Antihypertensive And Renoprotective Effects Of Hibiscus Sabdariffa Extracts On Doca-Salt Induced And Spontaneously Hypertensive Rats

Antihypertensive And Renoprotective Effects Of Hibiscus Sabdariffa Extracts On Doca-Salt Induced And Spontaneously Hypertensive Rats

Hibiscus sabdariffa is widely used as a folk medicine for hypertension treatment throughout the world. The present study was carried out to develop a standardised, industry friendly and stable oral dosage form incorporating the effective dose of Hibiscus sabdariffa calyces extract, as determined thr...

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Main Author: Ho, Yoke Mei
Format: Thesis
Language:English
Published: 2022
Subjects:
RS1-441 Pharmacy and materia medica
Online Access:http://eprints.usm.my/59417/1/HO%20YOKE%20MEI%20-%20TESIS%20cut.pdf
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spelling my-usm-ep.594172023-09-21T08:59:40Z Antihypertensive And Renoprotective Effects Of Hibiscus Sabdariffa Extracts On Doca-Salt Induced And Spontaneously Hypertensive Rats 2022-07 Ho, Yoke Mei RS1-441 Pharmacy and materia medica Hibiscus sabdariffa is widely used as a folk medicine for hypertension treatment throughout the world. The present study was carried out to develop a standardised, industry friendly and stable oral dosage form incorporating the effective dose of Hibiscus sabdariffa calyces extract, as determined through three animal models, namely spontaneous hypertensive rat model (SHR), DOCA-salt induced hypertensive model and normotensive rat model. Delphinidin 3-sambubioside and cyanidin 3-sambubioside are the major anthocyanins in Hibiscus sabdariffa calyces extract and were known to be very unstable under different storage conditions. The most suitable extraction and concentration methods for Hibiscus sabdariffa calyces water and 50 % ethanolic extracts were maceration and spray dry methods because these methods produced higher total phenolic contents, total flavonoid contents, antioxidant capacity, and anthocyanin contents than reflux boiling and rotary evaporation methods. Both Hibiscus sabdariffa calyces water and 50 % ethanolic extracts were then subjected to pharmacological study and it was found that Hibiscus sabdariffa calyces water extract showed a more potent anti-hypertensive effect. Hibiscus sabdariffa calyces water extract at 500 mg/kg dose was the most effective in reducing blood pressure based on the systolic and diastolic blood pressures in the SHR model and DOCA-salt induced hypertensive model. 2022-07 Thesis http://eprints.usm.my/59417/ http://eprints.usm.my/59417/1/HO%20YOKE%20MEI%20-%20TESIS%20cut.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Pusat Pengajian Sains Farmasi
institution Universiti Sains Malaysia
collection USM Institutional Repository
language English
topic RS1-441 Pharmacy and materia medica
spellingShingle RS1-441 Pharmacy and materia medica
Ho, Yoke Mei
Antihypertensive And Renoprotective Effects Of Hibiscus Sabdariffa Extracts On Doca-Salt Induced And Spontaneously Hypertensive Rats
description Hibiscus sabdariffa is widely used as a folk medicine for hypertension treatment throughout the world. The present study was carried out to develop a standardised, industry friendly and stable oral dosage form incorporating the effective dose of Hibiscus sabdariffa calyces extract, as determined through three animal models, namely spontaneous hypertensive rat model (SHR), DOCA-salt induced hypertensive model and normotensive rat model. Delphinidin 3-sambubioside and cyanidin 3-sambubioside are the major anthocyanins in Hibiscus sabdariffa calyces extract and were known to be very unstable under different storage conditions. The most suitable extraction and concentration methods for Hibiscus sabdariffa calyces water and 50 % ethanolic extracts were maceration and spray dry methods because these methods produced higher total phenolic contents, total flavonoid contents, antioxidant capacity, and anthocyanin contents than reflux boiling and rotary evaporation methods. Both Hibiscus sabdariffa calyces water and 50 % ethanolic extracts were then subjected to pharmacological study and it was found that Hibiscus sabdariffa calyces water extract showed a more potent anti-hypertensive effect. Hibiscus sabdariffa calyces water extract at 500 mg/kg dose was the most effective in reducing blood pressure based on the systolic and diastolic blood pressures in the SHR model and DOCA-salt induced hypertensive model.
format Thesis
qualification_name Doctor of Philosophy (PhD.)
qualification_level Doctorate
author Ho, Yoke Mei
author_facet Ho, Yoke Mei
author_sort Ho, Yoke Mei
title Antihypertensive And Renoprotective Effects Of Hibiscus Sabdariffa Extracts On Doca-Salt Induced And Spontaneously Hypertensive Rats
title_short Antihypertensive And Renoprotective Effects Of Hibiscus Sabdariffa Extracts On Doca-Salt Induced And Spontaneously Hypertensive Rats
title_full Antihypertensive And Renoprotective Effects Of Hibiscus Sabdariffa Extracts On Doca-Salt Induced And Spontaneously Hypertensive Rats
title_fullStr Antihypertensive And Renoprotective Effects Of Hibiscus Sabdariffa Extracts On Doca-Salt Induced And Spontaneously Hypertensive Rats
title_full_unstemmed Antihypertensive And Renoprotective Effects Of Hibiscus Sabdariffa Extracts On Doca-Salt Induced And Spontaneously Hypertensive Rats
title_sort antihypertensive and renoprotective effects of hibiscus sabdariffa extracts on doca-salt induced and spontaneously hypertensive rats
granting_institution Universiti Sains Malaysia
granting_department Pusat Pengajian Sains Farmasi
publishDate 2022
url http://eprints.usm.my/59417/1/HO%20YOKE%20MEI%20-%20TESIS%20cut.pdf
_version_ 1783729552814505984

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