A comparative cross-sectional study on comparison of hyperkalemia measurement between blood gas analyzer in Emergency Department and main laboratory biochemistry analyzer in Hospital Universiti Sains Malaysia

Background: Potassium level is measured for patient with high risk of hyperkalemia in an emergency department (ED) using both blood gas analyser (BGA) and biochemistry analyser (BCA). The purpose of study to evaluate the correlation and agreement of hyperkalemia measurement between these two anal...

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Main Author:	Ismail, Mohd Helmie
Format:	Thesis
Language:	English
Published:	2020
Subjects:	QD146-197 Inorganic chemistry
Online Access:	http://eprints.usm.my/58918/1/MOHD%20HELMIE%20BIN%20ISMAIL-24%20pages.pdf
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spelling	my-usm-ep.589182023-08-06T07:51:12Z A comparative cross-sectional study on comparison of hyperkalemia measurement between blood gas analyzer in Emergency Department and main laboratory biochemistry analyzer in Hospital Universiti Sains Malaysia 2020 Ismail, Mohd Helmie QD146-197 Inorganic chemistry Background: Potassium level is measured for patient with high risk of hyperkalemia in an emergency department (ED) using both blood gas analyser (BGA) and biochemistry analyser (BCA). The purpose of study to evaluate the correlation and agreement of hyperkalemia measurement between these two analysers. Methods and Materials: This is a prospective cross-sectional study was conducted at Hospital Universiti Sains Malaysia (HUSM) from Jun 2018 until May 2019. The blood samples were taken by single pricked from venous blood and were sent separately using 1-ml heparinized syringe and analysed immediately in the emergency department (ED) using BGA (Radiometer, ABL800 FLEX, Denmark) and another sample was sent to the main laboratory of HUSM and analysed by BCA (Architect, C8000, USA). Only patients who had potassium level ³ 5.0 mmol/L on blood gas results were included. The correlation and agreement were evaluated using Passing and Bablok regression, Linear Regression and Bland-Altman test. Result: A total of 173 sample pairs were included. The mean of potassium level based on BGA and BCA were 5.77 mmol/L (SD±0.74) and 6.05 mmol/L (SD±0.91) respectively. There was moderate correlation between two measurements (P<0.001, r: 0.36). The agreement between two measurements showed within acceptable mean difference which was 0.27 mmol/L with 95% limit of agreement was –1.21 mmol/L to 1.73 mmol/L. Conclusion: There is moderate correlation and acceptable agreement in hyperkalemia measurement between BGA to BCA. However, the BGA results tend to be lowered compared to BCA results. Therefore, the clinicians should use the BGA result with caution in certain clinical situation where time-is-of-the-essence to initiate treatment for hyperkalemia. 2020 Thesis http://eprints.usm.my/58918/ http://eprints.usm.my/58918/1/MOHD%20HELMIE%20BIN%20ISMAIL-24%20pages.pdf application/pdf en public masters Pusat Pengajian Sains Perubatan Universiti Sains Malaysia
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	QD146-197 Inorganic chemistry
spellingShingle	QD146-197 Inorganic chemistry Ismail, Mohd Helmie A comparative cross-sectional study on comparison of hyperkalemia measurement between blood gas analyzer in Emergency Department and main laboratory biochemistry analyzer in Hospital Universiti Sains Malaysia
description	Background: Potassium level is measured for patient with high risk of hyperkalemia in an emergency department (ED) using both blood gas analyser (BGA) and biochemistry analyser (BCA). The purpose of study to evaluate the correlation and agreement of hyperkalemia measurement between these two analysers. Methods and Materials: This is a prospective cross-sectional study was conducted at Hospital Universiti Sains Malaysia (HUSM) from Jun 2018 until May 2019. The blood samples were taken by single pricked from venous blood and were sent separately using 1-ml heparinized syringe and analysed immediately in the emergency department (ED) using BGA (Radiometer, ABL800 FLEX, Denmark) and another sample was sent to the main laboratory of HUSM and analysed by BCA (Architect, C8000, USA). Only patients who had potassium level ³ 5.0 mmol/L on blood gas results were included. The correlation and agreement were evaluated using Passing and Bablok regression, Linear Regression and Bland-Altman test. Result: A total of 173 sample pairs were included. The mean of potassium level based on BGA and BCA were 5.77 mmol/L (SD±0.74) and 6.05 mmol/L (SD±0.91) respectively. There was moderate correlation between two measurements (P<0.001, r: 0.36). The agreement between two measurements showed within acceptable mean difference which was 0.27 mmol/L with 95% limit of agreement was –1.21 mmol/L to 1.73 mmol/L. Conclusion: There is moderate correlation and acceptable agreement in hyperkalemia measurement between BGA to BCA. However, the BGA results tend to be lowered compared to BCA results. Therefore, the clinicians should use the BGA result with caution in certain clinical situation where time-is-of-the-essence to initiate treatment for hyperkalemia.
format	Thesis
qualification_level	Master's degree
author	Ismail, Mohd Helmie
author_facet	Ismail, Mohd Helmie
author_sort	Ismail, Mohd Helmie
title	A comparative cross-sectional study on comparison of hyperkalemia measurement between blood gas analyzer in Emergency Department and main laboratory biochemistry analyzer in Hospital Universiti Sains Malaysia
title_short	A comparative cross-sectional study on comparison of hyperkalemia measurement between blood gas analyzer in Emergency Department and main laboratory biochemistry analyzer in Hospital Universiti Sains Malaysia
title_full	A comparative cross-sectional study on comparison of hyperkalemia measurement between blood gas analyzer in Emergency Department and main laboratory biochemistry analyzer in Hospital Universiti Sains Malaysia
title_fullStr	A comparative cross-sectional study on comparison of hyperkalemia measurement between blood gas analyzer in Emergency Department and main laboratory biochemistry analyzer in Hospital Universiti Sains Malaysia
title_full_unstemmed	A comparative cross-sectional study on comparison of hyperkalemia measurement between blood gas analyzer in Emergency Department and main laboratory biochemistry analyzer in Hospital Universiti Sains Malaysia
title_sort	comparative cross-sectional study on comparison of hyperkalemia measurement between blood gas analyzer in emergency department and main laboratory biochemistry analyzer in hospital universiti sains malaysia
granting_institution	Pusat Pengajian Sains Perubatan
granting_department	Universiti Sains Malaysia
publishDate	2020
url	http://eprints.usm.my/58918/1/MOHD%20HELMIE%20BIN%20ISMAIL-24%20pages.pdf
_version_	1776101243618328576

A comparative cross-sectional study on comparison of hyperkalemia measurement between blood gas analyzer in Emergency Department and main laboratory biochemistry analyzer in Hospital Universiti Sains Malaysia

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