Neonatal Outcomes of Pregnancies Complicated By Maternal Hyperthyroidism

Objective: We aim to study the proportion of infants born to maternal hyperthyroidism, their clinical, hormonal status, median time and factors affecting time for serum free T4 (fT4) and TSH normalization. Methodology: A cross-sectional study recruited 186 inborns admitted to Neonatal Intensive...

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Main Author:	Mamat @ Abdullah, Adlina Awanis
Format:	Thesis
Language:	English
Published:	2021
Subjects:	RJ251-325 Newborn infants Including physiology care treatment diseases
Online Access:	http://eprints.usm.my/58824/1/Adlina%20Awanis-%2024%20pages.pdf
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spelling	my-usm-ep.588242023-07-06T06:36:31Z Neonatal Outcomes of Pregnancies Complicated By Maternal Hyperthyroidism 2021 Mamat @ Abdullah, Adlina Awanis RJ251-325 Newborn infants Including physiology, care, treatment, diseases Objective: We aim to study the proportion of infants born to maternal hyperthyroidism, their clinical, hormonal status, median time and factors affecting time for serum free T4 (fT4) and TSH normalization. Methodology: A cross-sectional study recruited 186 inborns admitted to Neonatal Intensive Care Unit (NICU), Hospital Universiti Sains Malaysia (Hospital USM) from January 2013 until December 2018. We analyzed newborn’s demographic and clinical characteristic, maternal treatment, maternal thyroid autoantibodies level and thyroid function. Finally, we analyzed the newborn’s thyroid function and thyroid autoantibodies. Abnormal thyroid function was categorised according to European Society of Paediatric Endocrinology (ESPE) for newborn. Kaplan Meier analysis were used to determine median time of fT4, TSH normalization and multiple logistic regression model were used to examine the associations between risk variables affecting fT4, TSH normalization in these newborns. Results: The proportion of newborns with maternal hyperthyroidism were 0.92% (186/ 20198). Only 170 newborns were included in the study. Out of 102 (60%) newborns with an abnormal TFT, 7 (4.1%) developed overt hyperthyroidism with 4 (2.4%) were complicated by thyroid storm. Only 54 out 170 mothers (31.7%) were checked for presence of thyroid autoantibodies. The overall median time for TFT normalization was 30 days (95% CI): (27.1, 32.8). Cox Proportional Hazard revealed normal TFT on day 3-5, crude HR: 95% CI: 4.918 (2.11, 11.44) and day 15: 3.496 (1.61, 7.58) were significant variables affecting time of normalization. Conclusion: The proportion of newborns with maternal hyperthyroidism were 0.92%. Most infants with maternal hyperthyroidism had a self-limiting course with median TFT normalization time of 30 days. Abnormal TFT at day 3-5, abnormal TFT at day 15, maternal received thyroid treatment and maternal presence of thyroid autoantibodies were significant predictors affecting fT4, TSH normalization for these newborns. 2021 Thesis http://eprints.usm.my/58824/ http://eprints.usm.my/58824/1/Adlina%20Awanis-%2024%20pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RJ251-325 Newborn infants Including physiology care treatment diseases
spellingShingle	RJ251-325 Newborn infants Including physiology care treatment diseases Mamat @ Abdullah, Adlina Awanis Neonatal Outcomes of Pregnancies Complicated By Maternal Hyperthyroidism
description	Objective: We aim to study the proportion of infants born to maternal hyperthyroidism, their clinical, hormonal status, median time and factors affecting time for serum free T4 (fT4) and TSH normalization. Methodology: A cross-sectional study recruited 186 inborns admitted to Neonatal Intensive Care Unit (NICU), Hospital Universiti Sains Malaysia (Hospital USM) from January 2013 until December 2018. We analyzed newborn’s demographic and clinical characteristic, maternal treatment, maternal thyroid autoantibodies level and thyroid function. Finally, we analyzed the newborn’s thyroid function and thyroid autoantibodies. Abnormal thyroid function was categorised according to European Society of Paediatric Endocrinology (ESPE) for newborn. Kaplan Meier analysis were used to determine median time of fT4, TSH normalization and multiple logistic regression model were used to examine the associations between risk variables affecting fT4, TSH normalization in these newborns. Results: The proportion of newborns with maternal hyperthyroidism were 0.92% (186/ 20198). Only 170 newborns were included in the study. Out of 102 (60%) newborns with an abnormal TFT, 7 (4.1%) developed overt hyperthyroidism with 4 (2.4%) were complicated by thyroid storm. Only 54 out 170 mothers (31.7%) were checked for presence of thyroid autoantibodies. The overall median time for TFT normalization was 30 days (95% CI): (27.1, 32.8). Cox Proportional Hazard revealed normal TFT on day 3-5, crude HR: 95% CI: 4.918 (2.11, 11.44) and day 15: 3.496 (1.61, 7.58) were significant variables affecting time of normalization. Conclusion: The proportion of newborns with maternal hyperthyroidism were 0.92%. Most infants with maternal hyperthyroidism had a self-limiting course with median TFT normalization time of 30 days. Abnormal TFT at day 3-5, abnormal TFT at day 15, maternal received thyroid treatment and maternal presence of thyroid autoantibodies were significant predictors affecting fT4, TSH normalization for these newborns.
format	Thesis
qualification_level	Master's degree
author	Mamat @ Abdullah, Adlina Awanis
author_facet	Mamat @ Abdullah, Adlina Awanis
author_sort	Mamat @ Abdullah, Adlina Awanis
title	Neonatal Outcomes of Pregnancies Complicated By Maternal Hyperthyroidism
title_short	Neonatal Outcomes of Pregnancies Complicated By Maternal Hyperthyroidism
title_full	Neonatal Outcomes of Pregnancies Complicated By Maternal Hyperthyroidism
title_fullStr	Neonatal Outcomes of Pregnancies Complicated By Maternal Hyperthyroidism
title_full_unstemmed	Neonatal Outcomes of Pregnancies Complicated By Maternal Hyperthyroidism
title_sort	neonatal outcomes of pregnancies complicated by maternal hyperthyroidism
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2021
url	http://eprints.usm.my/58824/1/Adlina%20Awanis-%2024%20pages.pdf
_version_	1776101235256983552

Neonatal Outcomes of Pregnancies Complicated By Maternal Hyperthyroidism

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