Assessment of inflammatory markers and periodontal outcomes in CKD patients with periodontitis

Chronic kidney disease (CKD) and periodontitis have an impact on patient’s morbidity and mortality. The prevalence of comorbid CKD and periodontitis is shown to be frequent. Periodontitis increases the inflammatory burden, which has been shown to disrupt renal function by altering serum inflammat...

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Main Author:	Rahman, Nurul Aliya Abdul
Format:	Thesis
Language:	English
Published:	2022
Subjects:	RC870-923 Diseases of the genitourinary system Urology
Online Access:	http://eprints.usm.my/57349/1/NURUL%20ALIYA%20BINTI%20ABDUL%20RAHMAN-FINAL%20THESIS%20P-SGM000420%28R%29%20-24%20pages.pdf
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spelling	my-usm-ep.573492023-11-23T07:03:13Z Assessment of inflammatory markers and periodontal outcomes in CKD patients with periodontitis 2022-06 Rahman, Nurul Aliya Abdul RC870-923 Diseases of the genitourinary system. Urology Chronic kidney disease (CKD) and periodontitis have an impact on patient’s morbidity and mortality. The prevalence of comorbid CKD and periodontitis is shown to be frequent. Periodontitis increases the inflammatory burden, which has been shown to disrupt renal function by altering serum inflammatory levels, and potentially worsening CKD. Pro-inflammatory Interleukin-1 (IL-1) and anti-inflammatory Interleukin-10 (IL-10) have immunomodulatory properties that regulates host immune responses. Little is known about changes in the serum inflammatory markers of IL-1 and IL-10 following the periodontal therapy in CKD patients in our populations. Therefore, this study was aimed to assess and compare the levels of inflammatory markers IL-1 and IL-10 as well as periodontal parameters at baseline and after receiving NSPT. Twenty CKD patients (stage 3 and stage 4) with periodontitis (Group 1), twenty non-CKD patients with periodontitis (Group 2) and twenty healthy patients (Group 3) were selected. The dental parameters such as Periodontal Probing Depth (PPD), Clinical Attachment Loss (CAL), Gingival Bleeding Index (GI) and Plaque Score (PS) were measured in each patient during first visit (baseline) and six weeks later (second visit). Blood sample was collected during each visit and analysed for serum IL-1 and IL-10 concentration using Enzyme-Linked Immunosorbent Assay. Our findings shows that IL-1 and IL-10 levels were found significantly higher (p<0.05) in CKD patients with periodontitis (Group 1) as compared to non-CKD patients with periodontitis (Group 2) and healthy subjects (Group 3). When compared to other groups, the levels of dental parameters (PPD, PS and GBI in Group 1 were significantly higher (p<0.05). Following NSPT, there was significant reduction (p<0.05) in inflammatory markers and clinical periodontal parameters in Group 1 and Group 2. This study demonstrates that patients with CKD and periodontitis had a more severe systemic inflammatory response and poorer periodontal status than non-CKD. NSPT shown improvement in both inflammatory markers and dental parameters as well as delay the progression of CKD. IL-1 and IL-10 is a promising inflammatory marker to assess CKD progression. Therefore, multicentre and larger sample size studies are needed in the future. 2022-06 Thesis http://eprints.usm.my/57349/ http://eprints.usm.my/57349/1/NURUL%20ALIYA%20BINTI%20ABDUL%20RAHMAN-FINAL%20THESIS%20P-SGM000420%28R%29%20-24%20pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Pergigian
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RC870-923 Diseases of the genitourinary system Urology
spellingShingle	RC870-923 Diseases of the genitourinary system Urology Rahman, Nurul Aliya Abdul Assessment of inflammatory markers and periodontal outcomes in CKD patients with periodontitis
description	Chronic kidney disease (CKD) and periodontitis have an impact on patient’s morbidity and mortality. The prevalence of comorbid CKD and periodontitis is shown to be frequent. Periodontitis increases the inflammatory burden, which has been shown to disrupt renal function by altering serum inflammatory levels, and potentially worsening CKD. Pro-inflammatory Interleukin-1 (IL-1) and anti-inflammatory Interleukin-10 (IL-10) have immunomodulatory properties that regulates host immune responses. Little is known about changes in the serum inflammatory markers of IL-1 and IL-10 following the periodontal therapy in CKD patients in our populations. Therefore, this study was aimed to assess and compare the levels of inflammatory markers IL-1 and IL-10 as well as periodontal parameters at baseline and after receiving NSPT. Twenty CKD patients (stage 3 and stage 4) with periodontitis (Group 1), twenty non-CKD patients with periodontitis (Group 2) and twenty healthy patients (Group 3) were selected. The dental parameters such as Periodontal Probing Depth (PPD), Clinical Attachment Loss (CAL), Gingival Bleeding Index (GI) and Plaque Score (PS) were measured in each patient during first visit (baseline) and six weeks later (second visit). Blood sample was collected during each visit and analysed for serum IL-1 and IL-10 concentration using Enzyme-Linked Immunosorbent Assay. Our findings shows that IL-1 and IL-10 levels were found significantly higher (p<0.05) in CKD patients with periodontitis (Group 1) as compared to non-CKD patients with periodontitis (Group 2) and healthy subjects (Group 3). When compared to other groups, the levels of dental parameters (PPD, PS and GBI in Group 1 were significantly higher (p<0.05). Following NSPT, there was significant reduction (p<0.05) in inflammatory markers and clinical periodontal parameters in Group 1 and Group 2. This study demonstrates that patients with CKD and periodontitis had a more severe systemic inflammatory response and poorer periodontal status than non-CKD. NSPT shown improvement in both inflammatory markers and dental parameters as well as delay the progression of CKD. IL-1 and IL-10 is a promising inflammatory marker to assess CKD progression. Therefore, multicentre and larger sample size studies are needed in the future.
format	Thesis
qualification_level	Master's degree
author	Rahman, Nurul Aliya Abdul
author_facet	Rahman, Nurul Aliya Abdul
author_sort	Rahman, Nurul Aliya Abdul
title	Assessment of inflammatory markers and periodontal outcomes in CKD patients with periodontitis
title_short	Assessment of inflammatory markers and periodontal outcomes in CKD patients with periodontitis
title_full	Assessment of inflammatory markers and periodontal outcomes in CKD patients with periodontitis
title_fullStr	Assessment of inflammatory markers and periodontal outcomes in CKD patients with periodontitis
title_full_unstemmed	Assessment of inflammatory markers and periodontal outcomes in CKD patients with periodontitis
title_sort	assessment of inflammatory markers and periodontal outcomes in ckd patients with periodontitis
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Pergigian
publishDate	2022
url	http://eprints.usm.my/57349/1/NURUL%20ALIYA%20BINTI%20ABDUL%20RAHMAN-FINAL%20THESIS%20P-SGM000420%28R%29%20-24%20pages.pdf
_version_	1794024023109140480

Assessment of inflammatory markers and periodontal outcomes in CKD patients with periodontitis

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