A retrospective study on survival analysis and its prognostic factors of prostate cancer patients in Hospital Universiti Sains Malaysia

Background: Prostate cancer is a leading cause of male morbidity and mortality globally and in Malaysia. This study assessed the five-year survival and prognostic factors among prostate cancer patients in Hospital USM, Kelantan. Methodology: We reviewed 150 medical records of patients diagnosed w...

Full description

Saved in:

Bibliographic Details
Main Author:	Lutfi, Ahmad Firdaus Ahmad
Format:	Thesis
Language:	English
Published:	2020
Subjects:	RC254-282 Neoplasms Tumors Oncology (including Cancer)
Online Access:	http://eprints.usm.my/57236/1/DR%20AHMAD%20FIRDAUS%20BIN%20AHMAD%20LUTFI-24%20pages.pdf
Tags:	Add Tag No Tags, Be the first to tag this record!

id	my-usm-ep.57236
record_format	uketd_dc
spelling	my-usm-ep.572362023-03-09T06:46:40Z A retrospective study on survival analysis and its prognostic factors of prostate cancer patients in Hospital Universiti Sains Malaysia 2020 Lutfi, Ahmad Firdaus Ahmad RC254-282 Neoplasms. Tumors. Oncology (including Cancer) Background: Prostate cancer is a leading cause of male morbidity and mortality globally and in Malaysia. This study assessed the five-year survival and prognostic factors among prostate cancer patients in Hospital USM, Kelantan. Methodology: We reviewed 150 medical records of patients diagnosed with prostate cancer, from 2009 to 2014. Survival time was analyzed in relation of patient demographics, Gleason score, ASA classification, ECOG scores, PSA level, family history, cancer staging, cancerrelated hematological parameters, and treatment method. Kaplan-Meier survival curves and Cox proportional hazards models are used for the analysis. Results: The prostate cancer five-year survival rate was 84.5%. Overall Kaplan-Meier survival curve showed good median survival times. Univariate regression analysis revealed significant prognostic factors including age (HR=1.06, 95% CI:1.00, 1.11, p=0.034), ASA 3 classification (HR=3.72, 95% CI:1.38, 10.00, p=0.009), ECOG score 2 (HR=17.98, 95% CI:3.98, 81.1, p<0.001), ECOG 3 (HR=33.94, 95% CI:7.41, 150.0, p<0.001), anemia (HR=9.07, 95% CI:3.33, 24.6, p<0.001), High LDH (HR=5.37, 95% CI:1.80, 15.90, p=0.003), High ALP (HR=8.94, 95% CI:3.31, 24.1, p<0.001), Nodular staging (HR=5.87, 95% CI:1.74, 19.85, p=0.004), Metastasis (HR=3.48, 95% CI:1.28, 9.44, p=0.014), Androgen Deprivation Therapy (HR= 0.29, 95% CI:0.08, 0.99, p=0.05) and Chemotherapy (HR=4.57, 95% CI:1.79, 11.6, p=0.001). Conclusion: The five-year survival rate of HUSM patients treated for prostate cancer was 84.5%. The survival rate reduces significantly due to prognostic factors like age, ASA classification, ECOG score, some hematological parameters, cancer staging and chemotherapy. However, patients received the ADT have a better survival rate, which suggests the main role of prompt initiation of the therapy in improving patient survival. 2020 Thesis http://eprints.usm.my/57236/ http://eprints.usm.my/57236/1/DR%20AHMAD%20FIRDAUS%20BIN%20AHMAD%20LUTFI-24%20pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RC254-282 Neoplasms Tumors Oncology (including Cancer)
spellingShingle	RC254-282 Neoplasms Tumors Oncology (including Cancer) Lutfi, Ahmad Firdaus Ahmad A retrospective study on survival analysis and its prognostic factors of prostate cancer patients in Hospital Universiti Sains Malaysia
description	Background: Prostate cancer is a leading cause of male morbidity and mortality globally and in Malaysia. This study assessed the five-year survival and prognostic factors among prostate cancer patients in Hospital USM, Kelantan. Methodology: We reviewed 150 medical records of patients diagnosed with prostate cancer, from 2009 to 2014. Survival time was analyzed in relation of patient demographics, Gleason score, ASA classification, ECOG scores, PSA level, family history, cancer staging, cancerrelated hematological parameters, and treatment method. Kaplan-Meier survival curves and Cox proportional hazards models are used for the analysis. Results: The prostate cancer five-year survival rate was 84.5%. Overall Kaplan-Meier survival curve showed good median survival times. Univariate regression analysis revealed significant prognostic factors including age (HR=1.06, 95% CI:1.00, 1.11, p=0.034), ASA 3 classification (HR=3.72, 95% CI:1.38, 10.00, p=0.009), ECOG score 2 (HR=17.98, 95% CI:3.98, 81.1, p<0.001), ECOG 3 (HR=33.94, 95% CI:7.41, 150.0, p<0.001), anemia (HR=9.07, 95% CI:3.33, 24.6, p<0.001), High LDH (HR=5.37, 95% CI:1.80, 15.90, p=0.003), High ALP (HR=8.94, 95% CI:3.31, 24.1, p<0.001), Nodular staging (HR=5.87, 95% CI:1.74, 19.85, p=0.004), Metastasis (HR=3.48, 95% CI:1.28, 9.44, p=0.014), Androgen Deprivation Therapy (HR= 0.29, 95% CI:0.08, 0.99, p=0.05) and Chemotherapy (HR=4.57, 95% CI:1.79, 11.6, p=0.001). Conclusion: The five-year survival rate of HUSM patients treated for prostate cancer was 84.5%. The survival rate reduces significantly due to prognostic factors like age, ASA classification, ECOG score, some hematological parameters, cancer staging and chemotherapy. However, patients received the ADT have a better survival rate, which suggests the main role of prompt initiation of the therapy in improving patient survival.
format	Thesis
qualification_level	Master's degree
author	Lutfi, Ahmad Firdaus Ahmad
author_facet	Lutfi, Ahmad Firdaus Ahmad
author_sort	Lutfi, Ahmad Firdaus Ahmad
title	A retrospective study on survival analysis and its prognostic factors of prostate cancer patients in Hospital Universiti Sains Malaysia
title_short	A retrospective study on survival analysis and its prognostic factors of prostate cancer patients in Hospital Universiti Sains Malaysia
title_full	A retrospective study on survival analysis and its prognostic factors of prostate cancer patients in Hospital Universiti Sains Malaysia
title_fullStr	A retrospective study on survival analysis and its prognostic factors of prostate cancer patients in Hospital Universiti Sains Malaysia
title_full_unstemmed	A retrospective study on survival analysis and its prognostic factors of prostate cancer patients in Hospital Universiti Sains Malaysia
title_sort	retrospective study on survival analysis and its prognostic factors of prostate cancer patients in hospital universiti sains malaysia
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2020
url	http://eprints.usm.my/57236/1/DR%20AHMAD%20FIRDAUS%20BIN%20AHMAD%20LUTFI-24%20pages.pdf
_version_	1776101193515270144

A retrospective study on survival analysis and its prognostic factors of prostate cancer patients in Hospital Universiti Sains Malaysia

Similar Items