Neuronal activation in patients with mild and moderate traumatic brain injury during working memory tasks
Background and Objective Cognitive impairment in patients following TBI is a significant cause of morbidity both to patients and their families. Memory impairment is one of the most common complaint patients and their families have as it impairs patients’ daily function. Current neuroimaging mod...
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| Main Author: | |
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| Format: | Thesis |
| Language: | English |
| Published: |
2020
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| Subjects: | |
| Online Access: | http://eprints.usm.my/57316/1/DR%20DIANA%20NOMA%20BINTI%20FITZROL-24%20pages.pdf |
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| Summary: | Background and Objective
Cognitive impairment in patients following TBI is a significant cause of morbidity
both to patients and their families. Memory impairment is one of the most common
complaint patients and their families have as it impairs patients’ daily function. Current
neuroimaging modalities allows us to study the neuronal activation relevant to working
memory in patients.
Methods
Patients who sustained mTBI/ modTBI, between the age of 18 to 65 years old and
managed in Hospital Universiti Sains Malaysia were recruited into the study. These patients
and a control group underwent fMRI scanning where they concurrently performed n-back
tasks of 4 different memory loads. These fMRI scans were performed at 6 to 10 weeks postinjury
and at 6 months post-injury. These cohort of subjects also had neuropsychology
assessments performed at the same two time period as the fMRI.
Results |
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