Evaluation of immunophenotypic expressions of plasma cells in plasma cell myeloma patients and its association with prognostic factors and clinical stages

Introduction: Neoplastic plasma cell expresses aberrant markers which differ from normal plasma cell was postulated to carry prognostic significance. This study aimed to determine the proportion of immunophenotypic expression of plasma cells in plasma cell myeloma patients at diagnosis and to stu...

Full description

Saved in:

Bibliographic Details
Main Author:	Chi, Ling Pei
Format:	Thesis
Language:	English
Published:	2021
Subjects:	RC31-1245 Internal medicine
Online Access:	http://eprints.usm.my/58840/1/Ling%20Pei%20Chei-24%20pages.pdf
Tags:	Add Tag No Tags, Be the first to tag this record!

id	my-usm-ep.58840
record_format	uketd_dc
spelling	my-usm-ep.588402023-07-06T05:14:46Z Evaluation of immunophenotypic expressions of plasma cells in plasma cell myeloma patients and its association with prognostic factors and clinical stages 2021 Chi, Ling Pei RC31-1245 Internal medicine Introduction: Neoplastic plasma cell expresses aberrant markers which differ from normal plasma cell was postulated to carry prognostic significance. This study aimed to determine the proportion of immunophenotypic expression of plasma cells in plasma cell myeloma patients at diagnosis and to study the association between these markers with clinical and laboratory parameters. Methods: A retrospective study was carried out from June 2016 till June 2019 by collecting the flow cytometry results (CD38/CD138/CD19/CD45/CD56/CD117 and cytoplasmic kappa and light chains expression) from newly diagnosed plasma cell myeloma, PCM cases in both Hospital Kuala Lumpur and Hospital USM. Clinical data and laboratory results retrieved from medical record were analyzed statistically using SPSS26.0. Results: All 78 cases of flow cytometry results in newly diagnosed PCM had more than one aberrant antigen expression with 100% expression rate for both CD38 and CD138 while CD19/CD45/CD56/CD117 in 28.2%, 23.1%, 83.3% and 25.6% respectively. The majority were expressed kappa light chain restriction, 60.3%. A significant association was demonstrated between CD19 markers with serum creatinine (p=0.036). However, there was no significant association between expression of other immunophenotypic markers with its associated factors. Conclusion: Immunophenotyping by multiparametric flow cytometryisausefultoolfordistinguishingneoplasticplasmacellsfromnormalplasma cell where aberrant antigens were present in most of thePCM withaheterogenous immunophenotypic profile of PCM were defined in our population as compared to others. Moreover, there was a significant association demonstrated between CD19 with serum creatinine. However, this result should be confirmed with a bigger sample size. 2021 Thesis http://eprints.usm.my/58840/ http://eprints.usm.my/58840/1/Ling%20Pei%20Chei-24%20pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RC31-1245 Internal medicine
spellingShingle	RC31-1245 Internal medicine Chi, Ling Pei Evaluation of immunophenotypic expressions of plasma cells in plasma cell myeloma patients and its association with prognostic factors and clinical stages
description	Introduction: Neoplastic plasma cell expresses aberrant markers which differ from normal plasma cell was postulated to carry prognostic significance. This study aimed to determine the proportion of immunophenotypic expression of plasma cells in plasma cell myeloma patients at diagnosis and to study the association between these markers with clinical and laboratory parameters. Methods: A retrospective study was carried out from June 2016 till June 2019 by collecting the flow cytometry results (CD38/CD138/CD19/CD45/CD56/CD117 and cytoplasmic kappa and light chains expression) from newly diagnosed plasma cell myeloma, PCM cases in both Hospital Kuala Lumpur and Hospital USM. Clinical data and laboratory results retrieved from medical record were analyzed statistically using SPSS26.0. Results: All 78 cases of flow cytometry results in newly diagnosed PCM had more than one aberrant antigen expression with 100% expression rate for both CD38 and CD138 while CD19/CD45/CD56/CD117 in 28.2%, 23.1%, 83.3% and 25.6% respectively. The majority were expressed kappa light chain restriction, 60.3%. A significant association was demonstrated between CD19 markers with serum creatinine (p=0.036). However, there was no significant association between expression of other immunophenotypic markers with its associated factors. Conclusion: Immunophenotyping by multiparametric flow cytometryisausefultoolfordistinguishingneoplasticplasmacellsfromnormalplasma cell where aberrant antigens were present in most of thePCM withaheterogenous immunophenotypic profile of PCM were defined in our population as compared to others. Moreover, there was a significant association demonstrated between CD19 with serum creatinine. However, this result should be confirmed with a bigger sample size.
format	Thesis
qualification_level	Master's degree
author	Chi, Ling Pei
author_facet	Chi, Ling Pei
author_sort	Chi, Ling Pei
title	Evaluation of immunophenotypic expressions of plasma cells in plasma cell myeloma patients and its association with prognostic factors and clinical stages
title_short	Evaluation of immunophenotypic expressions of plasma cells in plasma cell myeloma patients and its association with prognostic factors and clinical stages
title_full	Evaluation of immunophenotypic expressions of plasma cells in plasma cell myeloma patients and its association with prognostic factors and clinical stages
title_fullStr	Evaluation of immunophenotypic expressions of plasma cells in plasma cell myeloma patients and its association with prognostic factors and clinical stages
title_full_unstemmed	Evaluation of immunophenotypic expressions of plasma cells in plasma cell myeloma patients and its association with prognostic factors and clinical stages
title_sort	evaluation of immunophenotypic expressions of plasma cells in plasma cell myeloma patients and its association with prognostic factors and clinical stages
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2021
url	http://eprints.usm.my/58840/1/Ling%20Pei%20Chei-24%20pages.pdf
_version_	1776101237414952960

Evaluation of immunophenotypic expressions of plasma cells in plasma cell myeloma patients and its association with prognostic factors and clinical stages

Similar Items