Evaluation Of Retinal Nerve Fibre Layer and Macular Thickness In Patients With Hypertensive Disorder In Pregnancy

Objective: Evaluate retinal nerve fibre layer (RNFL) and macular thickness in patients with hypertensive disorder in pregnancy (HDP) compared to healthy pregnant control in third trimester. Methodology: Comparative cross-sectional study conducted in Hospital Universiti Sains Malaysia with 200 HDP p...

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Main Author:	Kahar, Mas Edi Putriku Intan Ab
Format:	Thesis
Language:	English
Published:	2021
Subjects:	RE Ophthalmology
Online Access:	http://eprints.usm.my/58843/1/MAS%20EDI%20PUTRIKU%20INTAN%20AB%20KAHAR-24%20pages.pdf
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id	my-usm-ep.58843
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spelling	my-usm-ep.588432023-07-06T06:42:15Z Evaluation Of Retinal Nerve Fibre Layer and Macular Thickness In Patients With Hypertensive Disorder In Pregnancy 2021 Kahar, Mas Edi Putriku Intan Ab RE Ophthalmology Objective: Evaluate retinal nerve fibre layer (RNFL) and macular thickness in patients with hypertensive disorder in pregnancy (HDP) compared to healthy pregnant control in third trimester. Methodology: Comparative cross-sectional study conducted in Hospital Universiti Sains Malaysia with 200 HDP participants and 50 controls recruited. Clinically stable participants who fulfilled criteria with normal ocular examinations were subjected to optical coherent tomography (OCT) of the right eye. RNFL and macular thickness were evaluated and analysed using SPSS 26.0. Results: Thinner mean RNFL and macular quadrants in HDP groups compared to control were observed; after controlling potential cofounders. Pre-eclampsia showed significant thinning at average and superior RNFL quadrants while, gestational hypertension group showed thinning at average, superior and inferior RNFL regions. Chronic hypertension group showed thinner average RNFL, while chronic hypertension with superimposed pre-eclampsia showed significant thinning at average and superior RNFL quadrants. Thinner outer temporal macular region observed in both gestational and chronic hypertension with superimposed pre-eclampsia groups with mean of 251.00μm and 251.11μm respectively. The latter group also showed thinner outer inferior macular of 259.53μm. Regression analysis between blood pressure (BP) and number of antihypertensive medications with average RNFL and macular thickness showed no significant associations. Conclusion: Mean RNFL thickness was significantly lower in the all HDP groups while macular thickness was significantly lower in the gestational hypertension and chronic hypertension with superimposed pre-eclampsia group. Blood pressure and number of medications showed no significant associations with RNFL and macular thickness. 2021 Thesis http://eprints.usm.my/58843/ http://eprints.usm.my/58843/1/MAS%20EDI%20PUTRIKU%20INTAN%20AB%20KAHAR-24%20pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RE Ophthalmology
spellingShingle	RE Ophthalmology Kahar, Mas Edi Putriku Intan Ab Evaluation Of Retinal Nerve Fibre Layer and Macular Thickness In Patients With Hypertensive Disorder In Pregnancy
description	Objective: Evaluate retinal nerve fibre layer (RNFL) and macular thickness in patients with hypertensive disorder in pregnancy (HDP) compared to healthy pregnant control in third trimester. Methodology: Comparative cross-sectional study conducted in Hospital Universiti Sains Malaysia with 200 HDP participants and 50 controls recruited. Clinically stable participants who fulfilled criteria with normal ocular examinations were subjected to optical coherent tomography (OCT) of the right eye. RNFL and macular thickness were evaluated and analysed using SPSS 26.0. Results: Thinner mean RNFL and macular quadrants in HDP groups compared to control were observed; after controlling potential cofounders. Pre-eclampsia showed significant thinning at average and superior RNFL quadrants while, gestational hypertension group showed thinning at average, superior and inferior RNFL regions. Chronic hypertension group showed thinner average RNFL, while chronic hypertension with superimposed pre-eclampsia showed significant thinning at average and superior RNFL quadrants. Thinner outer temporal macular region observed in both gestational and chronic hypertension with superimposed pre-eclampsia groups with mean of 251.00μm and 251.11μm respectively. The latter group also showed thinner outer inferior macular of 259.53μm. Regression analysis between blood pressure (BP) and number of antihypertensive medications with average RNFL and macular thickness showed no significant associations. Conclusion: Mean RNFL thickness was significantly lower in the all HDP groups while macular thickness was significantly lower in the gestational hypertension and chronic hypertension with superimposed pre-eclampsia group. Blood pressure and number of medications showed no significant associations with RNFL and macular thickness.
format	Thesis
qualification_level	Master's degree
author	Kahar, Mas Edi Putriku Intan Ab
author_facet	Kahar, Mas Edi Putriku Intan Ab
author_sort	Kahar, Mas Edi Putriku Intan Ab
title	Evaluation Of Retinal Nerve Fibre Layer and Macular Thickness In Patients With Hypertensive Disorder In Pregnancy
title_short	Evaluation Of Retinal Nerve Fibre Layer and Macular Thickness In Patients With Hypertensive Disorder In Pregnancy
title_full	Evaluation Of Retinal Nerve Fibre Layer and Macular Thickness In Patients With Hypertensive Disorder In Pregnancy
title_fullStr	Evaluation Of Retinal Nerve Fibre Layer and Macular Thickness In Patients With Hypertensive Disorder In Pregnancy
title_full_unstemmed	Evaluation Of Retinal Nerve Fibre Layer and Macular Thickness In Patients With Hypertensive Disorder In Pregnancy
title_sort	evaluation of retinal nerve fibre layer and macular thickness in patients with hypertensive disorder in pregnancy
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2021
url	http://eprints.usm.my/58843/1/MAS%20EDI%20PUTRIKU%20INTAN%20AB%20KAHAR-24%20pages.pdf
_version_	1776101238127984640

Evaluation Of Retinal Nerve Fibre Layer and Macular Thickness In Patients With Hypertensive Disorder In Pregnancy

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