistically significant (p<0.05). Statistically significant improvements were seen on quality of life (p<0.05) for the study group at week 8, however, no significant improvements were seen in white cell count and C-reactive protein level between control and study group. Conclusion: Our study provided support for the use of Tualang honey to improve CRF and QOL. The positive results of this study warrant further studies in this field.
format	Thesis
qualification_level	Master's degree
author	Ramasamy, Viji
author_facet	Ramasamy, Viji
author_sort	Ramasamy, Viji
title	Tualang honey in head and neck cancer patients: effects on cancer related fatigue and quality of life
title_short	Tualang honey in head and neck cancer patients: effects on cancer related fatigue and quality of life
title_full	Tualang honey in head and neck cancer patients: effects on cancer related fatigue and quality of life
title_fullStr	Tualang honey in head and neck cancer patients: effects on cancer related fatigue and quality of life
title_full_unstemmed	Tualang honey in head and neck cancer patients: effects on cancer related fatigue and quality of life
title_sort	tualang honey in head and neck cancer patients: effects on cancer related fatigue and quality of life
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2018
url	http://eprints.usm.my/56547/1/Dr.%20Viji%20Ramasamay-24%20pages.pdf
_version_	1776101165438599168

Tualang honey in head and neck cancer patients: effects on cancer related fatigue and quality of life

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