Evaluation of current bacteriological profile and antibiotic sensitivity pattern in Chronic Suppurative Otitis Media (CSOM)

To determine the current bacteriological profile of CSOM, their antimicrobial sensitivity and resistance pattern towards local antibiotic used and the most sensitive antibiotic against isolated bacteria causing CSOM. This was a cross-sectional study involving a total of 91 ear swabs obtained from pa...

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Main Author:	Draman, Wan Nur Anis Wan
Format:	Thesis
Language:	English
Published:	2020
Subjects:	R Medicine (General) RF Otorhinolaryngology
Online Access:	http://eprints.usm.my/56973/1/Wan%20Nur%20Anis%20-%20e%2024.pdf
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id	my-usm-ep.56973
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spelling	my-usm-ep.569732023-02-16T00:34:53Z Evaluation of current bacteriological profile and antibiotic sensitivity pattern in Chronic Suppurative Otitis Media (CSOM) 2020 Draman, Wan Nur Anis Wan R Medicine (General) RF Otorhinolaryngology To determine the current bacteriological profile of CSOM, their antimicrobial sensitivity and resistance pattern towards local antibiotic used and the most sensitive antibiotic against isolated bacteria causing CSOM. This was a cross-sectional study involving a total of 91 ear swabs obtained from patients clinically diagnosed of active CSOM. These swabs were cultured for microbial identification done according to the standard protocol. Microbiological laboratory diagnostic and antibiotic susceptibility testing was performed using Modified Kirby-Bauer’s disc diffusion method. The diameter of inhibitory zone interpreted based on CLSI 2017. Microbial growth was seen in 85 (93.4%) samples while 6 (6.6%) of the samples had no growth. Out of total growth, 63(69.2%) were monomicrobial, 13(14.3%) were polymicrobial and 9 (9.9%) were mixed growth. The most common bacteria isolated was Pseudomonas aeruginosa (32.6%) followed by Staphylococcus aureus(16.9%) and Klebsiellaspp(5.6%). Pseudomonas aeruginosashowed highest sensitivity towards ceftazidime, meropenem and piperacillin-tazobactam. Staphylococcus aureusshowed highest sensitivity to rifampin, cefoxitin and fusidic acid. The commonest microorganism isolated in CSOM was aerobes which were Pseudomonas aeruginosa and Staphylococcus aureus. There is a difference in their antibiotic sensitivity and resistance pattern. This knowledge is important to guide a rational antibiotic use for an effective treatment of CSOM. 2020 Thesis http://eprints.usm.my/56973/ http://eprints.usm.my/56973/1/Wan%20Nur%20Anis%20-%20e%2024.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	R Medicine (General) RF Otorhinolaryngology
spellingShingle	R Medicine (General) RF Otorhinolaryngology Draman, Wan Nur Anis Wan Evaluation of current bacteriological profile and antibiotic sensitivity pattern in Chronic Suppurative Otitis Media (CSOM)
description	To determine the current bacteriological profile of CSOM, their antimicrobial sensitivity and resistance pattern towards local antibiotic used and the most sensitive antibiotic against isolated bacteria causing CSOM. This was a cross-sectional study involving a total of 91 ear swabs obtained from patients clinically diagnosed of active CSOM. These swabs were cultured for microbial identification done according to the standard protocol. Microbiological laboratory diagnostic and antibiotic susceptibility testing was performed using Modified Kirby-Bauer’s disc diffusion method. The diameter of inhibitory zone interpreted based on CLSI 2017. Microbial growth was seen in 85 (93.4%) samples while 6 (6.6%) of the samples had no growth. Out of total growth, 63(69.2%) were monomicrobial, 13(14.3%) were polymicrobial and 9 (9.9%) were mixed growth. The most common bacteria isolated was Pseudomonas aeruginosa (32.6%) followed by Staphylococcus aureus(16.9%) and Klebsiellaspp(5.6%). Pseudomonas aeruginosashowed highest sensitivity towards ceftazidime, meropenem and piperacillin-tazobactam. Staphylococcus aureusshowed highest sensitivity to rifampin, cefoxitin and fusidic acid. The commonest microorganism isolated in CSOM was aerobes which were Pseudomonas aeruginosa and Staphylococcus aureus. There is a difference in their antibiotic sensitivity and resistance pattern. This knowledge is important to guide a rational antibiotic use for an effective treatment of CSOM.
format	Thesis
qualification_level	Master's degree
author	Draman, Wan Nur Anis Wan
author_facet	Draman, Wan Nur Anis Wan
author_sort	Draman, Wan Nur Anis Wan
title	Evaluation of current bacteriological profile and antibiotic sensitivity pattern in Chronic Suppurative Otitis Media (CSOM)
title_short	Evaluation of current bacteriological profile and antibiotic sensitivity pattern in Chronic Suppurative Otitis Media (CSOM)
title_full	Evaluation of current bacteriological profile and antibiotic sensitivity pattern in Chronic Suppurative Otitis Media (CSOM)
title_fullStr	Evaluation of current bacteriological profile and antibiotic sensitivity pattern in Chronic Suppurative Otitis Media (CSOM)
title_full_unstemmed	Evaluation of current bacteriological profile and antibiotic sensitivity pattern in Chronic Suppurative Otitis Media (CSOM)
title_sort	evaluation of current bacteriological profile and antibiotic sensitivity pattern in chronic suppurative otitis media (csom)
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2020
url	http://eprints.usm.my/56973/1/Wan%20Nur%20Anis%20-%20e%2024.pdf
_version_	1776101185093107712

Evaluation of current bacteriological profile and antibiotic sensitivity pattern in Chronic Suppurative Otitis Media (CSOM)

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