In Vitro And In Vivo Toxicity Of Docetaxel-Loaded Polymeric Nanoparticles Formulation For Potential Treatment Of Lung Cancer
Docetaxel is one of chemotherapeutic drug that had been used for treatment of lung cancer for the past two decades. However, the poor solubility of these compounds necessitates the inclusion of surfactant vehicles in their standard solvent system commercial formulations such as Cremophor EL, poly...
Saved in:
| Main Author: | |
|---|---|
| Format: | Thesis |
| Language: | English |
| Published: |
2022
|
| Subjects: | |
| Online Access: | http://eprints.usm.my/59157/1/24%20Pages%20from%20FAISALINA%20BINTI%20AHMAD%20FISOL%20-%20TESIS.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| id |
my-usm-ep.59157 |
|---|---|
| record_format |
uketd_dc |
| spelling |
my-usm-ep.591572023-08-17T01:18:37Z In Vitro And In Vivo Toxicity Of Docetaxel-Loaded Polymeric Nanoparticles Formulation For Potential Treatment Of Lung Cancer 2022-02 Ahmad Fisol, Faisalina RS1-441 Pharmacy and materia medica Docetaxel is one of chemotherapeutic drug that had been used for treatment of lung cancer for the past two decades. However, the poor solubility of these compounds necessitates the inclusion of surfactant vehicles in their standard solvent system commercial formulations such as Cremophor EL, polysorbate 80 and ethanol. These had led to a number of pharmacologic and biologic effects related to these drug formulations such as clinically relevant acute hypersensitivity reactions and peripheral neuropathy. Hence, the aim of the present study was to prepare, characterize, and evaluate toxicity of poly-ɛ-caprolactone nanoparticles containing anticancer drug, docetaxel (DTX) to in order to improve the efficacy of this chemotherapeutic agent. Poly-ɛ-caprolactone nanoparticles containing DTX (DTX-PCL-NP) were prepared by nanoprecipitation method. 2022-02 Thesis http://eprints.usm.my/59157/ http://eprints.usm.my/59157/1/24%20Pages%20from%20FAISALINA%20BINTI%20AHMAD%20FISOL%20-%20TESIS.pdf application/pdf en public phd doctoral Perpustakaan Hamzah Sendut Pusat Pengajian Sains Farmasi |
| institution |
Universiti Sains Malaysia |
| collection |
USM Institutional Repository |
| language |
English |
| topic |
RS1-441 Pharmacy and materia medica |
| spellingShingle |
RS1-441 Pharmacy and materia medica Ahmad Fisol, Faisalina In Vitro And In Vivo Toxicity Of Docetaxel-Loaded Polymeric Nanoparticles Formulation For Potential Treatment Of Lung Cancer |
| description |
Docetaxel is one of chemotherapeutic drug that had been used for treatment of
lung cancer for the past two decades. However, the poor solubility of these compounds
necessitates the inclusion of surfactant vehicles in their standard solvent system
commercial formulations such as Cremophor EL, polysorbate 80 and ethanol. These
had led to a number of pharmacologic and biologic effects related to these drug
formulations such as clinically relevant acute hypersensitivity reactions and peripheral
neuropathy. Hence, the aim of the present study was to prepare, characterize, and
evaluate toxicity of poly-ɛ-caprolactone nanoparticles containing anticancer drug,
docetaxel (DTX) to in order to improve the efficacy of this chemotherapeutic agent.
Poly-ɛ-caprolactone nanoparticles containing DTX (DTX-PCL-NP) were prepared by
nanoprecipitation method. |
| format |
Thesis |
| qualification_name |
Doctor of Philosophy (PhD.) |
| qualification_level |
Doctorate |
| author |
Ahmad Fisol, Faisalina |
| author_facet |
Ahmad Fisol, Faisalina |
| author_sort |
Ahmad Fisol, Faisalina |
| title |
In Vitro And In Vivo Toxicity Of Docetaxel-Loaded Polymeric Nanoparticles Formulation For Potential Treatment Of Lung Cancer |
| title_short |
In Vitro And In Vivo Toxicity Of Docetaxel-Loaded Polymeric Nanoparticles Formulation For Potential Treatment Of Lung Cancer |
| title_full |
In Vitro And In Vivo Toxicity Of Docetaxel-Loaded Polymeric Nanoparticles Formulation For Potential Treatment Of Lung Cancer |
| title_fullStr |
In Vitro And In Vivo Toxicity Of Docetaxel-Loaded Polymeric Nanoparticles Formulation For Potential Treatment Of Lung Cancer |
| title_full_unstemmed |
In Vitro And In Vivo Toxicity Of Docetaxel-Loaded Polymeric Nanoparticles Formulation For Potential Treatment Of Lung Cancer |
| title_sort |
in vitro and in vivo toxicity of docetaxel-loaded polymeric nanoparticles formulation for potential treatment of lung cancer |
| granting_institution |
Perpustakaan Hamzah Sendut |
| granting_department |
Pusat Pengajian Sains Farmasi |
| publishDate |
2022 |
| url |
http://eprints.usm.my/59157/1/24%20Pages%20from%20FAISALINA%20BINTI%20AHMAD%20FISOL%20-%20TESIS.pdf |
| _version_ |
1776101258184097792 |