Development And Evaluation Of A Gastroretentive Drug Delivery System For Thiamine Hydrochloride
A gastroretentive tablet system was developed and evaluated for the oral delivery of thiamine hydrochloride as the model drug with an absorption window. A simple, specific and sensitive liquid chromatographic tandem mass spectrometric method was first developed for studying the oral bioavailabili...
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2013
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my-usm-ep.594692023-10-11T01:35:19Z Development And Evaluation Of A Gastroretentive Drug Delivery System For Thiamine Hydrochloride 2013-03 Kam, Li Ying RS1-441 Pharmacy and materia medica A gastroretentive tablet system was developed and evaluated for the oral delivery of thiamine hydrochloride as the model drug with an absorption window. A simple, specific and sensitive liquid chromatographic tandem mass spectrometric method was first developed for studying the oral bioavailability of thiamine hydrochloride using rats. It was found that the oral bioavailability of thiamine was poor and erratic, but the poor bioavailability was not attributed to stability problem in the gastrointestinal tract. Rather, it was due to its restricted absorption in the upper region of the small intestine. The oral bioavailability of thiamine was also found to be influenced by CYP3A4 and P-glycoprotein (P-gp). 2013-03 Thesis http://eprints.usm.my/59469/ http://eprints.usm.my/59469/1/24%20Pages%20from%2000001780165.pdf application/pdf en public phd doctoral Perpustakaan Hamzah Sendut Pusat Pengajian Sains Farmasi |
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Universiti Sains Malaysia |
| collection |
USM Institutional Repository |
| language |
English |
| topic |
RS1-441 Pharmacy and materia medica |
| spellingShingle |
RS1-441 Pharmacy and materia medica Kam, Li Ying Development And Evaluation Of A Gastroretentive Drug Delivery System For Thiamine Hydrochloride |
| description |
A gastroretentive tablet system was developed and evaluated for the oral delivery of
thiamine hydrochloride as the model drug with an absorption window. A simple,
specific and sensitive liquid chromatographic tandem mass spectrometric method
was first developed for studying the oral bioavailability of thiamine hydrochloride
using rats. It was found that the oral bioavailability of thiamine was poor and erratic,
but the poor bioavailability was not attributed to stability problem in the
gastrointestinal tract. Rather, it was due to its restricted absorption in the upper
region of the small intestine. The oral bioavailability of thiamine was also found to
be influenced by CYP3A4 and P-glycoprotein (P-gp). |
| format |
Thesis |
| qualification_name |
Doctor of Philosophy (PhD.) |
| qualification_level |
Doctorate |
| author |
Kam, Li Ying |
| author_facet |
Kam, Li Ying |
| author_sort |
Kam, Li Ying |
| title |
Development And Evaluation Of A Gastroretentive Drug Delivery System For Thiamine Hydrochloride |
| title_short |
Development And Evaluation Of A Gastroretentive Drug Delivery System For Thiamine Hydrochloride |
| title_full |
Development And Evaluation Of A Gastroretentive Drug Delivery System For Thiamine Hydrochloride |
| title_fullStr |
Development And Evaluation Of A Gastroretentive Drug Delivery System For Thiamine Hydrochloride |
| title_full_unstemmed |
Development And Evaluation Of A Gastroretentive Drug Delivery System For Thiamine Hydrochloride |
| title_sort |
development and evaluation of a gastroretentive drug delivery system for thiamine hydrochloride |
| granting_institution |
Perpustakaan Hamzah Sendut |
| granting_department |
Pusat Pengajian Sains Farmasi |
| publishDate |
2013 |
| url |
http://eprints.usm.my/59469/1/24%20Pages%20from%2000001780165.pdf |
| _version_ |
1783729562568359936 |