Effects Of Combined L-Carnitine Supplementation and Moderate-Intensity Exercise on Body Composition, Metabolic And Oxidative Stress Markers, Bone Parameters and Muscular Performance in Overweight and Obese Individuals

Effects Of Combined L-Carnitine Supplementation and Moderate-Intensity Exercise on Body Composition, Metabolic And Oxidative Stress Markers, Bone Parameters and Muscular Performance in Overweight and Obese Individuals

The effects of 12 weeks of combined L-carnitine supplementation and moderateintensity exercise on body composition, metabolic and oxidative stress markers, bone parameters and muscular performance in overweight and obese individuals were determined. Sixty-eight participants aged 29.03 ± 6.02 year...

Full description

Saved in:
Bibliographic Details
Main Author: Samsudin, Norsuriani
Format: Thesis
Language:English
Published: 2023
Subjects:
QP Physiology
QP501-801 Animal biochemistry
Online Access:http://eprints.usm.my/58814/1/09-NORSURIANI%20BINTI%20SAMSUDIN-FINAL%20THESIS%20P-SKD001320%28R%29%20-24%20pages.pdf
Tags: Add Tag
No Tags, Be the first to tag this record!
id my-usm-ep.58814
record_format uketd_dc
spelling my-usm-ep.588142023-07-06T01:13:01Z Effects Of Combined L-Carnitine Supplementation and Moderate-Intensity Exercise on Body Composition, Metabolic And Oxidative Stress Markers, Bone Parameters and Muscular Performance in Overweight and Obese Individuals 2023-01 Samsudin, Norsuriani QP Physiology QP501-801 Animal biochemistry The effects of 12 weeks of combined L-carnitine supplementation and moderateintensity exercise on body composition, metabolic and oxidative stress markers, bone parameters and muscular performance in overweight and obese individuals were determined. Sixty-eight participants aged 29.03 ± 6.02 years old were divided into control (C), L-carnitine supplement (S), exercise (E), combined L-carnitine and exercise (SE) groups. Participants in supplement groups consumed 1 tablet of 1000mg L-carnitine daily. Participants in exercise groups performed 30 minutes of brisk walking (50% HRmax) and continued with 10 to 20 minutes of interval training per session, 3 times per week. Mean energy intake was higher than their mean energy expenditure. The percentages of carbohydrate, protein and fat intakes were significantly higher than recommended nutrient intake (RNI) values. After 12 weeks of intervention, there were significant reduction (p< 0.05) in body weight, body mass index, fat percentage, fat mass, and increase (p< 0.05) in fat free mass (FFM) in S, E and SE groups. Regarding metabolic markers, waist to hip ratio, blood glucose, triglycerides, low-density lipoprotein, and total cholesterol, SE group expressed the highest reduction (p< 0.05) compared to C group. All groups showed enhancement (p< 0.05) in both radial and tibial speed of sound of dominant and non-dominant arms and legs within the groups except for C group. There were significant greater (p< 0.05) extension and flexion peak torque and average power in both legs and arms at 60o.s-1 and 300o.s-1 in S, E and SE groups compared to C group and SE group was expressed the greatest value. In comparison with C groups, all groups showed greater values of serum ALP (p< 0.05) and total calcium (p < 0.05), but significantly lower value of serum 1CTP (p< 0.05). Malondialdehyde (MDA) and reactive oxygen species (ROS) values significantly reduced in all groups (p< 0.05) except for C group. Meanwhile for antioxidant markers, serum catalase (CAT) and superoxide dismutase (SOD), all groups displayed greater increment (p< 0.05) compared to C group, and SE group demonstrated the highest increment. In terms of interleukin-6, S and SE groups also showed higher decrement (p< 0.05), meanwhile E group showed higher increment compared to C group, and the greatest decrement (p< 0.05) was observed in SE group. The toxicity test explained that L-carnitine supplement are safe to be consumed in 12 weeks. Generally, combinations of L-carnitine supplement with brisk walking and interval exercise for 12 weeks elicit beneficial effects to improve overall parameters in overweight and obese individuals. 2023-01 Thesis http://eprints.usm.my/58814/ http://eprints.usm.my/58814/1/09-NORSURIANI%20BINTI%20SAMSUDIN-FINAL%20THESIS%20P-SKD001320%28R%29%20-24%20pages.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Pusat Pengajian Sains Kesihatan
institution Universiti Sains Malaysia
collection USM Institutional Repository
language English
topic QP Physiology
QP501-801 Animal biochemistry
spellingShingle QP Physiology
QP501-801 Animal biochemistry
Samsudin, Norsuriani
Effects Of Combined L-Carnitine Supplementation and Moderate-Intensity Exercise on Body Composition, Metabolic And Oxidative Stress Markers, Bone Parameters and Muscular Performance in Overweight and Obese Individuals
description The effects of 12 weeks of combined L-carnitine supplementation and moderateintensity exercise on body composition, metabolic and oxidative stress markers, bone parameters and muscular performance in overweight and obese individuals were determined. Sixty-eight participants aged 29.03 ± 6.02 years old were divided into control (C), L-carnitine supplement (S), exercise (E), combined L-carnitine and exercise (SE) groups. Participants in supplement groups consumed 1 tablet of 1000mg L-carnitine daily. Participants in exercise groups performed 30 minutes of brisk walking (50% HRmax) and continued with 10 to 20 minutes of interval training per session, 3 times per week. Mean energy intake was higher than their mean energy expenditure. The percentages of carbohydrate, protein and fat intakes were significantly higher than recommended nutrient intake (RNI) values. After 12 weeks of intervention, there were significant reduction (p< 0.05) in body weight, body mass index, fat percentage, fat mass, and increase (p< 0.05) in fat free mass (FFM) in S, E and SE groups. Regarding metabolic markers, waist to hip ratio, blood glucose, triglycerides, low-density lipoprotein, and total cholesterol, SE group expressed the highest reduction (p< 0.05) compared to C group. All groups showed enhancement (p< 0.05) in both radial and tibial speed of sound of dominant and non-dominant arms and legs within the groups except for C group. There were significant greater (p< 0.05) extension and flexion peak torque and average power in both legs and arms at 60o.s-1 and 300o.s-1 in S, E and SE groups compared to C group and SE group was expressed the greatest value. In comparison with C groups, all groups showed greater values of serum ALP (p< 0.05) and total calcium (p < 0.05), but significantly lower value of serum 1CTP (p< 0.05). Malondialdehyde (MDA) and reactive oxygen species (ROS) values significantly reduced in all groups (p< 0.05) except for C group. Meanwhile for antioxidant markers, serum catalase (CAT) and superoxide dismutase (SOD), all groups displayed greater increment (p< 0.05) compared to C group, and SE group demonstrated the highest increment. In terms of interleukin-6, S and SE groups also showed higher decrement (p< 0.05), meanwhile E group showed higher increment compared to C group, and the greatest decrement (p< 0.05) was observed in SE group. The toxicity test explained that L-carnitine supplement are safe to be consumed in 12 weeks. Generally, combinations of L-carnitine supplement with brisk walking and interval exercise for 12 weeks elicit beneficial effects to improve overall parameters in overweight and obese individuals.
format Thesis
qualification_name Doctor of Philosophy (PhD.)
qualification_level Doctorate
author Samsudin, Norsuriani
author_facet Samsudin, Norsuriani
author_sort Samsudin, Norsuriani
title Effects Of Combined L-Carnitine Supplementation and Moderate-Intensity Exercise on Body Composition, Metabolic And Oxidative Stress Markers, Bone Parameters and Muscular Performance in Overweight and Obese Individuals
title_short Effects Of Combined L-Carnitine Supplementation and Moderate-Intensity Exercise on Body Composition, Metabolic And Oxidative Stress Markers, Bone Parameters and Muscular Performance in Overweight and Obese Individuals
title_full Effects Of Combined L-Carnitine Supplementation and Moderate-Intensity Exercise on Body Composition, Metabolic And Oxidative Stress Markers, Bone Parameters and Muscular Performance in Overweight and Obese Individuals
title_fullStr Effects Of Combined L-Carnitine Supplementation and Moderate-Intensity Exercise on Body Composition, Metabolic And Oxidative Stress Markers, Bone Parameters and Muscular Performance in Overweight and Obese Individuals
title_full_unstemmed Effects Of Combined L-Carnitine Supplementation and Moderate-Intensity Exercise on Body Composition, Metabolic And Oxidative Stress Markers, Bone Parameters and Muscular Performance in Overweight and Obese Individuals
title_sort effects of combined l-carnitine supplementation and moderate-intensity exercise on body composition, metabolic and oxidative stress markers, bone parameters and muscular performance in overweight and obese individuals
granting_institution Universiti Sains Malaysia
granting_department Pusat Pengajian Sains Kesihatan
publishDate 2023
url http://eprints.usm.my/58814/1/09-NORSURIANI%20BINTI%20SAMSUDIN-FINAL%20THESIS%20P-SKD001320%28R%29%20-24%20pages.pdf
_version_ 1776101233097965568

Similar Items