Evaluation Of Mitragyna Speciosa Korth. (Ketum) Extracts Prepared By Accelerated Solvent Extraction Technique, On Antinociceptive And Cytotoxicity Effects

Mitragyna speciosa Korth. (Ketum) leaves are well known for their psychoactive and analgesic properties. Mitragynine, is the principal alkaloid of ketum leaf, is a well-known factor that contributes to ketum’s pharmacological activities. The present study underlined the use of green solvent and gree...

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Main Author:	Goh, Yong Sean
Format:	Thesis
Language:	English
Published:	2021
Subjects:	RM300-666 Drugs and their actions
Online Access:	http://eprints.usm.my/59534/1/24%20Pages%20from%20GOH%20YONG%20SEAN.pdf
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id	my-usm-ep.59534
record_format	uketd_dc
spelling	my-usm-ep.595342023-10-24T03:21:57Z Evaluation Of Mitragyna Speciosa Korth. (Ketum) Extracts Prepared By Accelerated Solvent Extraction Technique, On Antinociceptive And Cytotoxicity Effects 2021-12 Goh, Yong Sean RM300-666 Drugs and their actions Mitragyna speciosa Korth. (Ketum) leaves are well known for their psychoactive and analgesic properties. Mitragynine, is the principal alkaloid of ketum leaf, is a well-known factor that contributes to ketum’s pharmacological activities. The present study underlined the use of green solvent and green extraction technique for the yield of a better and safe ketum extract. At first, ketum was extracted with pure water using conventional extractions, Soxhlet, and maceration, as well as modern extraction techniques, ultrasound-assisted extraction (UAE), and accelerated solvent extraction (ASE) techniques. Subsequently, two green extraction techniques which are ASE, and UAE were selected. Solvents such as water, methanol, ethanol, and ethyl acetate were used in the optimisation of ASE and UAE. Comparing both extractions, ASE demonstrated a better dry yield (0.53 – 2.91 g) with consistent mitragynine content (6.53 – 7.19 %), shorter time (5 minutes), and reduced solvent usage (< 100 mL). 2021-12 Thesis http://eprints.usm.my/59534/ http://eprints.usm.my/59534/1/24%20Pages%20from%20GOH%20YONG%20SEAN.pdf application/pdf en public masters Perpustakaan Hamzah Sendut Pusat Penyelidikan Dadah & Ubat-Ubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RM300-666 Drugs and their actions
spellingShingle	RM300-666 Drugs and their actions Goh, Yong Sean Evaluation Of Mitragyna Speciosa Korth. (Ketum) Extracts Prepared By Accelerated Solvent Extraction Technique, On Antinociceptive And Cytotoxicity Effects
description	Mitragyna speciosa Korth. (Ketum) leaves are well known for their psychoactive and analgesic properties. Mitragynine, is the principal alkaloid of ketum leaf, is a well-known factor that contributes to ketum’s pharmacological activities. The present study underlined the use of green solvent and green extraction technique for the yield of a better and safe ketum extract. At first, ketum was extracted with pure water using conventional extractions, Soxhlet, and maceration, as well as modern extraction techniques, ultrasound-assisted extraction (UAE), and accelerated solvent extraction (ASE) techniques. Subsequently, two green extraction techniques which are ASE, and UAE were selected. Solvents such as water, methanol, ethanol, and ethyl acetate were used in the optimisation of ASE and UAE. Comparing both extractions, ASE demonstrated a better dry yield (0.53 – 2.91 g) with consistent mitragynine content (6.53 – 7.19 %), shorter time (5 minutes), and reduced solvent usage (< 100 mL).
format	Thesis
qualification_level	Master's degree
author	Goh, Yong Sean
author_facet	Goh, Yong Sean
author_sort	Goh, Yong Sean
title	Evaluation Of Mitragyna Speciosa Korth. (Ketum) Extracts Prepared By Accelerated Solvent Extraction Technique, On Antinociceptive And Cytotoxicity Effects
title_short	Evaluation Of Mitragyna Speciosa Korth. (Ketum) Extracts Prepared By Accelerated Solvent Extraction Technique, On Antinociceptive And Cytotoxicity Effects
title_full	Evaluation Of Mitragyna Speciosa Korth. (Ketum) Extracts Prepared By Accelerated Solvent Extraction Technique, On Antinociceptive And Cytotoxicity Effects
title_fullStr	Evaluation Of Mitragyna Speciosa Korth. (Ketum) Extracts Prepared By Accelerated Solvent Extraction Technique, On Antinociceptive And Cytotoxicity Effects
title_full_unstemmed	Evaluation Of Mitragyna Speciosa Korth. (Ketum) Extracts Prepared By Accelerated Solvent Extraction Technique, On Antinociceptive And Cytotoxicity Effects
title_sort	evaluation of mitragyna speciosa korth. (ketum) extracts prepared by accelerated solvent extraction technique, on antinociceptive and cytotoxicity effects
granting_institution	Perpustakaan Hamzah Sendut
granting_department	Pusat Penyelidikan Dadah & Ubat-Ubatan
publishDate	2021
url	http://eprints.usm.my/59534/1/24%20Pages%20from%20GOH%20YONG%20SEAN.pdf
_version_	1783729572164927488

Evaluation Of Mitragyna Speciosa Korth. (Ketum) Extracts Prepared By Accelerated Solvent Extraction Technique, On Antinociceptive And Cytotoxicity Effects

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