Effects Of A Standardized Aqueous Extract Of Polygonum Minus On Stress-Induced Behavior And Neurobiological Changes In Mice

Effects Of A Standardized Aqueous Extract Of Polygonum Minus On Stress-Induced Behavior And Neurobiological Changes In Mice

Stress is a reaction of the body against various physical or emotional events. Stress can induce the depression, anxiety and as well as impairs cognition. Chronic ultra-mild stress (CUMS) model is used to mimic the anxiety and depressive like disorders in animals. There is a need for new medicinal a...

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Main Author: Bashir, Muhammad Irfan
Format: Thesis
Language:English
Published: 2022
Subjects:
RS1-441 Pharmacy and materia medica
Online Access:http://eprints.usm.my/59718/1/24%20Pages%20from%20MUHAMMAD%20IRFAN%20BASHIR%20-%20TESIS.pdf
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spelling my-usm-ep.597182023-12-20T02:31:08Z Effects Of A Standardized Aqueous Extract Of Polygonum Minus On Stress-Induced Behavior And Neurobiological Changes In Mice 2022-09 Bashir, Muhammad Irfan RS1-441 Pharmacy and materia medica Stress is a reaction of the body against various physical or emotional events. Stress can induce the depression, anxiety and as well as impairs cognition. Chronic ultra-mild stress (CUMS) model is used to mimic the anxiety and depressive like disorders in animals. There is a need for new medicinal agents to treat the anxiety and mood disorders more adequately. A standardized aqueous extract of Polygonum minus was used in this research, in which quercetin-3- glucuronide and quercitrin (quercetin 3-rhamnoside) were the major constituents. The main aim of this study was to evaluate the effects of P. minus aqueous extract on chronic ultra-mild stress (CUMS) induced behavioral and neurobiological change in mice model. Treatment was given for 8 weeks in which the mice were subjected to chronic ultra-mild stress for 6 weeks. The behavior of subjects was investigated through the sucrose preference test (SPT), forced swimming tests (FST), open field test (OFT), food consumption and food preference tests. Spatial memory was examined through the Barnes maze assay. Furthermore, levels of serum corticosterone, and levels of the following from the brain tissue: brain derived neurotrophic factor (BDNF), serotonin (5-HT), norepinephrine (NE), monoamine oxidase-A (MAO-A) enzyme, Kruppel-like factor 11(KLF11) and sirtuin (SIRT1) were measured. 2022-09 Thesis http://eprints.usm.my/59718/ http://eprints.usm.my/59718/1/24%20Pages%20from%20MUHAMMAD%20IRFAN%20BASHIR%20-%20TESIS.pdf application/pdf en public phd doctoral Perpustakaan Hamzah Sendut Pusat Pengajian Sains Farmasi
institution Universiti Sains Malaysia
collection USM Institutional Repository
language English
topic RS1-441 Pharmacy and materia medica
spellingShingle RS1-441 Pharmacy and materia medica
Bashir, Muhammad Irfan
Effects Of A Standardized Aqueous Extract Of Polygonum Minus On Stress-Induced Behavior And Neurobiological Changes In Mice
description Stress is a reaction of the body against various physical or emotional events. Stress can induce the depression, anxiety and as well as impairs cognition. Chronic ultra-mild stress (CUMS) model is used to mimic the anxiety and depressive like disorders in animals. There is a need for new medicinal agents to treat the anxiety and mood disorders more adequately. A standardized aqueous extract of Polygonum minus was used in this research, in which quercetin-3- glucuronide and quercitrin (quercetin 3-rhamnoside) were the major constituents. The main aim of this study was to evaluate the effects of P. minus aqueous extract on chronic ultra-mild stress (CUMS) induced behavioral and neurobiological change in mice model. Treatment was given for 8 weeks in which the mice were subjected to chronic ultra-mild stress for 6 weeks. The behavior of subjects was investigated through the sucrose preference test (SPT), forced swimming tests (FST), open field test (OFT), food consumption and food preference tests. Spatial memory was examined through the Barnes maze assay. Furthermore, levels of serum corticosterone, and levels of the following from the brain tissue: brain derived neurotrophic factor (BDNF), serotonin (5-HT), norepinephrine (NE), monoamine oxidase-A (MAO-A) enzyme, Kruppel-like factor 11(KLF11) and sirtuin (SIRT1) were measured.
format Thesis
qualification_name Doctor of Philosophy (PhD.)
qualification_level Doctorate
author Bashir, Muhammad Irfan
author_facet Bashir, Muhammad Irfan
author_sort Bashir, Muhammad Irfan
title Effects Of A Standardized Aqueous Extract Of Polygonum Minus On Stress-Induced Behavior And Neurobiological Changes In Mice
title_short Effects Of A Standardized Aqueous Extract Of Polygonum Minus On Stress-Induced Behavior And Neurobiological Changes In Mice
title_full Effects Of A Standardized Aqueous Extract Of Polygonum Minus On Stress-Induced Behavior And Neurobiological Changes In Mice
title_fullStr Effects Of A Standardized Aqueous Extract Of Polygonum Minus On Stress-Induced Behavior And Neurobiological Changes In Mice
title_full_unstemmed Effects Of A Standardized Aqueous Extract Of Polygonum Minus On Stress-Induced Behavior And Neurobiological Changes In Mice
title_sort effects of a standardized aqueous extract of polygonum minus on stress-induced behavior and neurobiological changes in mice
granting_institution Perpustakaan Hamzah Sendut
granting_department Pusat Pengajian Sains Farmasi
publishDate 2022
url http://eprints.usm.my/59718/1/24%20Pages%20from%20MUHAMMAD%20IRFAN%20BASHIR%20-%20TESIS.pdf
_version_ 1794024042654597120

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