Behavioural And Hippocampal Neuroplasticity Effects Of A Bioactive Fraction From Clitoria Ternatea Linn. Root Extract In A Rat Model Of Chronic Cerebral Hypoperfusion

Pharmacological therapy is highly recommended for reducing the severity of the behavioural and psychiatric syndromes of dementia, as well as for effectively reversing cognitive decline in symptomatic dementia patients. Scientific evidence on cognition-oriented approaches for treating cognitive impai...

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Main Author:	Ahad, Mohamad Anuar
Format:	Thesis
Language:	English
Published:	2022
Subjects:	RM300-666 Drugs and their actions
Online Access:	http://eprints.usm.my/60048/1/24%20Pages%20from%20MOHAMAD%20ANUAR%20BIN%20AHAD.pdf
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id	my-usm-ep.60048
record_format	uketd_dc
spelling	my-usm-ep.600482024-03-05T01:56:44Z Behavioural And Hippocampal Neuroplasticity Effects Of A Bioactive Fraction From Clitoria Ternatea Linn. Root Extract In A Rat Model Of Chronic Cerebral Hypoperfusion 2022-11 Ahad, Mohamad Anuar RM300-666 Drugs and their actions Pharmacological therapy is highly recommended for reducing the severity of the behavioural and psychiatric syndromes of dementia, as well as for effectively reversing cognitive decline in symptomatic dementia patients. Scientific evidence on cognition-oriented approaches for treating cognitive impairment using natural-based products is well discovered. Therefore, the thesis investigates the effects of bioactive fraction from Clitoria ternatea (CT) root extract in the behavioural and hippocampal neuroplasticity in chronic cerebral hypoperfusion (CCH) rats model. The bioassay-guided fractionation approach was carried out to produce the CT root bioactive fraction. To begin with, CT root powder was extracted using sequential extraction of solvent varying polarity. Then, the extracts were screened for their bioactivity using in vitro and in vivo studies. The CT root chloroform extract was further subjected to fractionation and isolation compound(s) using column chromatography to produce the bioactive fraction and active compound(s). The amount of clitorienolactone A (CLA) in the CT root bioactive fraction (255 mg/g) and active extract (150 mg/g) was quantified using high-performance liquid chromatography and diode array detection analysis for quality control purposes. 2022-11 Thesis http://eprints.usm.my/60048/ http://eprints.usm.my/60048/1/24%20Pages%20from%20MOHAMAD%20ANUAR%20BIN%20AHAD.pdf application/pdf en public phd doctoral Perpustakaan Hamzah Sendut Pusat Penyelidikan Dadah Dan Ubat-Ubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RM300-666 Drugs and their actions
spellingShingle	RM300-666 Drugs and their actions Ahad, Mohamad Anuar Behavioural And Hippocampal Neuroplasticity Effects Of A Bioactive Fraction From Clitoria Ternatea Linn. Root Extract In A Rat Model Of Chronic Cerebral Hypoperfusion
description	Pharmacological therapy is highly recommended for reducing the severity of the behavioural and psychiatric syndromes of dementia, as well as for effectively reversing cognitive decline in symptomatic dementia patients. Scientific evidence on cognition-oriented approaches for treating cognitive impairment using natural-based products is well discovered. Therefore, the thesis investigates the effects of bioactive fraction from Clitoria ternatea (CT) root extract in the behavioural and hippocampal neuroplasticity in chronic cerebral hypoperfusion (CCH) rats model. The bioassay-guided fractionation approach was carried out to produce the CT root bioactive fraction. To begin with, CT root powder was extracted using sequential extraction of solvent varying polarity. Then, the extracts were screened for their bioactivity using in vitro and in vivo studies. The CT root chloroform extract was further subjected to fractionation and isolation compound(s) using column chromatography to produce the bioactive fraction and active compound(s). The amount of clitorienolactone A (CLA) in the CT root bioactive fraction (255 mg/g) and active extract (150 mg/g) was quantified using high-performance liquid chromatography and diode array detection analysis for quality control purposes.
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Ahad, Mohamad Anuar
author_facet	Ahad, Mohamad Anuar
author_sort	Ahad, Mohamad Anuar
title	Behavioural And Hippocampal Neuroplasticity Effects Of A Bioactive Fraction From Clitoria Ternatea Linn. Root Extract In A Rat Model Of Chronic Cerebral Hypoperfusion
title_short	Behavioural And Hippocampal Neuroplasticity Effects Of A Bioactive Fraction From Clitoria Ternatea Linn. Root Extract In A Rat Model Of Chronic Cerebral Hypoperfusion
title_full	Behavioural And Hippocampal Neuroplasticity Effects Of A Bioactive Fraction From Clitoria Ternatea Linn. Root Extract In A Rat Model Of Chronic Cerebral Hypoperfusion
title_fullStr	Behavioural And Hippocampal Neuroplasticity Effects Of A Bioactive Fraction From Clitoria Ternatea Linn. Root Extract In A Rat Model Of Chronic Cerebral Hypoperfusion
title_full_unstemmed	Behavioural And Hippocampal Neuroplasticity Effects Of A Bioactive Fraction From Clitoria Ternatea Linn. Root Extract In A Rat Model Of Chronic Cerebral Hypoperfusion
title_sort	behavioural and hippocampal neuroplasticity effects of a bioactive fraction from clitoria ternatea linn. root extract in a rat model of chronic cerebral hypoperfusion
granting_institution	Perpustakaan Hamzah Sendut
granting_department	Pusat Penyelidikan Dadah Dan Ubat-Ubatan
publishDate	2022
url	http://eprints.usm.my/60048/1/24%20Pages%20from%20MOHAMAD%20ANUAR%20BIN%20AHAD.pdf
_version_	1794024082660917248

Behavioural And Hippocampal Neuroplasticity Effects Of A Bioactive Fraction From Clitoria Ternatea Linn. Root Extract In A Rat Model Of Chronic Cerebral Hypoperfusion

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