Removal, Pre-concentration And Determination Of Selected Pharmaceuticals From Environmental Water Samples

Pharmaceuticals are emerging contaminants that have been widely used in various applications, including human and veterinary medicine, as well as agricultural activities. The pharmaceutical analysis relies on accurate quantification of target pharmaceuticals from a complex matrix, yet this remains a...

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Main Author:	Mohammad, Rania Edrees Adam
Format:	Thesis
Language:	English
Published:	2022
Subjects:	QD1-999 Chemistry
Online Access:	http://eprints.usm.my/59878/1/RANIA%20EDREES%20ADAM%20MOHAMMAD%20-%20TESIS24.pdf
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spelling	my-usm-ep.598782024-02-14T07:17:47Z Removal, Pre-concentration And Determination Of Selected Pharmaceuticals From Environmental Water Samples 2022-06 Mohammad, Rania Edrees Adam QD1-999 Chemistry Pharmaceuticals are emerging contaminants that have been widely used in various applications, including human and veterinary medicine, as well as agricultural activities. The pharmaceutical analysis relies on accurate quantification of target pharmaceuticals from a complex matrix, yet this remains a difficult task due to their low concentrations. Therefore, this research demonstrated the use of different sample preparation methods for the determination of selected pharmaceuticals in water samples. A microextraction technique based on vortex-assisted liquid-liquid microextraction with back extraction (VALLME-BE) was developed for the determination of nonsteroidal anti-inflammatory drugs (NSAIDs) namely, ketoprofen, naproxen, diclofenac, and ibuprofen. The procedure was carried out by adding 225 μL of butyl acetate into 10 mL spiked working standard for VALLME procedure, followed by the back-extraction into sodium hydroxide prior to high performance liquid chromatography-UV-Vis (HPLC-UV-Vis) analysis. Under optimum conditions, the proposed technique provided good linearity (R2 ≥ 0.9809), repeatability (%RSD; 3.4 – 16.1), and excellent the limits of detection (LOD) and limit of quantification (LOQ) values (ketoprofen (0.134 and 0.407 μg L-1), naproxen (0.015 and 0.047 μg L-1), diclofenac (0.03 and 0.091 μg L-1) and ibuprofen (0.05 and 0.152 μg L-1) were obtained. On the other hand, graphene oxide (GO), graphene oxide magnetite (GO@Fe3O4), and graphene oxide magnetite-deep eutectic solvent ferrofluid (GO@Fe3O4-DES FF) adsorbents were successfully synthesized and characterized 2022-06 Thesis http://eprints.usm.my/59878/ http://eprints.usm.my/59878/1/RANIA%20EDREES%20ADAM%20MOHAMMAD%20-%20TESIS24.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Pusat Pengajian Sains Kimia
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	QD1-999 Chemistry
spellingShingle	QD1-999 Chemistry Mohammad, Rania Edrees Adam Removal, Pre-concentration And Determination Of Selected Pharmaceuticals From Environmental Water Samples
description	Pharmaceuticals are emerging contaminants that have been widely used in various applications, including human and veterinary medicine, as well as agricultural activities. The pharmaceutical analysis relies on accurate quantification of target pharmaceuticals from a complex matrix, yet this remains a difficult task due to their low concentrations. Therefore, this research demonstrated the use of different sample preparation methods for the determination of selected pharmaceuticals in water samples. A microextraction technique based on vortex-assisted liquid-liquid microextraction with back extraction (VALLME-BE) was developed for the determination of nonsteroidal anti-inflammatory drugs (NSAIDs) namely, ketoprofen, naproxen, diclofenac, and ibuprofen. The procedure was carried out by adding 225 μL of butyl acetate into 10 mL spiked working standard for VALLME procedure, followed by the back-extraction into sodium hydroxide prior to high performance liquid chromatography-UV-Vis (HPLC-UV-Vis) analysis. Under optimum conditions, the proposed technique provided good linearity (R2 ≥ 0.9809), repeatability (%RSD; 3.4 – 16.1), and excellent the limits of detection (LOD) and limit of quantification (LOQ) values (ketoprofen (0.134 and 0.407 μg L-1), naproxen (0.015 and 0.047 μg L-1), diclofenac (0.03 and 0.091 μg L-1) and ibuprofen (0.05 and 0.152 μg L-1) were obtained. On the other hand, graphene oxide (GO), graphene oxide magnetite (GO@Fe3O4), and graphene oxide magnetite-deep eutectic solvent ferrofluid (GO@Fe3O4-DES FF) adsorbents were successfully synthesized and characterized
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Mohammad, Rania Edrees Adam
author_facet	Mohammad, Rania Edrees Adam
author_sort	Mohammad, Rania Edrees Adam
title	Removal, Pre-concentration And Determination Of Selected Pharmaceuticals From Environmental Water Samples
title_short	Removal, Pre-concentration And Determination Of Selected Pharmaceuticals From Environmental Water Samples
title_full	Removal, Pre-concentration And Determination Of Selected Pharmaceuticals From Environmental Water Samples
title_fullStr	Removal, Pre-concentration And Determination Of Selected Pharmaceuticals From Environmental Water Samples
title_full_unstemmed	Removal, Pre-concentration And Determination Of Selected Pharmaceuticals From Environmental Water Samples
title_sort	removal, pre-concentration and determination of selected pharmaceuticals from environmental water samples
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Kimia
publishDate	2022
url	http://eprints.usm.my/59878/1/RANIA%20EDREES%20ADAM%20MOHAMMAD%20-%20TESIS24.pdf
_version_	1794024067246850048

Removal, Pre-concentration And Determination Of Selected Pharmaceuticals From Environmental Water Samples

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