The evaluation of program death 1 and PD-1 ligand expressions in histological subtypes of primary extranodal non hodgkin lymphoma

Introduction: Emergence of Programmed death 1 (PD-1) and its ligands, PD-L1 immunotherapy provide new insight in the treatment modality of malignancies. The responsiveness of the patients are associated with the expressions of the PD-L1 and PD-1 protein. We aimed to evaluate the expression of PD-...

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Main Author:	Mohaidin, Farhana Mohammad
Format:	Thesis
Language:	English
Published:	2021
Subjects:	RC Internal medicine
Online Access:	http://eprints.usm.my/58572/1/FARHANA%20MOHAMMAD%20MOHAIDIN-24%20pages.pdf
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spelling	my-usm-ep.585722023-05-18T02:28:28Z The evaluation of program death 1 and PD-1 ligand expressions in histological subtypes of primary extranodal non hodgkin lymphoma 2021 Mohaidin, Farhana Mohammad RC Internal medicine Introduction: Emergence of Programmed death 1 (PD-1) and its ligands, PD-L1 immunotherapy provide new insight in the treatment modality of malignancies. The responsiveness of the patients are associated with the expressions of the PD-L1 and PD-1 protein. We aimed to evaluate the expression of PD-1 in the tumour microenvironment and PD-L1 in the tumour cells with histological subtypes of primary extranodal non-Hodgkin lymphoma (peNHL). Methodology: A retrospective cross-sectional study using 87 archived formalin fixed paraffin-embedded tissue blocks of patients diagnosed with peNHL. Samples were stained for PD-1 and PD-L1 by immunohistochemistry method and the proteins expressions were evaluated microscopically. The association between expression of the PD-1 and PD-L1 with subtypes of peNHL were statistically analysed. Results: Majority of the cases are negative expression of PD-L1 in the tumour cells (46, 52.9%), however majority are positive for PD-1 expression in the tumour microenvironment (57, 65.5%). Significant associations were found between PD-1 and PD-L1 expression with subtypes of peNHL (p<0.05) and higher expression was found in DLBCL. Conclusion: Our study, the first in Malaysia to explore expression of PD-1 and PD-L1 in peNHL, demonstrates significant association of PD-1 and PD-L1 expressions with subtypes of peNHL which may impact treatment of these patients in the future. 2021 Thesis http://eprints.usm.my/58572/ http://eprints.usm.my/58572/1/FARHANA%20MOHAMMAD%20MOHAIDIN-24%20pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RC Internal medicine
spellingShingle	RC Internal medicine Mohaidin, Farhana Mohammad The evaluation of program death 1 and PD-1 ligand expressions in histological subtypes of primary extranodal non hodgkin lymphoma
description	Introduction: Emergence of Programmed death 1 (PD-1) and its ligands, PD-L1 immunotherapy provide new insight in the treatment modality of malignancies. The responsiveness of the patients are associated with the expressions of the PD-L1 and PD-1 protein. We aimed to evaluate the expression of PD-1 in the tumour microenvironment and PD-L1 in the tumour cells with histological subtypes of primary extranodal non-Hodgkin lymphoma (peNHL). Methodology: A retrospective cross-sectional study using 87 archived formalin fixed paraffin-embedded tissue blocks of patients diagnosed with peNHL. Samples were stained for PD-1 and PD-L1 by immunohistochemistry method and the proteins expressions were evaluated microscopically. The association between expression of the PD-1 and PD-L1 with subtypes of peNHL were statistically analysed. Results: Majority of the cases are negative expression of PD-L1 in the tumour cells (46, 52.9%), however majority are positive for PD-1 expression in the tumour microenvironment (57, 65.5%). Significant associations were found between PD-1 and PD-L1 expression with subtypes of peNHL (p<0.05) and higher expression was found in DLBCL. Conclusion: Our study, the first in Malaysia to explore expression of PD-1 and PD-L1 in peNHL, demonstrates significant association of PD-1 and PD-L1 expressions with subtypes of peNHL which may impact treatment of these patients in the future.
format	Thesis
qualification_level	Master's degree
author	Mohaidin, Farhana Mohammad
author_facet	Mohaidin, Farhana Mohammad
author_sort	Mohaidin, Farhana Mohammad
title	The evaluation of program death 1 and PD-1 ligand expressions in histological subtypes of primary extranodal non hodgkin lymphoma
title_short	The evaluation of program death 1 and PD-1 ligand expressions in histological subtypes of primary extranodal non hodgkin lymphoma
title_full	The evaluation of program death 1 and PD-1 ligand expressions in histological subtypes of primary extranodal non hodgkin lymphoma
title_fullStr	The evaluation of program death 1 and PD-1 ligand expressions in histological subtypes of primary extranodal non hodgkin lymphoma
title_full_unstemmed	The evaluation of program death 1 and PD-1 ligand expressions in histological subtypes of primary extranodal non hodgkin lymphoma
title_sort	evaluation of program death 1 and pd-1 ligand expressions in histological subtypes of primary extranodal non hodgkin lymphoma
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2021
url	http://eprints.usm.my/58572/1/FARHANA%20MOHAMMAD%20MOHAIDIN-24%20pages.pdf
_version_	1776101227584552960

The evaluation of program death 1 and PD-1 ligand expressions in histological subtypes of primary extranodal non hodgkin lymphoma

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