Design, Synthesis, Biological Evaluation, And Molecular Docking Studies Of Ortho-Carboxamido Stilbenes As Anti-Diabetic And Anti-Proliferative Agents

Design, Synthesis, Biological Evaluation, And Molecular Docking Studies Of Ortho-Carboxamido Stilbenes As Anti-Diabetic And Anti-Proliferative Agents

A total of eleven ortho-carboxamido stilbenes (50a-50k) in 63-83 % yield have been synthesized using our modified Heck coupling method, and characterized using FT-IR, NMR, and HRMS. The research started with the Wittig reaction of 3,5-dimethoxybenzaldehyde (45) and methyltriphenylphosphonium iodide...

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Main Author: Mohamad, Norhadi
Format: Thesis
Language:English
Published: 2022
Subjects:
QD1-999 Chemistry
Online Access:http://eprints.usm.my/59726/1/Pages%20from%20NORHADI%20BIN%20MOHAMAD%20-%20TESIS%20cut.pdf
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spelling my-usm-ep.597262024-01-02T03:28:42Z Design, Synthesis, Biological Evaluation, And Molecular Docking Studies Of Ortho-Carboxamido Stilbenes As Anti-Diabetic And Anti-Proliferative Agents 2022-09 Mohamad, Norhadi QD1-999 Chemistry A total of eleven ortho-carboxamido stilbenes (50a-50k) in 63-83 % yield have been synthesized using our modified Heck coupling method, and characterized using FT-IR, NMR, and HRMS. The research started with the Wittig reaction of 3,5-dimethoxybenzaldehyde (45) and methyltriphenylphosphonium iodide to form 3,5-dimethoxystyrene (46) followed by the Heck reaction with amide derivatives (49) under basic conditions to provide the corresponding (E)-stilbene derivatives (50a-50k). Five ortho-carboxamido stilbenes (50a-50e) were subjected to anti-diabetic studies on α-amylase and α-glucosidase enzymes. 2022-09 Thesis http://eprints.usm.my/59726/ http://eprints.usm.my/59726/1/Pages%20from%20NORHADI%20BIN%20MOHAMAD%20-%20TESIS%20cut.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Kimia (School of Chemical Sciences)
institution Universiti Sains Malaysia
collection USM Institutional Repository
language English
topic QD1-999 Chemistry
spellingShingle QD1-999 Chemistry
Mohamad, Norhadi
Design, Synthesis, Biological Evaluation, And Molecular Docking Studies Of Ortho-Carboxamido Stilbenes As Anti-Diabetic And Anti-Proliferative Agents
description A total of eleven ortho-carboxamido stilbenes (50a-50k) in 63-83 % yield have been synthesized using our modified Heck coupling method, and characterized using FT-IR, NMR, and HRMS. The research started with the Wittig reaction of 3,5-dimethoxybenzaldehyde (45) and methyltriphenylphosphonium iodide to form 3,5-dimethoxystyrene (46) followed by the Heck reaction with amide derivatives (49) under basic conditions to provide the corresponding (E)-stilbene derivatives (50a-50k). Five ortho-carboxamido stilbenes (50a-50e) were subjected to anti-diabetic studies on α-amylase and α-glucosidase enzymes.
format Thesis
qualification_level Master's degree
author Mohamad, Norhadi
author_facet Mohamad, Norhadi
author_sort Mohamad, Norhadi
title Design, Synthesis, Biological Evaluation, And Molecular Docking Studies Of Ortho-Carboxamido Stilbenes As Anti-Diabetic And Anti-Proliferative Agents
title_short Design, Synthesis, Biological Evaluation, And Molecular Docking Studies Of Ortho-Carboxamido Stilbenes As Anti-Diabetic And Anti-Proliferative Agents
title_full Design, Synthesis, Biological Evaluation, And Molecular Docking Studies Of Ortho-Carboxamido Stilbenes As Anti-Diabetic And Anti-Proliferative Agents
title_fullStr Design, Synthesis, Biological Evaluation, And Molecular Docking Studies Of Ortho-Carboxamido Stilbenes As Anti-Diabetic And Anti-Proliferative Agents
title_full_unstemmed Design, Synthesis, Biological Evaluation, And Molecular Docking Studies Of Ortho-Carboxamido Stilbenes As Anti-Diabetic And Anti-Proliferative Agents
title_sort design, synthesis, biological evaluation, and molecular docking studies of ortho-carboxamido stilbenes as anti-diabetic and anti-proliferative agents
granting_institution Universiti Sains Malaysia
granting_department Pusat Pengajian Sains Kimia (School of Chemical Sciences)
publishDate 2022
url http://eprints.usm.my/59726/1/Pages%20from%20NORHADI%20BIN%20MOHAMAD%20-%20TESIS%20cut.pdf
_version_ 1794024044126797824

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