Association between incidence of white matter hyperintensities in magnetic resonance imaging of the brain and smoking

Background: White matter hyperintensity (WMH) is a common finding on T2 weighted MRI brain or CT Brain among the older subjects. There has been a recognized linkage between the development of Dementia and Alzheimer's disease. Technological advancements in recent years have made the understan...

Full description

Saved in:

Bibliographic Details
Main Author:	Mijol, Mitchell Modi
Format:	Thesis
Language:	English
Published:	2021
Subjects:	RC71-78.7 Examination Diagnosis Including raiography
Online Access:	http://eprints.usm.my/58865/1/MITCHELL%20MODI%20MIJOL-24%20pages.pdf
Tags:	Add Tag No Tags, Be the first to tag this record!

id	my-usm-ep.58865
record_format	uketd_dc
spelling	my-usm-ep.588652023-07-06T06:49:49Z Association between incidence of white matter hyperintensities in magnetic resonance imaging of the brain and smoking 2021 Mijol, Mitchell Modi RC71-78.7 Examination. Diagnosis Including raiography Background: White matter hyperintensity (WMH) is a common finding on T2 weighted MRI brain or CT Brain among the older subjects. There has been a recognized linkage between the development of Dementia and Alzheimer's disease. Technological advancements in recent years have made the understanding of the pathogenesis of WMHs deeper, with several proposed mechanisms, focusing on anatomy, blood-brain barrier disruption, cerebral blood flow autoregulation, venous collagenases, and genetic factors. Smoking has been postulated to have an influence on WMH in several reports. Methods: A retrospective study was conducted in Hospital USM, Kota Bharu, Malaysia with MRI brain of patient aged 18 years and above were reviewed. The MRI must include both T2WI and FLAIR sequences. Patients with gross brain lesions, structural abnormalities, and history suggestive ongoing intracranial infection, inflammatory or demyelinating diseases were excluded. Demographic data regarding pack-years, age of initiation/cessation, duration of smoking, type of cigarettes (nonfiltered, filtered, e-cigarette) was collected and analysed using Pearson’s correlation method, Fisher exact test, and Independent T-test as necessary. Results: There was a significant association between age (p<0.001), smoking status (p<0.001) especially in the ex-smoker and passive smoker group (p=0.022), and comorbidities (p<0.001) with WMH. The mean age of participants in the WMH group was higher than No WMH (p<0.001). For smoking status, a higher prevalence of non smoker was found in the No WMH group. There was a high percentage of participants with no comorbidities reported to be in the No WMH group (n=80, 77.7%). Conclusion: Significant association was found between age, smoking status (Exsmoker and passive smoker), and co-morbidities with WMHs. 2021 Thesis http://eprints.usm.my/58865/ http://eprints.usm.my/58865/1/MITCHELL%20MODI%20MIJOL-24%20pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RC71-78.7 Examination Diagnosis Including raiography
spellingShingle	RC71-78.7 Examination Diagnosis Including raiography Mijol, Mitchell Modi Association between incidence of white matter hyperintensities in magnetic resonance imaging of the brain and smoking
description	Background: White matter hyperintensity (WMH) is a common finding on T2 weighted MRI brain or CT Brain among the older subjects. There has been a recognized linkage between the development of Dementia and Alzheimer's disease. Technological advancements in recent years have made the understanding of the pathogenesis of WMHs deeper, with several proposed mechanisms, focusing on anatomy, blood-brain barrier disruption, cerebral blood flow autoregulation, venous collagenases, and genetic factors. Smoking has been postulated to have an influence on WMH in several reports. Methods: A retrospective study was conducted in Hospital USM, Kota Bharu, Malaysia with MRI brain of patient aged 18 years and above were reviewed. The MRI must include both T2WI and FLAIR sequences. Patients with gross brain lesions, structural abnormalities, and history suggestive ongoing intracranial infection, inflammatory or demyelinating diseases were excluded. Demographic data regarding pack-years, age of initiation/cessation, duration of smoking, type of cigarettes (nonfiltered, filtered, e-cigarette) was collected and analysed using Pearson’s correlation method, Fisher exact test, and Independent T-test as necessary. Results: There was a significant association between age (p<0.001), smoking status (p<0.001) especially in the ex-smoker and passive smoker group (p=0.022), and comorbidities (p<0.001) with WMH. The mean age of participants in the WMH group was higher than No WMH (p<0.001). For smoking status, a higher prevalence of non smoker was found in the No WMH group. There was a high percentage of participants with no comorbidities reported to be in the No WMH group (n=80, 77.7%). Conclusion: Significant association was found between age, smoking status (Exsmoker and passive smoker), and co-morbidities with WMHs.
format	Thesis
qualification_level	Master's degree
author	Mijol, Mitchell Modi
author_facet	Mijol, Mitchell Modi
author_sort	Mijol, Mitchell Modi
title	Association between incidence of white matter hyperintensities in magnetic resonance imaging of the brain and smoking
title_short	Association between incidence of white matter hyperintensities in magnetic resonance imaging of the brain and smoking
title_full	Association between incidence of white matter hyperintensities in magnetic resonance imaging of the brain and smoking
title_fullStr	Association between incidence of white matter hyperintensities in magnetic resonance imaging of the brain and smoking
title_full_unstemmed	Association between incidence of white matter hyperintensities in magnetic resonance imaging of the brain and smoking
title_sort	association between incidence of white matter hyperintensities in magnetic resonance imaging of the brain and smoking
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2021
url	http://eprints.usm.my/58865/1/MITCHELL%20MODI%20MIJOL-24%20pages.pdf
_version_	1776101239321264128

Association between incidence of white matter hyperintensities in magnetic resonance imaging of the brain and smoking

Similar Items