Differential tractography pipelines study in asymptomatic individuals with cerebral small vessel disease

Introduction: Cerebral small vessel disease (CSVD) is frequently discovered as an asymptomatic (‘silent’) finding during magnetic resonance imaging (MRI) brain scanning. Diffusion-based MRI, such as diffusion tensor imaging (DTI), is an emerging neuroimaging technique to detect and evaluate the C...

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Main Author:	Safri, Amanina Ahmad
Format:	Thesis
Language:	English
Published:	2022
Subjects:	R Medicine RC Internal medicine
Online Access:	http://eprints.usm.my/57127/1/AMANINA%20AHMAD%20SAFRIl-24%20pages.pdf
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spelling	my-usm-ep.571272023-03-01T08:41:59Z Differential tractography pipelines study in asymptomatic individuals with cerebral small vessel disease 2022-02 Safri, Amanina Ahmad R Medicine RC Internal medicine Introduction: Cerebral small vessel disease (CSVD) is frequently discovered as an asymptomatic (‘silent’) finding during magnetic resonance imaging (MRI) brain scanning. Diffusion-based MRI, such as diffusion tensor imaging (DTI), is an emerging neuroimaging technique to detect and evaluate the CSVD manifestations, such as white matter hyperintensities (WMHs). DTI has been used progressively, but there is no gold standard for optimising the DTI pipeline processing, especially in the CSVD study. Therefore, to make the best use of DTI, several technical and methodological considerations must be made. Objective: The goal of this study is to establish a series of DTI pipeline processing either in a single or a combination of multiple well-established software packages in order to study their compatibility, reproducibility, and reliability in the assessment of white matter ischaemic integrity in asymptomatic CSVD. Methods: Sixty (n = 60) asymptomatic people (mean age, 39.82 years old ± 11.32) were recruited and had their brains scanned with a 3T MRI scanner. Twenty (n = 20) of the participants had WMHs. Four pipeline processing were established: P1(MedINRIA), P2 (DSI Studio), P3 (DTI Toolkit and TrackVis), and P4 (3Dslicer). Results: Each established DTI pipeline processing profile and user interface differences were discussed, including the programming language used, estimated total processing times, and their strengths and weaknesses. The comparison between each of the DTI pipelines processing was determined to be P2 as the best among the other pipelines processing used in this study based on the highest relative score of user interface differences. P2 also has a good reliability score (α = 0.86). Conclusion: This study established the compatibility, reproducibility, and reliability of established DTI pipelines in the assessment of white matter ischemic integrity in apparently asymptomatic CSVD. It provides a comprehensive analysis that can improve and standardise the identification of WMHs and allow for a more robust white matter integrity assessment. Our findings show that the acceptable reliability score in the established DTI pipelined processing is P2 (DSI Studio), which can serve as an ideal pipeline processing to assess white matter tractography in CSVD. 2022-02 Thesis http://eprints.usm.my/57127/ http://eprints.usm.my/57127/1/AMANINA%20AHMAD%20SAFRIl-24%20pages.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	R Medicine RC Internal medicine
spellingShingle	R Medicine RC Internal medicine Safri, Amanina Ahmad Differential tractography pipelines study in asymptomatic individuals with cerebral small vessel disease
description	Introduction: Cerebral small vessel disease (CSVD) is frequently discovered as an asymptomatic (‘silent’) finding during magnetic resonance imaging (MRI) brain scanning. Diffusion-based MRI, such as diffusion tensor imaging (DTI), is an emerging neuroimaging technique to detect and evaluate the CSVD manifestations, such as white matter hyperintensities (WMHs). DTI has been used progressively, but there is no gold standard for optimising the DTI pipeline processing, especially in the CSVD study. Therefore, to make the best use of DTI, several technical and methodological considerations must be made. Objective: The goal of this study is to establish a series of DTI pipeline processing either in a single or a combination of multiple well-established software packages in order to study their compatibility, reproducibility, and reliability in the assessment of white matter ischaemic integrity in asymptomatic CSVD. Methods: Sixty (n = 60) asymptomatic people (mean age, 39.82 years old ± 11.32) were recruited and had their brains scanned with a 3T MRI scanner. Twenty (n = 20) of the participants had WMHs. Four pipeline processing were established: P1(MedINRIA), P2 (DSI Studio), P3 (DTI Toolkit and TrackVis), and P4 (3Dslicer). Results: Each established DTI pipeline processing profile and user interface differences were discussed, including the programming language used, estimated total processing times, and their strengths and weaknesses. The comparison between each of the DTI pipelines processing was determined to be P2 as the best among the other pipelines processing used in this study based on the highest relative score of user interface differences. P2 also has a good reliability score (α = 0.86). Conclusion: This study established the compatibility, reproducibility, and reliability of established DTI pipelines in the assessment of white matter ischemic integrity in apparently asymptomatic CSVD. It provides a comprehensive analysis that can improve and standardise the identification of WMHs and allow for a more robust white matter integrity assessment. Our findings show that the acceptable reliability score in the established DTI pipelined processing is P2 (DSI Studio), which can serve as an ideal pipeline processing to assess white matter tractography in CSVD.
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Safri, Amanina Ahmad
author_facet	Safri, Amanina Ahmad
author_sort	Safri, Amanina Ahmad
title	Differential tractography pipelines study in asymptomatic individuals with cerebral small vessel disease
title_short	Differential tractography pipelines study in asymptomatic individuals with cerebral small vessel disease
title_full	Differential tractography pipelines study in asymptomatic individuals with cerebral small vessel disease
title_fullStr	Differential tractography pipelines study in asymptomatic individuals with cerebral small vessel disease
title_full_unstemmed	Differential tractography pipelines study in asymptomatic individuals with cerebral small vessel disease
title_sort	differential tractography pipelines study in asymptomatic individuals with cerebral small vessel disease
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2022
url	http://eprints.usm.my/57127/1/AMANINA%20AHMAD%20SAFRIl-24%20pages.pdf
_version_	1776101189918654464

Differential tractography pipelines study in asymptomatic individuals with cerebral small vessel disease

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