Molecular Dynamics Studies: The Interaction Of Erythromycin A With A Single Base Substitution Of 50s Ribosomal Subunit
The objective of the study is to find how the interactions erythromycin A (ERYA), a 14-membered ring macrolide, with a single base substitution from adenine to guanine on the large ribosomal subunit at 2041. This single base substitution has been reported of to be one of the resistance modes in the...
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2012
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my-usm-ep.594832023-10-12T08:37:56Z Molecular Dynamics Studies: The Interaction Of Erythromycin A With A Single Base Substitution Of 50s Ribosomal Subunit 2012-09 Mohamad Zobir, Siti Zuraidah RS1-441 Pharmacy and materia medica The objective of the study is to find how the interactions erythromycin A (ERYA), a 14-membered ring macrolide, with a single base substitution from adenine to guanine on the large ribosomal subunit at 2041. This single base substitution has been reported of to be one of the resistance modes in the binding of macrolides. Molecular dynamics (MD) simulation is a great tool that was used in this study to explain at the molecular level why resistance happens when a single base substitution takes place at 2041, one of the residues in PTe. 2012-09 Thesis http://eprints.usm.my/59483/ http://eprints.usm.my/59483/1/Siti%20Zuraidah%20binti%20Mohamad%20Zobir%20cut.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Farmasi (School of Pharmacy) |
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Universiti Sains Malaysia |
| collection |
USM Institutional Repository |
| language |
English |
| topic |
RS1-441 Pharmacy and materia medica |
| spellingShingle |
RS1-441 Pharmacy and materia medica Mohamad Zobir, Siti Zuraidah Molecular Dynamics Studies: The Interaction Of Erythromycin A With A Single Base Substitution Of 50s Ribosomal Subunit |
| description |
The objective of the study is to find how the interactions erythromycin A (ERYA), a 14-membered ring macrolide, with a single base substitution from adenine to guanine on the large ribosomal subunit at 2041. This single base
substitution has been reported of to be one of the resistance modes in the binding of macrolides. Molecular dynamics (MD) simulation is a great tool that was used in this study to explain at the molecular level why resistance happens when a single base substitution takes place at 2041, one of the residues in PTe. |
| format |
Thesis |
| qualification_level |
Master's degree |
| author |
Mohamad Zobir, Siti Zuraidah |
| author_facet |
Mohamad Zobir, Siti Zuraidah |
| author_sort |
Mohamad Zobir, Siti Zuraidah |
| title |
Molecular Dynamics Studies: The Interaction Of
Erythromycin A With A Single Base Substitution Of 50s
Ribosomal Subunit |
| title_short |
Molecular Dynamics Studies: The Interaction Of
Erythromycin A With A Single Base Substitution Of 50s
Ribosomal Subunit |
| title_full |
Molecular Dynamics Studies: The Interaction Of
Erythromycin A With A Single Base Substitution Of 50s
Ribosomal Subunit |
| title_fullStr |
Molecular Dynamics Studies: The Interaction Of
Erythromycin A With A Single Base Substitution Of 50s
Ribosomal Subunit |
| title_full_unstemmed |
Molecular Dynamics Studies: The Interaction Of
Erythromycin A With A Single Base Substitution Of 50s
Ribosomal Subunit |
| title_sort |
molecular dynamics studies: the interaction of
erythromycin a with a single base substitution of 50s
ribosomal subunit |
| granting_institution |
Universiti Sains Malaysia |
| granting_department |
Pusat Pengajian Sains Farmasi (School of Pharmacy) |
| publishDate |
2012 |
| url |
http://eprints.usm.my/59483/1/Siti%20Zuraidah%20binti%20Mohamad%20Zobir%20cut.pdf |
| _version_ |
1783729565122691072 |