Assessment Of Antitumor Activity Of Standardized Polyalthia Longifolia Leaf Extract In Hela Cell Tumor Xenograft Mouse Model

P. longifolia is a traditional medicinal plant with a rich source of biologically active phytochemicals. Investigations on methanolic leaf extract were reported to exert potent in vitro anticancer effects on HeLa human cervical cancer cells. Current treatment strategies for cervical cancer are facin...

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Main Author:	Braganza, Cilwyn Shalitha
Format:	Thesis
Language:	English
Published:	2022
Subjects:	R5-920 Medicine (General)
Online Access:	http://eprints.usm.my/59682/1/24%20Pages%20from%20CILWYN%20SHALITHA%20BRAGANZA%20-%20TESIS.pdf
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id	my-usm-ep.59682
record_format	uketd_dc
spelling	my-usm-ep.596822023-12-15T02:08:45Z Assessment Of Antitumor Activity Of Standardized Polyalthia Longifolia Leaf Extract In Hela Cell Tumor Xenograft Mouse Model 2022-08 Braganza, Cilwyn Shalitha R5-920 Medicine (General) P. longifolia is a traditional medicinal plant with a rich source of biologically active phytochemicals. Investigations on methanolic leaf extract were reported to exert potent in vitro anticancer effects on HeLa human cervical cancer cells. Current treatment strategies for cervical cancer are facing challenges such as increased drug toxicity, chemoresistance, and limited treatment options, thus making it imperative for the discovery of safe and effective green anticancer agents. Though P. longifolia is a promising anticancer plant, the in vitro findings by themselves are insufficient to translate to human use and therefore require in vivo preclinical testing. Currently, there are no reports on further investigation of P. longifolia leaf extracts on in vivo animal tumor models, which limits the clinical utility of this plant. Hence this study was conducted to evaluate the in vivo antitumor effects of P. longifolia methanolic leaf extract on HeLa cells xenografted tumors developed in athymic nude mice. 2022-08 Thesis http://eprints.usm.my/59682/ http://eprints.usm.my/59682/1/24%20Pages%20from%20CILWYN%20SHALITHA%20BRAGANZA%20-%20TESIS.pdf application/pdf en public phd doctoral Perpustakaan Hamzah Sendut Institut Penyelidikan Perubatan Molekul
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	R5-920 Medicine (General)
spellingShingle	R5-920 Medicine (General) Braganza, Cilwyn Shalitha Assessment Of Antitumor Activity Of Standardized Polyalthia Longifolia Leaf Extract In Hela Cell Tumor Xenograft Mouse Model
description	P. longifolia is a traditional medicinal plant with a rich source of biologically active phytochemicals. Investigations on methanolic leaf extract were reported to exert potent in vitro anticancer effects on HeLa human cervical cancer cells. Current treatment strategies for cervical cancer are facing challenges such as increased drug toxicity, chemoresistance, and limited treatment options, thus making it imperative for the discovery of safe and effective green anticancer agents. Though P. longifolia is a promising anticancer plant, the in vitro findings by themselves are insufficient to translate to human use and therefore require in vivo preclinical testing. Currently, there are no reports on further investigation of P. longifolia leaf extracts on in vivo animal tumor models, which limits the clinical utility of this plant. Hence this study was conducted to evaluate the in vivo antitumor effects of P. longifolia methanolic leaf extract on HeLa cells xenografted tumors developed in athymic nude mice.
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Braganza, Cilwyn Shalitha
author_facet	Braganza, Cilwyn Shalitha
author_sort	Braganza, Cilwyn Shalitha
title	Assessment Of Antitumor Activity Of Standardized Polyalthia Longifolia Leaf Extract In Hela Cell Tumor Xenograft Mouse Model
title_short	Assessment Of Antitumor Activity Of Standardized Polyalthia Longifolia Leaf Extract In Hela Cell Tumor Xenograft Mouse Model
title_full	Assessment Of Antitumor Activity Of Standardized Polyalthia Longifolia Leaf Extract In Hela Cell Tumor Xenograft Mouse Model
title_fullStr	Assessment Of Antitumor Activity Of Standardized Polyalthia Longifolia Leaf Extract In Hela Cell Tumor Xenograft Mouse Model
title_full_unstemmed	Assessment Of Antitumor Activity Of Standardized Polyalthia Longifolia Leaf Extract In Hela Cell Tumor Xenograft Mouse Model
title_sort	assessment of antitumor activity of standardized polyalthia longifolia leaf extract in hela cell tumor xenograft mouse model
granting_institution	Perpustakaan Hamzah Sendut
granting_department	Institut Penyelidikan Perubatan Molekul
publishDate	2022
url	http://eprints.usm.my/59682/1/24%20Pages%20from%20CILWYN%20SHALITHA%20BRAGANZA%20-%20TESIS.pdf
_version_	1794024033932541952

Assessment Of Antitumor Activity Of Standardized Polyalthia Longifolia Leaf Extract In Hela Cell Tumor Xenograft Mouse Model

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