Development Of Semi-Solid Self-Emulsifying Drug Delivery System (Sedds) Using Liquid Model Drug For Oral Drug Delivery Application

A study was conducted to formulate a semi-solid SEDDS with enhanced bioavailability using Gelucire® 44/14 as the self-emulsifying agent and a tocotrienols mixture (EVNol™ 50%) as the liquid model drug. A series of formulations with different proportions of tocotrienol extract and Gelucire® 44/14 wer...

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Main Author:	Abu Bakar, Syazana
Format:	Thesis
Language:	English
Published:	2022
Subjects:	RS1-441 Pharmacy and materia medica
Online Access:	http://eprints.usm.my/59321/1/24%20Pages%20from%20SYAZANA%20BINTI%20ABU%20BAKAR%20-%20TESIS.pdf
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id	my-usm-ep.59321
record_format	uketd_dc
spelling	my-usm-ep.593212023-09-04T01:19:49Z Development Of Semi-Solid Self-Emulsifying Drug Delivery System (Sedds) Using Liquid Model Drug For Oral Drug Delivery Application 2022-02 Abu Bakar, Syazana RS1-441 Pharmacy and materia medica A study was conducted to formulate a semi-solid SEDDS with enhanced bioavailability using Gelucire® 44/14 as the self-emulsifying agent and a tocotrienols mixture (EVNol™ 50%) as the liquid model drug. A series of formulations with different proportions of tocotrienol extract and Gelucire® 44/14 were prepared and evaluated. Finally, a formulation with 1:1 ratio of tocotrienols to Gelucire® 44/14 with the addition of 2.5% of propylene glycol was found most suitable to obtain a semi-solid SEDDS with satisfactory self-emulsifying properties. From a series of in vitro studies, the formulation was able to self-emulsify under gentle agitation and formed an oil in water emulsion within 3 minutes upon contact with the dissolution media. The emulsion formed was stable, with the emulsion particle size distribution achieving nano-range. Subsequently, 2022-02 Thesis http://eprints.usm.my/59321/ http://eprints.usm.my/59321/1/24%20Pages%20from%20SYAZANA%20BINTI%20ABU%20BAKAR%20-%20TESIS.pdf application/pdf en public phd doctoral Perpustakaan Hamzah Sendut Pusat Pengajian Sains Farmasi
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RS1-441 Pharmacy and materia medica
spellingShingle	RS1-441 Pharmacy and materia medica Abu Bakar, Syazana Development Of Semi-Solid Self-Emulsifying Drug Delivery System (Sedds) Using Liquid Model Drug For Oral Drug Delivery Application
description	A study was conducted to formulate a semi-solid SEDDS with enhanced bioavailability using Gelucire® 44/14 as the self-emulsifying agent and a tocotrienols mixture (EVNol™ 50%) as the liquid model drug. A series of formulations with different proportions of tocotrienol extract and Gelucire® 44/14 were prepared and evaluated. Finally, a formulation with 1:1 ratio of tocotrienols to Gelucire® 44/14 with the addition of 2.5% of propylene glycol was found most suitable to obtain a semi-solid SEDDS with satisfactory self-emulsifying properties. From a series of in vitro studies, the formulation was able to self-emulsify under gentle agitation and formed an oil in water emulsion within 3 minutes upon contact with the dissolution media. The emulsion formed was stable, with the emulsion particle size distribution achieving nano-range. Subsequently,
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Abu Bakar, Syazana
author_facet	Abu Bakar, Syazana
author_sort	Abu Bakar, Syazana
title	Development Of Semi-Solid Self-Emulsifying Drug Delivery System (Sedds) Using Liquid Model Drug For Oral Drug Delivery Application
title_short	Development Of Semi-Solid Self-Emulsifying Drug Delivery System (Sedds) Using Liquid Model Drug For Oral Drug Delivery Application
title_full	Development Of Semi-Solid Self-Emulsifying Drug Delivery System (Sedds) Using Liquid Model Drug For Oral Drug Delivery Application
title_fullStr	Development Of Semi-Solid Self-Emulsifying Drug Delivery System (Sedds) Using Liquid Model Drug For Oral Drug Delivery Application
title_full_unstemmed	Development Of Semi-Solid Self-Emulsifying Drug Delivery System (Sedds) Using Liquid Model Drug For Oral Drug Delivery Application
title_sort	development of semi-solid self-emulsifying drug delivery system (sedds) using liquid model drug for oral drug delivery application
granting_institution	Perpustakaan Hamzah Sendut
granting_department	Pusat Pengajian Sains Farmasi
publishDate	2022
url	http://eprints.usm.my/59321/1/24%20Pages%20from%20SYAZANA%20BINTI%20ABU%20BAKAR%20-%20TESIS.pdf
_version_	1776101287804272640

Development Of Semi-Solid Self-Emulsifying Drug Delivery System (Sedds) Using Liquid Model Drug For Oral Drug Delivery Application

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