Effects Of Syzygium Polyanthum (Wight) Walp. Leaf Extract With Potential Cholinergic Activity On Cognitive Function In Chronic Cerebral Hypoperfusion Rat Model

Vascular dementia (VaD), is the most common type of dementia in the ageing population, initiated by chronic cerebral hypoperfusion (CCH). Cholinergic system dysfunction in the central nervous system (CNS) has been recognized as one of the main reasons for learning and memory impairment in VaD patien...

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Main Author:	Kumaran, Kesevan Rajah
Format:	Thesis
Language:	English
Published:	2021
Subjects:	RS1-441 Pharmacy and materia medica
Online Access:	http://eprints.usm.my/59365/1/KESEVAN%20AL%20RAJAH%20KUMARAN%20-%20TESIS24.pdf
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id	my-usm-ep.59365
record_format	uketd_dc
spelling	my-usm-ep.593652023-09-12T08:08:57Z Effects Of Syzygium Polyanthum (Wight) Walp. Leaf Extract With Potential Cholinergic Activity On Cognitive Function In Chronic Cerebral Hypoperfusion Rat Model 2021-12 Kumaran, Kesevan Rajah RS1-441 Pharmacy and materia medica Vascular dementia (VaD), is the most common type of dementia in the ageing population, initiated by chronic cerebral hypoperfusion (CCH). Cholinergic system dysfunction in the central nervous system (CNS) has been recognized as one of the main reasons for learning and memory impairment in VaD patients. Therefore, medications that restore the level of acetylcholine (ACh) neurotransmitter by inhibiting cholinesterase activity have been proposed as a potential candidate to treat VaD patients. Present study was conducted to evaluate the effect of four methanol plant extracts with anti-cholinesterase activity in POBCCA rats. The selected plant extracts were Coccoloba uvifera (stems), Mimusops elengi (leaves), Syzygium aqueum (leaves) and Syzygium polyanthum (leaves). The effects of these plants (100 and 200 mg/kg) on learning and memory were evaluated using novel object recognition (NOR) and morris water maze (MWM) tests. The behavioral tasks results revealed S. polyanthum (100 and 200 mg/kg) and S. aqueum (200 mg/kg) extracts improved short- (p < 0.05) and long-term (p < 0.05) recognition memories during NOR. Besides that, M. elengi and S. aqueum (200 mg/kg) along with S. polyanthum (100 and 200 mg/kg) extracts improved spatial learning (day 4: p < 0.05; day 5: p < 0.05) and S. polyanthum exract (100 and 200 mg/kg) improved reference memories (p < 0.05) in MWM test. 2021-12 Thesis http://eprints.usm.my/59365/ http://eprints.usm.my/59365/1/KESEVAN%20AL%20RAJAH%20KUMARAN%20-%20TESIS24.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Pusat Pengajian Sains Farmasi
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RS1-441 Pharmacy and materia medica
spellingShingle	RS1-441 Pharmacy and materia medica Kumaran, Kesevan Rajah Effects Of Syzygium Polyanthum (Wight) Walp. Leaf Extract With Potential Cholinergic Activity On Cognitive Function In Chronic Cerebral Hypoperfusion Rat Model
description	Vascular dementia (VaD), is the most common type of dementia in the ageing population, initiated by chronic cerebral hypoperfusion (CCH). Cholinergic system dysfunction in the central nervous system (CNS) has been recognized as one of the main reasons for learning and memory impairment in VaD patients. Therefore, medications that restore the level of acetylcholine (ACh) neurotransmitter by inhibiting cholinesterase activity have been proposed as a potential candidate to treat VaD patients. Present study was conducted to evaluate the effect of four methanol plant extracts with anti-cholinesterase activity in POBCCA rats. The selected plant extracts were Coccoloba uvifera (stems), Mimusops elengi (leaves), Syzygium aqueum (leaves) and Syzygium polyanthum (leaves). The effects of these plants (100 and 200 mg/kg) on learning and memory were evaluated using novel object recognition (NOR) and morris water maze (MWM) tests. The behavioral tasks results revealed S. polyanthum (100 and 200 mg/kg) and S. aqueum (200 mg/kg) extracts improved short- (p < 0.05) and long-term (p < 0.05) recognition memories during NOR. Besides that, M. elengi and S. aqueum (200 mg/kg) along with S. polyanthum (100 and 200 mg/kg) extracts improved spatial learning (day 4: p < 0.05; day 5: p < 0.05) and S. polyanthum exract (100 and 200 mg/kg) improved reference memories (p < 0.05) in MWM test.
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Kumaran, Kesevan Rajah
author_facet	Kumaran, Kesevan Rajah
author_sort	Kumaran, Kesevan Rajah
title	Effects Of Syzygium Polyanthum (Wight) Walp. Leaf Extract With Potential Cholinergic Activity On Cognitive Function In Chronic Cerebral Hypoperfusion Rat Model
title_short	Effects Of Syzygium Polyanthum (Wight) Walp. Leaf Extract With Potential Cholinergic Activity On Cognitive Function In Chronic Cerebral Hypoperfusion Rat Model
title_full	Effects Of Syzygium Polyanthum (Wight) Walp. Leaf Extract With Potential Cholinergic Activity On Cognitive Function In Chronic Cerebral Hypoperfusion Rat Model
title_fullStr	Effects Of Syzygium Polyanthum (Wight) Walp. Leaf Extract With Potential Cholinergic Activity On Cognitive Function In Chronic Cerebral Hypoperfusion Rat Model
title_full_unstemmed	Effects Of Syzygium Polyanthum (Wight) Walp. Leaf Extract With Potential Cholinergic Activity On Cognitive Function In Chronic Cerebral Hypoperfusion Rat Model
title_sort	effects of syzygium polyanthum (wight) walp. leaf extract with potential cholinergic activity on cognitive function in chronic cerebral hypoperfusion rat model
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Farmasi
publishDate	2021
url	http://eprints.usm.my/59365/1/KESEVAN%20AL%20RAJAH%20KUMARAN%20-%20TESIS24.pdf
_version_	1783729541264441344

Effects Of Syzygium Polyanthum (Wight) Walp. Leaf Extract With Potential Cholinergic Activity On Cognitive Function In Chronic Cerebral Hypoperfusion Rat Model

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