Biocompatibility And Toxicity Studies On Heterogeneous Tio2-Zno Polymer Nanocomposite With Enhanced Bacterial Activity

Healthcare-associated infections (HAIs) are a major safety concern globally as they contribute to mortality rates amongst patients due to pathogens from direct contact with a contaminated biomedical polymer surface from the indwelling or implanted medical devices. Polymer nanocomposites have become...

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Main Author:	Harun, Nor Hazliana
Format:	Thesis
Language:	English
Published:	2022
Subjects:	R5-130.5 General works
Online Access:	http://eprints.usm.my/59166/1/NOR%20HAZLIANA%20BINTI%20HARUN%20-%20TESIS%20cut.pdf
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id	my-usm-ep.59166
record_format	uketd_dc
spelling	my-usm-ep.591662023-08-17T06:56:43Z Biocompatibility And Toxicity Studies On Heterogeneous Tio2-Zno Polymer Nanocomposite With Enhanced Bacterial Activity 2022-07 Harun, Nor Hazliana R5-130.5 General works Healthcare-associated infections (HAIs) are a major safety concern globally as they contribute to mortality rates amongst patients due to pathogens from direct contact with a contaminated biomedical polymer surface from the indwelling or implanted medical devices. Polymer nanocomposites have become a promising solution for HAIs owing to reactive oxygen species (ROS) and free radicals’ mode of action. In the first section, this work revealed the bacteriostatic and bactericidal potentials of TiO2–ZnO polymer nanocomposite films against HAI pathogens, including multidrug-resistant (MDR) and non-MDR strains. In the second section, the initial analysis of the in vitro bio-interaction responses on fibroblast and blood cell line models showed signs of cell membrane integrity disturbance, which might be due to free radicals’ activities, such as the release of intracellular ROS and Zn ions (Zn2+) during the initial cellular adaptation process on the TiO2–ZnO polymer nanocomposite film. Molecular studies revealed that the cell–polymer nanocomposite film interaction possibly triggered the oxidative stress and pro-inflammatory mechanisms through the principal cascades of Nuclear Factor-κB. Further analysis found that cells could maintain the viability and clonogenic potential and were involved in the anti-apoptosis pathway. Findings suggested the transitory oxidative stress responses of polymer nanocomposite films towards treated cells and not harmful to the cells. 2022-07 Thesis http://eprints.usm.my/59166/ http://eprints.usm.my/59166/1/NOR%20HAZLIANA%20BINTI%20HARUN%20-%20TESIS%20cut.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Institut Perubatan & Pergigian Termaju
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	R5-130.5 General works
spellingShingle	R5-130.5 General works Harun, Nor Hazliana Biocompatibility And Toxicity Studies On Heterogeneous Tio2-Zno Polymer Nanocomposite With Enhanced Bacterial Activity
description	Healthcare-associated infections (HAIs) are a major safety concern globally as they contribute to mortality rates amongst patients due to pathogens from direct contact with a contaminated biomedical polymer surface from the indwelling or implanted medical devices. Polymer nanocomposites have become a promising solution for HAIs owing to reactive oxygen species (ROS) and free radicals’ mode of action. In the first section, this work revealed the bacteriostatic and bactericidal potentials of TiO2–ZnO polymer nanocomposite films against HAI pathogens, including multidrug-resistant (MDR) and non-MDR strains. In the second section, the initial analysis of the in vitro bio-interaction responses on fibroblast and blood cell line models showed signs of cell membrane integrity disturbance, which might be due to free radicals’ activities, such as the release of intracellular ROS and Zn ions (Zn2+) during the initial cellular adaptation process on the TiO2–ZnO polymer nanocomposite film. Molecular studies revealed that the cell–polymer nanocomposite film interaction possibly triggered the oxidative stress and pro-inflammatory mechanisms through the principal cascades of Nuclear Factor-κB. Further analysis found that cells could maintain the viability and clonogenic potential and were involved in the anti-apoptosis pathway. Findings suggested the transitory oxidative stress responses of polymer nanocomposite films towards treated cells and not harmful to the cells.
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Harun, Nor Hazliana
author_facet	Harun, Nor Hazliana
author_sort	Harun, Nor Hazliana
title	Biocompatibility And Toxicity Studies On Heterogeneous Tio2-Zno Polymer Nanocomposite With Enhanced Bacterial Activity
title_short	Biocompatibility And Toxicity Studies On Heterogeneous Tio2-Zno Polymer Nanocomposite With Enhanced Bacterial Activity
title_full	Biocompatibility And Toxicity Studies On Heterogeneous Tio2-Zno Polymer Nanocomposite With Enhanced Bacterial Activity
title_fullStr	Biocompatibility And Toxicity Studies On Heterogeneous Tio2-Zno Polymer Nanocomposite With Enhanced Bacterial Activity
title_full_unstemmed	Biocompatibility And Toxicity Studies On Heterogeneous Tio2-Zno Polymer Nanocomposite With Enhanced Bacterial Activity
title_sort	biocompatibility and toxicity studies on heterogeneous tio2-zno polymer nanocomposite with enhanced bacterial activity
granting_institution	Universiti Sains Malaysia
granting_department	Institut Perubatan & Pergigian Termaju
publishDate	2022
url	http://eprints.usm.my/59166/1/NOR%20HAZLIANA%20BINTI%20HARUN%20-%20TESIS%20cut.pdf
_version_	1776101259607015424

Biocompatibility And Toxicity Studies On Heterogeneous Tio2-Zno Polymer Nanocomposite With Enhanced Bacterial Activity

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